{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:07:20Z","timestamp":1771034840120,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.ejphar.2004.09.034","type":"journal-article","created":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T15:18:48Z","timestamp":1097767128000},"page":"191-201","source":"Crossref","is-referenced-by-count":27,"title":["Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens"],"prefix":"10.1016","volume":"503","author":[{"given":"Afonso","family":"Caricati-Neto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos Abech","family":"D'angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydee","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neide","family":"Hyppolito Jurkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"G. Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron","family":"Jurkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2004.09.034_bib1","first-page":"151","article-title":"Galantamine induces neurotransmitter release likely by blocking SK channels: a new mechanism of action for anti-Alzheimer's drugs","volume":"24","author":"Al\u00e9s","year":"2002","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF00973747","article-title":"Studies on new, centrally active and reversible acetylcholinesterase inhibitors","volume":"15","author":"Arnal","year":"1990","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2004.09.034_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00374966","article-title":"Small conductance Ca2+-activated K+ channels in bovine chromaffin cells","volume":"423","author":"Artalejo","year":"1993","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1748-1716.1986.tb07790.x","article-title":"The changing face of autonomic neurotransmission","volume":"126","author":"Burnstock","year":"1986","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2004.09.034_bib5","first-page":"7","article-title":"The fifth Heymans memorial lecture co-transmission","volume":"304","author":"Burnstock","year":"1990","journal-title":"Arch. Int. Pharmacodyn."},{"key":"10.1016\/j.ejphar.2004.09.034_bib6","first-page":"365","article-title":"Noradrenaline and ATP: cotransmitters and neuromodulators","volume":"46","author":"Burnstock","year":"1995","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0014-2999(92)90146-U","article-title":"Increased density of \u03b1-adrenoceptors in vas deferens of spontaneously hypertensive rats (SHR), indicated by functional and receptor binding studies","volume":"218","author":"Caricati-Neto","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib8","first-page":"95","article-title":"Prejunctional nicotinic receptors involved in release of noradrenaline and ATP from the prostatic portion of the rat vas deferens","volume":"255","author":"Carneiro","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2004.09.034_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1476-5381.1992.tb14241.x","article-title":"Low dihydropyridine receptor density in vasa deferentia of castrated rats","volume":"105","author":"Castillo","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0006-3223(00)01101-X","article-title":"Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease","volume":"49","author":"Coyle","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2004.09.034_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2999(95)00495-5","article-title":"Prejunctional actions of K+ channels blockers in rat vas deferens","volume":"287","author":"Docherty","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00171334","article-title":"Neural ATP release and its \u03b12-adrenoceptor-mediated modulation in guinea-pig vas deferens","volume":"348","author":"Driessen","year":"1993","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1749-6632.1991.tb00232.x","article-title":"Pharmacologic and clinicopharmacologic properties of SDZ ENA 713, a centrally selective acetylcholinesterase inhibitor","volume":"640","author":"Enz","year":"1991","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2004.09.034_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1212\/WNL.57.4.613","article-title":"A 24-week randomized, double blind study of donepezil in moderate to severe Alzheimer's disease","volume":"57","author":"Feldman","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2004.09.034_bib16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s007020200089","article-title":"Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit","volume":"109","author":"Giacobini","year":"2002","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.09.034_bib17","first-page":"81","article-title":"Differences in the manner of autonomic innervation of the muscle layers of the guinea-pig ductus deferens","volume":"112","author":"Gosling","year":"1972","journal-title":"J. Anat."},{"key":"10.1016\/j.ejphar.2004.09.034_bib18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00424-002-0986-7","article-title":"Voltage-gated potassium currents in rat vas deferens smooth muscle cells","volume":"446","author":"Harhun","year":"2003","journal-title":"Eur. J. Phys."},{"key":"10.1016\/j.ejphar.2004.09.034_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1476-5381.1976.tb07439.x","article-title":"Dual effect of alpha-adrenoceptor antagonists in rat isolated vas deferens","volume":"56","author":"Jurkiewicz","year":"1976","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000136005","article-title":"Relative responsiveness (\u03c1): of pharmacological receptor systems in the rat vas deferens","volume":"2","author":"Jurkiewicz","year":"1969","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2004.09.034_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0306-3623(76)90042-2","article-title":"Relative responsiveness (\u03c1): a critical analysis of a new method in receptor differentiation","volume":"7","author":"Jurkiewicz","year":"1976","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib22","first-page":"133","article-title":"Action of nicotine on sympathetic nerve terminals","volume":"213","author":"Kirpekar","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2004.09.034_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-4328(00)00214-X","article-title":"Allosterically potentiating ligands of nicotinic receptors a treatment strategy for Alzheimer's disease","volume":"113","author":"Maelicke","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2004.09.034_bib24","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/0306-3623(94)90366-2","article-title":"Pre- and postjunctional muscarinic receptor subtypes in the vas deferens of rat","volume":"25","author":"Miranda","year":"1994","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0306-3623(94)00185-P","article-title":"Muscarinic receptor subtypes in the bisected vas deferens of the rat","volume":"26","author":"Miranda","year":"1995","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib26","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/0306-3623(93)90377-A","article-title":"Comparative effects of the anticholinesterase drug galantamine on the mechanical activity of isolated rat jejunum and ileum","volume":"24","author":"Mutafova-Yambolieva","year":"1993","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib27","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1358\/mf.2000.22.8.701373","article-title":"Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrilcholonesterase in vitro","volume":"22","author":"Ogura","year":"2000","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/00001756-199403000-00002","article-title":"Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease","volume":"5","author":"Perry","year":"1994","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2004.09.034_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF03542977","article-title":"Cholinesterases in Alzheimer's disease and cholinesterase inhibitors in Alzheimer's therapy","volume":"49","author":"Rakonczay","year":"1998","journal-title":"Acta Biol. Hung."},{"key":"10.1016\/j.ejphar.2004.09.034_bib30","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1083\/jcb.41.2.462","article-title":"A cholinergic component in the innervation of the longitudinal smooth muscle of the guinea-pig vas deferens: the fine structural localization of acetylcholinesterase","volume":"41","author":"Robinson","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-3940(86)90558-6","article-title":"Assimetric distribution of purinergic and adrenergic neurotransmission cooperates in the motor activity along the rat vas deferens","volume":"71","author":"Rodhe","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2004.09.034_bib32","first-page":"150","article-title":"Ca++-activated K+ currents in neurones: types, physiological roles and modulation","volume":"19","author":"Sah","year":"1996","journal-title":"TINS"},{"key":"10.1016\/j.ejphar.2004.09.034_bib33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1124\/mol.61.5.1222","article-title":"The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system","volume":"61","author":"Santos","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib34","series-title":"Smooth Muscle","first-page":"367","article-title":"Smooth muscle of vas deferens and other organs in the male reproductive tract","author":"Sjostrand","year":"1981"},{"key":"10.1016\/j.ejphar.2004.09.034_bib35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.2042-7158.1988.tb05172.x","article-title":"Some pharmacological properties of the circular smooth muscle layer of the rat vas deferens","volume":"40","author":"Souza Brito","year":"1988","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib36","first-page":"93","article-title":"Noradrenaline-ATP corelease and cotransmission following activation of nicotinic receptors at postganglionic sympathetic axons","volume":"34","author":"Starke","year":"1991","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.ejphar.2004.09.034_bib37","first-page":"145","article-title":"Use of THA in treatment of Alzheimer's like dementia: pilot study in twelve patients","volume":"16","author":"Summers","year":"1981","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2004.09.034_bib38","first-page":"481","article-title":"Huperzine A (shuangyiping): a promising drug for Alzheimer's disease","volume":"17","author":"Tang","year":"1996","journal-title":"Zhongguo Yao Xuebao"},{"key":"10.1016\/j.ejphar.2004.09.034_bib39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1476-5381.1991.tb12151.x","article-title":"Prejunctional nicotinic receptors involved in facilitation of stimulation-evoked noradrenaline release from the vas deferens of the guinea-pig","volume":"102","author":"Todorov","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.09.034_bib40","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0024-3205(94)00240-1","article-title":"Evidence for participation of nitric oxide in excitatory neurotransmitter in rat vas deferens","volume":"55","author":"Vladimirova","year":"1994","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2004.09.034_bib41","first-page":"424","article-title":"Effect of castration on the smooth muscle cells of the internal sex organs of the rat: influence of the smooth muscle on the sympathetic neurons innervating the vas deferens, seminal vesicle and coagulating gland","volume":"193","author":"Wakade","year":"1975","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299904010957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299904010957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T15:27:20Z","timestamp":1682782040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299904010957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":41,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0014299904010957"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2004.09.034","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}