{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:27:36Z","timestamp":1791941256667,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.ejphar.2005.03.023","type":"journal-article","created":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T13:32:18Z","timestamp":1114176738000},"page":"69-78","source":"Crossref","is-referenced-by-count":33,"title":["Effects of a selective bradykinin B1 receptor antagonist on increased plasma extravasation in streptozotocin-induced diabetic rats: Distinct vasculopathic profile of major key organs"],"prefix":"10.1016","volume":"514","author":[{"given":"Sibi R.","family":"Lawson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bichoy H.","family":"Gabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nantel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Battistini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sirois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.03.023_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.bjp.0705210","article-title":"Early upregulation of kinin B1 receptors in the retinal micro-vessels of the streptozotocin-diabetic rat","volume":"140","author":"Abdouh","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/mvre.1999.2209","article-title":"Endothelin and free radicals modulate microvascular responses in streptozotocin-induced diabetic rats","volume":"59","author":"Bassirat","year":"2000","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.ejphar.2005.03.023_bib3","first-page":"131","article-title":"Advanced glycosylated end products in tissue and the biochemical basis of diabetic complications","volume":"318","author":"Brownlee","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2005.03.023_bib4","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/sj.bjp.0702715","article-title":"In vivo B1 kinin-receptor upregulation. Evidence for involvement of protein kinases and nuclear factor kappaB pathways","volume":"127","author":"Campos","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib5","first-page":"237","article-title":"Treatment for diabetic nephropathy\u2014a review of the recent patent literature","volume":"5","author":"Candido","year":"2002","journal-title":"IDrugs"},{"key":"10.1016\/j.ejphar.2005.03.023_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0952-3278(96)90080-0","article-title":"Endothelial dysfunction in diabetes mellitus","volume":"54","author":"Chakir","year":"1996","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.ejphar.2005.03.023_bib7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S1567-5769(02)00188-1","article-title":"Diabetes modulates the expression of glomerular kinin receptors","volume":"2","author":"Christopher","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib8","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0002-9149(73)80051-7","article-title":"Diabetes and hypertensive vascular disease. Mechanism and treatment","volume":"32","author":"Christrieb","year":"1973","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(01)01318-8","article-title":"Kinins receptors in pain in inflammation","volume":"429","author":"Couture","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.diabres.2004.02.002","article-title":"Vascular endothelial growth factor in diabetes induced early retinal abnormalities","volume":"65","author":"Cukiernik","year":"2004","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ejphar.2005.03.023_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1139\/y03-022","article-title":"Mechanisms and consequences of large artery rigidity","volume":"81","author":"El-Taouil","year":"2003","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib13","first-page":"161","article-title":"Clinical and morphological features of human hypertensive-diabetic cardiomyopathy","volume":"34","author":"Factor","year":"1980","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejphar.2005.03.023_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0162-3109(99)00052-1","article-title":"Comparison of the responses of B1 and B2 kinin receptors to agonist stimulation","volume":"45","author":"Faussner","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ejphar.2005.03.023_bib15","first-page":"H817","article-title":"Diabetic cardiomyopathy in rats: mechanical and biochemical response to different insulin doses","volume":"247","author":"Fein","year":"1984","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2005.03.023_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(02)02658-4","article-title":"Role of bradykinin receptors in diabetes-induced hyperalgesia in streptozotocin-treated rat","volume":"457","author":"Gabra","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0143-4179(02)00148-8","article-title":"Kinin B1 receptor antagonist inhibit diabetes-induced hyperalgesia in mice","volume":"37","author":"Gabra","year":"2003","journal-title":"Neuropepetides"},{"key":"10.1016\/j.ejphar.2005.03.023_bib18","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.peptides.2003.06.003","article-title":"Beneficial effect of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-954, in attenuating streptozotocin-diabetic thermal hyperalgesia in mice","volume":"24","author":"Gabra","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2005.03.023_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.regpep.2004.12.003","article-title":"Absence of diabetic hyperalgesia in bradykinin B1 receptor-knockout mice","volume":"127","author":"Gabra","year":"2005","journal-title":"Regul. Pept."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2005.03.023_bib20","first-page":"S37","article-title":"The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications","volume":"49","author":"Haluzik","year":"2000","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2005.03.023_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00004872-199505000-00008","article-title":"Vascular albumin and hypertrophy in a rat model combining streptozotocin-induced diabetes and genetic hypertension","volume":"13","author":"Hulth\u00e9n","year":"1995","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2005.03.023_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF00400414","article-title":"Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM","volume":"39","author":"Hussain","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2005.03.023_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/ndt\/11.supp5.72","article-title":"Interactions between the sorbitol pathway, non-enzymatic glycation, and diabetic vascular dysfunction","volume":"S5","author":"Ido","year":"1996","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ejphar.2005.03.023_bib24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2337\/diabetes.44.2.156","article-title":"Kinin, a mediator of diabetes-induced glomerular hyperfiltration","volume":"44","author":"Jaffa","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2005.03.023_bib25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1139\/y03-053","article-title":"Endothelins in chronic diabetic complications","volume":"81","author":"Khan","year":"2003","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1165\/ajrcmb.22.1.3752","article-title":"Bradykinin stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activity","volume":"22","author":"Koyama","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib27","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.4049\/jimmunol.160.3.1419","article-title":"Role of the mitogen-activated protein kinases in the expression of the kinin B1 receptors induced by tissue injury","volume":"160","author":"Larrivee","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.regpep.2004.09.002","article-title":"Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist","volume":"124","author":"Lawson","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2005.03.023_bib29","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1139\/y02-024","article-title":"Induction of B1 receptors in streptozotocin diabetic rats: possible involvement in the control of hyperglycemia-induced glomerular Erk 1 and 2 phosphorylation","volume":"80","author":"Mage","year":"2002","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib30","first-page":"385","article-title":"Kinin receptors","volume":"16","author":"Marceau","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2005.03.023_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.pa.29.040189.002015","article-title":"Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases","volume":"29","author":"Margolius","year":"1989","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0024-3205(01)01141-9","article-title":"Diabetes-related cardiomyopathy time dependent echography evaluation in an experimental rat model","volume":"69","author":"Mihm","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2005.03.023_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1139\/y02-053","article-title":"Kinin B1 receptor antagonists with multi-enzymatic resistance properties","volume":"80","author":"Neugebauer","year":"2002","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib34","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1074\/jbc.273.5.2784","article-title":"Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation","volume":"273","author":"Ni","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.03.023_bib35","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1097\/00001756-200411150-00006","article-title":"Expression of kinin B1 receptors in the spinal cord of streptozotocin-diabetic rat","volume":"15","author":"Ongali","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2005.03.023_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/mol.56.2.325","article-title":"Autoregulation of bradykinin receptors: agonists in the presence of interleukin-1beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts","volume":"56","author":"Phagoo","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib37","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1139\/y96-090","article-title":"Consequences of alteration in capillary permeability","volume":"74","author":"Plante","year":"1996","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/BF00277315","article-title":"Endothelial cell function in diabetic micro-angiopathy","volume":"30","author":"Porta","year":"1987","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2005.03.023_bib39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1099-0895(199806)14:2<129::AID-DMR208>3.0.CO;2-V","article-title":"An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus","volume":"14","author":"Rabinovitch","year":"1998","journal-title":"Diabetes\/Metab Rev."},{"key":"10.1016\/j.ejphar.2005.03.023_bib40","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0006-2952(97)00492-9","article-title":"Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus","volume":"55","author":"Rabinovitch","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib41","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1464-5491.1993.tb00099.x","article-title":"Indomethacin but not metoprolol reduces exercise-induced albumin excretion rate in type 1 diabetic patients with microalbuminuria","volume":"10","author":"Rudberg","year":"1993","journal-title":"Diabet. Med."},{"key":"10.1016\/j.ejphar.2005.03.023_bib42","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1172\/JCI119229","article-title":"Vascular hypertrophy in Experimental diabetes","volume":"99","author":"Rumble","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.03.023_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(98)00609-8","article-title":"Bradykinin B1 receptors in human umbilical vein: pharmacological evidence of up-regulation, and induction by interleukin-1 beta","volume":"358","author":"Sardi","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000064682","article-title":"Left ventricular diastolic dysfunction as an early manifestation of diabetes cardiomyopahty","volume":"98","author":"Schannwell","year":"2002","journal-title":"Cardiology"},{"key":"10.1016\/j.ejphar.2005.03.023_bib45","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1172\/JCI1359","article-title":"The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts","volume":"101","author":"Schanstra","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.03.023_bib46","first-page":"304","article-title":"Intimal permeability evaluated in a short-term organ culture of diabetic guinea pig aorta","volume":"15","author":"Schlosser","year":"1988","journal-title":"Artery"},{"key":"10.1016\/j.ejphar.2005.03.023_bib47","first-page":"422","article-title":"Mechanism underlying enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice","volume":"24","author":"Shen","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2005.03.023_bib48","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1139\/y02-153","article-title":"Inhibitory effect of a novel bradykinin receptor B1 receptor antagonist, R-954, on enhanced vascular permeability in type 1 diabetic mice","volume":"80","author":"Simard","year":"2002","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0167-0115(00)00131-2","article-title":"Influence of secretin and l-NAME on vascular permeability in the coronary circulation of intact and diabetic rats","volume":"96","author":"Sitniewska","year":"2001","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2005.03.023_bib50","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s001250100588","article-title":"Constitutive nitric oxide synthase is associated with retinal vascular permeability in early diabetic rats","volume":"44","author":"Takeda","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2005.03.023_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/1056-8727(92)90035-J","article-title":"Interactions between hypertension and diabetes on vascular function and structure in rats","volume":"6","author":"Tilton","year":"1992","journal-title":"J. Diabetes Its Complicat."},{"key":"10.1016\/j.ejphar.2005.03.023_bib52","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0162-3109(96)00094-X","article-title":"Bradykinin excretion is increased in severely hyperglycemic streptozotocin-diabetic rats","volume":"33","author":"Tschope","year":"1996","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ejphar.2005.03.023_bib56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.bjp.0704999","article-title":"Up-regulation of kinin B1 receptor in the lung of streptozotocin-diabetic rat: autoradiographic and functional evidence","volume":"138","author":"Vianna","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0014-2999(98)00964-9","article-title":"Effects of the orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma extravasation in guinea pig airways","volume":"367","author":"Watanabe","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.03.023_bib54","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.2174\/1381612043383142","article-title":"Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide","volume":"10","author":"Wilkinson-Berka","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2005.03.023_bib55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/dmr.5610040404","article-title":"Basement membrane abnormalities in diabetes mellitus: relationship to clinical micro-angiopathy","volume":"4","author":"Williamson","year":"1988","journal-title":"Diabetes\/Metab Rev."},{"key":"10.1016\/j.ejphar.2005.03.023_bib57","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2337\/diabetes.48.4.855","article-title":"Hyperglycemia-induced activation of nuclear transcription factor kappa B in vascular smooth muscle cells","volume":"48","author":"Yerneni","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2005.03.023_bib58","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/bj3300361","article-title":"Roles for interleukin-1beta, phorbol ester and a post-transcriptional regulator in the control of bradykinin B1 receptor gene expression","volume":"330","author":"Zhou","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2005.03.023_bib59","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1139\/y96-047","article-title":"Effects of B1 and B2 kinin receptor antagonists in diabetic mice","volume":"74","author":"Zuccollo","year":"1996","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.03.023_bib60","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0162-3109(99)00149-6","article-title":"The involvement of kallikrein-kinin system in diabetes type I (insulitis)","volume":"45","author":"Zuccollo","year":"1999","journal-title":"Immunopharmacology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905003213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905003213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T01:26:13Z","timestamp":1683077173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299905003213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0014299905003213"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.03.023","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}