{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:06:36Z","timestamp":1789967196486,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.ejphar.2005.01.026","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T17:49:07Z","timestamp":1109353747000},"page":"187-195","source":"Crossref","is-referenced-by-count":16,"title":["Activation of apical CFTR and basolateral Ca2+-activated K+ channels by tetramethylpyrazine in Caco-2 cell line"],"prefix":"10.1016","volume":"510","author":[{"given":"Jin Xia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi Kenneth","family":"Rowlands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hau Yan Connie","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Ling","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiu Wa","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao Chang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.01.026_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-5793(99)00891-1","article-title":"Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea","volume":"455","author":"Agnel","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2005.01.026_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00232-003-0621-3","article-title":"Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line","volume":"196","author":"Bernard","year":"2003","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib3","first-page":"747","article-title":"Observation on curative effect of acute ischemic cerebrovascular disease treated with different dosage of ligustrazine","volume":"20","author":"Cai","year":"2000","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.ejphar.2005.01.026_bib4","first-page":"377","article-title":"Cystic fibrosis transmembrane regulator mRNA expression relative to ion-nutrient transport in spontaneously differentiating human intestinal Caco-2 epithelial cells","volume":"118","author":"Chang","year":"1991","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2005.01.026_bib5","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0092-8674(91)90446-6","article-title":"Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel","volume":"66","author":"Cheng","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2005.01.026_bib6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1006\/bbrc.1996.1861","article-title":"Deregulated expression and function of CFTR and Cl\u2212 secretion after activation of the Ras and Src\/PyMT pathways in Caco-2 cells","volume":"229","author":"Davenport","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2005.01.026_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1085\/jgp.113.5.743","article-title":"Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells","volume":"113","author":"Devor","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2170\/jjphysiol.50.215","article-title":"Activation of transepithelial ion transport by secretin in human intestinal Caco-2 cells","volume":"50","author":"Fukuda","year":"2000","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib9","doi-asserted-by":"crossref","first-page":"C410","DOI":"10.1152\/ajpcell.1985.248.5.C410","article-title":"Epithelial properties of human colonic carcinoma cell line Caco-2: effect of secretagogues","volume":"248","author":"Grasset","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/347382a0","article-title":"Expression and characterization of the cystic fibrosis transmembrane conductance regulator","volume":"347","author":"Gregory","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2005.01.026_bib11","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1152\/physrev.1999.79.1.S167","article-title":"Biosynthesis and degradation of CFTR","volume":"79","author":"Kopito","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2005.01.026_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","article-title":"Electrolyte transport in the mammalian colon: mechanisms and implications for disease","volume":"82","author":"Kunzelmann","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2005.01.026_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00005344-199001000-00025","article-title":"Inhibition of vasoconstriction by tetramethylpyrazine: does it act by blocking the voltage-dependent Ca2+ channel?","volume":"15","author":"Kwan","year":"1990","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0049-3848(01)00343-7","article-title":"Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine \u2018Chuanxiong\u2019, on platelet thrombus formation under high shear rates","volume":"104","author":"Li","year":"2001","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ejphar.2005.01.026_bib15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.2042-7158.1993.tb05636.x","article-title":"The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues","volume":"45","author":"Lin","year":"1993","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib16","first-page":"261","article-title":"Clinical study on ligustrazine in treating myocardial ischemia and reperfusion injury","volume":"17","author":"Lin","year":"1997","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.ejphar.2005.01.026_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0049-3848(94)90139-2","article-title":"Antiplatelet activity of tetramethylpyrazine","volume":"75","author":"Liu","year":"1994","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ejphar.2005.01.026_bib18","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI0216112","article-title":"Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion","volume":"110","author":"Ma","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.01.026_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1469-7793.1998.237bz.x","article-title":"Importance of basolateral K+ conductance in maintaining Cl\u2212 secretion in murine nasal and colonic epithelia","volume":"510","author":"MacVinish","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib20","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1007\/s004240100659","article-title":"EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes","volume":"443","author":"MacVinish","year":"2001","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ejphar.2005.01.026_bib21","first-page":"G1274","article-title":"Cholinergic ion secretion in human colon requires coactivation by cAMP","volume":"275","author":"Mall","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib22","first-page":"L1208","article-title":"Calcium-stimulated Cl\u2212 secretion in Calu-3 human airway cells requires CFTR","volume":"273","author":"Moon","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib23","doi-asserted-by":"crossref","first-page":"C484","DOI":"10.1152\/ajpcell.1998.275.2.C484","article-title":"Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells","volume":"275","author":"Merlin","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1074\/jbc.M207199200","article-title":"Ca2+ activates cystic fibrosis transmembrane conductance regulator- and Cl\u2212-dependent HCO3\u2212 transport in pancreatic duct cells","volume":"278","author":"Namkung","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.01.026_bib25","doi-asserted-by":"crossref","first-page":"C161","DOI":"10.1152\/ajpcell.1993.264.1.C161","article-title":"Inhibition of cAMP- and Ca2+-dependent Cl\u2212 secretion by phorbol esters: inhibition of basolateral K+ channels","volume":"264","author":"Reenstra","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.bjp.0704028","article-title":"Regulation of prostacyclin and prostaglandin E2 receptor mediated responses in adult rat dorsal root ganglion cells, in vitro","volume":"133","author":"Rowlands","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1165\/rcmb.2003-0183OC","article-title":"Apical and basolateral ATP-induced anion secretion in polarized human airway epithelia","volume":"30","author":"Son","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/gast.2001.20917","article-title":"Oxidants potentiate Ca2+- and cAMP-stimulated Cl\u2212 secretion in intestinal epithelial T84 cells","volume":"120","author":"Sugi","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2005.01.026_bib29","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1093\/cvr\/27.11.1891","article-title":"Recent cardiovascular drugs from Chinese medicinal plants","volume":"27","author":"Sutter","year":"1993","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2005.01.026_bib30","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1096\/fj.03-1248fje","article-title":"A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways","volume":"18","author":"Thiagarajah","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2005.01.026_bib31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/j.gastro.2003.11.005","article-title":"Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor","volume":"126","author":"Thiagarajah","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2005.01.026_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1172\/JCI11869","article-title":"Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis","volume":"108","author":"Usui","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.01.026_bib33","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.1074\/jbc.M111917200","article-title":"Stimulation of Cl\u2212 secretion via membrane-restricted Ca2+ signaling mediated by P2Y receptors in polarized epithelia","volume":"277","author":"Wong","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.01.026_bib34","first-page":"478","article-title":"Clinical study of naoxin sutong in the treatment of acute cerebral infarction","volume":"14","author":"Zhang","year":"1994","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.ejphar.2005.01.026_bib35","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.3748\/wjg.v9.i11.2505","article-title":"Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion","volume":"9","author":"Zhao","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib36","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1006\/cbir.2002.0960","article-title":"Bak Foong Pills stimulate anion secretion across normal and cystic fibrosis pancreatic duct epithelia","volume":"26","author":"Zhu","year":"2002","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejphar.2005.01.026_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2170\/jjphysiol.52.129","article-title":"Cellular signaling mechanisms underlying pharmacological action of Bak Foong Pills on gastrointestinal secretion","volume":"52","author":"Zhu","year":"2002","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.01.026_bib38","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3748\/wjg.v10.i12.1763","article-title":"Differential Cl\u2212 and HCO3\u2212 mediated anion secretion by different colonic cell types in response to tetromethylpyrazine","volume":"10","author":"Zhu","year":"2004","journal-title":"World J. Gastroenterol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T15:04:04Z","timestamp":1548774244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299905000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0014299905000476"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.01.026","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}