{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:55:27Z","timestamp":1761742527642},"reference-count":45,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.ejphar.2005.01.038","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T23:18:26Z","timestamp":1111274306000},"page":"183-189","source":"Crossref","is-referenced-by-count":15,"title":["Morphine modulates inducible nitric oxide synthase expression and reduces pulmonary oedema induced by \u03b1-naphthylthiourea"],"prefix":"10.1016","volume":"511","author":[{"given":"Mustafa","family":"Comert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Yilmaz Sipahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Ustun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulden","family":"Isikdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Numanoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Barut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanife","family":"Altunkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yetkin","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruh","family":"Niyazi Ayoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tunc","family":"Hakan Sipahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishak","family":"Ozel Tekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Nur Banoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.01.038_bib1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/00000542-200106000-00018","article-title":"Analgesic and antiinflammatory effects of two novel K-opioid peptides","volume":"94","author":"Binder","year":"2001","journal-title":"Anesthesiology"},{"issue":"7528","key":"10.1016\/j.ejphar.2005.01.038_bib2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0140-6736(67)90565-X","article-title":"Severe systemic infections complicating mainline heroin addiction","volume":"2","author":"Briggs","year":"1967","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ejphar.2005.01.038_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0167-5273(97)00229-5","article-title":"Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response","volume":"62","author":"Brix-Christensen","year":"1997","journal-title":"Int. J. Cardiol."},{"issue":"6","key":"10.1016\/j.ejphar.2005.01.038_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/archinte.134.6.1001","article-title":"Immunologic dysfunction in heroin addicts","volume":"134","author":"Brown","year":"1974","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ejphar.2005.01.038_bib5","series-title":"Handbook of experimental pharmacology: opioids II","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/978-3-642-77540-6_15","article-title":"Opioids in immunologic processes","author":"Bryant","year":"1993"},{"issue":"2","key":"10.1016\/j.ejphar.2005.01.038_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0922-4106(94)90195-3","article-title":"Characterization of non-conventional opioid binding sites in rat and human lung","volume":"268","author":"Cabot","year":"1994","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2005.01.038_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(96)00363-9","article-title":"Quantitative autoradiography of peripheral opioid binding sites in rat lung","volume":"310","author":"Cabot","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2005.01.038_bib8","first-page":"321","article-title":"Morphine modulation of thioglycollate-elicited peritoneal inflammation in the goldfish, Carassius auratus","volume":"45","author":"Chadzinska","year":"1997","journal-title":"Arch. Immunol. Ther. Exp. (Warsz.)"},{"key":"10.1016\/j.ejphar.2005.01.038_bib9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3181\/00379727-181-42272","article-title":"Actions of opiate agonists, naloxone, and parben preservatives in the rat lung circulation","volume":"181","author":"Chang","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"11","key":"10.1016\/j.ejphar.2005.01.038_bib10","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0024-3205(99)00348-3","article-title":"Morphine reduces pulmonary inflammation in response to influenza infection","volume":"65","author":"Coussons-Read","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2005.01.038_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.1711060103","article-title":"Alpha-naphthylthiourea-induced pulmonary oedema in the rat: a topographical and electron microscopy study","volume":"106","author":"Cunningham","year":"1972","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejphar.2005.01.038_bib12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0891-5849(97)00280-3","article-title":"Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation","volume":"24","author":"Cuzzocrea","year":"1998","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2005.01.038_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.2042-7158.1985.tb05015.x","article-title":"Morphine inhibits the carrageenan-induced oedema and chemoluminescence of leukocytes stimulated by zymosan","volume":"37","author":"Gyires","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.01.038_bib14","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0006-2952(91)90255-4","article-title":"Protection of rats against the effects of \u03b1-naphthylthiourea (ANTU) by elevation of non-protein sulphydryl levels","volume":"42","author":"Hardwick","year":"1991","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2005.01.038_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0002-9343(50)90021-0","article-title":"Infections resulting from narcotic addiction; report of 102 cases","volume":"9","author":"Hussey","year":"1950","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2005.01.038_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0304-3959(90)90054-H","article-title":"Opiates suppress carrageenan-induced oedema and hyperthermia at doses that inhibit hyperalgesia","volume":"43","author":"Joris","year":"1990","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ejphar.2005.01.038_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0304-3959(90)90012-3","article-title":"Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats","volume":"41","author":"Kayser","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2005.01.038_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0079-6123(08)62796-X","article-title":"Paradoxical effects of low doses of naloxone in experimental models of inflammatory pain","volume":"77","author":"Kayser","year":"1988","journal-title":"Prog. Brain Res."},{"issue":"3","key":"10.1016\/j.ejphar.2005.01.038_bib19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(85)90365-6","article-title":"Opioid control of the function of primary afferent substance P fibres","volume":"114","author":"Lembeck","year":"1985","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2005.01.038_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-67-1-1","article-title":"The major medical complications of heroin addiction","volume":"67","author":"Louria","year":"1967","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2005.01.038_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/A:1010924320902","article-title":"Morphine-6\u03b2-glucuronide modulates the expression of inducible nitric oxide synthase","volume":"25","author":"Lysle","year":"2001","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2005.01.038_bib22","first-page":"502","article-title":"Endogenous opioids regulate the expression of inducible nitric oxide synthase by splenocytes","volume":"288","author":"Lysle","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.01.038_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0162-3109(99)00172-1","article-title":"Heroin modulates the expression of inducible nitric oxide synthase","volume":"46","author":"Lysle","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ejphar.2005.01.038_bib24","first-page":"1071","article-title":"Morphine-induced alterations of immune status: dose-dependency, compartment specificity and antagonism by naltrexone","volume":"265","author":"Lysle","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.01.038_bib25","first-page":"347","article-title":"Pulmonary edema induced by ANTU or by high or low oxygen concentrations in rat\u2014an electron microscopic study","volume":"53","author":"Meyrick","year":"1972","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2005.01.038_bib26","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2005.01.038_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0024-3205(95)00285-E","article-title":"Possible role of endogenous morphine and codeine on growth regulation of lung tissue","volume":"57","author":"Munjal","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2005.01.038_bib28","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1096\/fasebj.6.12.1381691","article-title":"Nitric oxide as a secretory product of mammalian cells","volume":"6","author":"Nathan","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2005.01.038_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.7326\/0003-4819-57-5-755","article-title":"Staphylococcal tricuspid endocarditis in heroin addicts","volume":"57","author":"Olsson","year":"1962","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2005.01.038_bib30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0090-6980(85)80009-5","article-title":"Effect of pulmonary oedema by alphanaphthylthiourea on synthesis of cyclooxygenase products in isolated rat lungs","volume":"30","author":"Pankhania","year":"1982","journal-title":"Prostaglandins"},{"key":"10.1016\/j.ejphar.2005.01.038_bib31","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/00000542-200105000-00027","article-title":"Differential behavioral effects of peripheral and systemic morphine and naloxone in a rat model of repeated acute inflammation","volume":"94","author":"Perrot","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2005.01.038_bib32","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI108492","article-title":"The relationship between right duct lymph flow and extravascular lung water in dogs given ANTU","volume":"58","author":"Pine","year":"1976","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.01.038_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0304-3959(94)00090-2","article-title":"Pharmacological evidence for the involvement of the endogenous opioid system in the response to local inflammation in the rat paw","volume":"60","author":"Planas","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2005.01.038_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0096-5588(20)31220-4","article-title":"The physiology and cytology of pulmonary edema and pleural effusion produced in rats by alphanaphthylthiourea (ANTU)","volume":"23","author":"Richter","year":"1952","journal-title":"J. Thorac. Surg."},{"key":"10.1016\/j.ejphar.2005.01.038_bib35","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/BC.2002.055","article-title":"Interaction of nitric oxide and peroxynitrite with low-density lipoprotein","volume":"383","author":"Rubbo","year":"2002","journal-title":"Biol. Chem."},{"issue":"2\u20133","key":"10.1016\/j.ejphar.2005.01.038_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0167-0115(96)00014-6","article-title":"Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat","volume":"63","author":"Sacerdote","year":"1996","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2005.01.038_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3959(98)00175-4","article-title":"Effects of kappa opioids in the inflamed rat colon","volume":"79","author":"Sengupta","year":"1999","journal-title":"Pain"},{"year":"1980","series-title":"Theory and practice of histotechnology","author":"Sheehan","key":"10.1016\/j.ejphar.2005.01.038_bib38"},{"key":"10.1016\/j.ejphar.2005.01.038_bib39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/phrs.1996.0052","article-title":"Acute effect of endothelin-1 on lung oedema induced by alpha-naphthylthiourea (ANTU)","volume":"33","author":"Sipahi","year":"1996","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2005.01.038_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0014-2999(96)00932-6","article-title":"An unexpected interaction between NG-nitro-l-arginine methyl ester and l-arginine in \u03b1-naphthylthiourea-induced pulmonary oedema in rats","volume":"321","author":"Sipahi","year":"1997","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2005.01.038_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/phrs.2001.0937","article-title":"Acute effects of pentobarbital, thiopental and urethane on lung oedema induced by alpha-naphthylthiourea (ANTU)","volume":"45","author":"Sipahi","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejphar.2005.01.038_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000139266","article-title":"Immunomodulatory effects of in vitro exposure to morphine and its metabolites","volume":"50","author":"Thomas","year":"1995","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2005.01.038_bib43","first-page":"1295","article-title":"The nitric oxide synthase inhibitor, l-NG-monomethyl arginine, reduces carrageenan-induced pleurisy in the rat","volume":"273","author":"Tracey","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.ejphar.2005.01.038_bib44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF02342227","article-title":"Effect of mu-opioids morphine and buprenorphine on the development of adjuvant arthritis in rats","volume":"45","author":"Walker","year":"1996","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.ejphar.2005.01.038_bib45","first-page":"499","article-title":"Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID","volume":"25","author":"Wilson","year":"1998","journal-title":"J. Rheumatol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990500141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990500141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T01:31:56Z","timestamp":1625621516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429990500141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":45,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S001429990500141X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.01.038","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}