{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:02:44Z","timestamp":1790884964931,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.ejphar.2005.04.037","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T15:01:28Z","timestamp":1117206088000},"page":"118-124","source":"Crossref","is-referenced-by-count":22,"title":["4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and \u0394F508 CFTR"],"prefix":"10.1016","volume":"516","author":[{"given":"Meena","family":"Murthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Pedemonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"MacVinish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Galietta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Cuthbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.04.037_bib1","doi-asserted-by":"crossref","first-page":"27415","DOI":"10.1074\/jbc.274.39.27415","article-title":"Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel","volume":"274","author":"Becq","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.04.037_bib2","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1074\/jbc.M412972200","article-title":"Curcumin stimulates CFTR Cl\u2212 channel activity","volume":"280","author":"Berger","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.04.037_bib3","first-page":"L180","article-title":"CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds","volume":"285","author":"Caci","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib4","doi-asserted-by":"crossref","first-page":"C46","DOI":"10.1152\/ajpcell.2001.281.1.C46","article-title":"ClC-2 Cl\u2212 channels in human lung epithelia: activation by arachidonic acid, amidation, and acid activated omeprazole","volume":"281","author":"Cuppoletti","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib5","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.bjp.0705203","article-title":"Benzoquinolines and chloride secretion in murine colonic epithelium","volume":"138","author":"Cuthbert","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sj.bjp.0705403","article-title":"Mechanisms of anion secretion in Calu-3 human epithelial cells by 7,8-benzoquinoline","volume":"140","author":"Cuthbert","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1113\/jphysiol.2003.046482","article-title":"Bicarbonate-dependent chloride secretion in Calu-3 epithelia in response to 7,8-benzoquinoline","volume":"551","author":"Cuthbert","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00232-003-2030-z","article-title":"Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004","volume":"194","author":"Dearand","year":"2003","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib9","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/358761a0","article-title":"Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive","volume":"358","author":"Denning","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2005.04.037_bib10","first-page":"L775","article-title":"Modification of Cl\u2212 secretion by benzimidazolones: I. Direct activation of a Ca2+-dependent K+ channel","volume":"271","author":"Devor","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib11","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.bjp.0704328","article-title":"Phenanthrolines\u2014a new class of CFTR chloride channel openers","volume":"134","author":"Duszyk","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.04.037_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng1192-240","article-title":"Submucosal glands are the predominant site of CFTR expression in human bronchus","volume":"2","author":"Engelhardt","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejphar.2005.04.037_bib13","doi-asserted-by":"crossref","first-page":"19723","DOI":"10.1074\/jbc.M101892200","article-title":"Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds","volume":"276","author":"Galietta","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.04.037_bib14","doi-asserted-by":"crossref","first-page":"37235","DOI":"10.1074\/jbc.M205932200","article-title":"High affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening","volume":"277","author":"Ma","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.04.037_bib15","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/jm0308848","article-title":"Synthesis, SAR, crystal structure and biological activation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels","volume":"47","author":"Marivingt-Mounir","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2005.04.037_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0005-2736(99)00110-8","article-title":"Activation of the human intermediate conductance Ca2+-activated K+ channel by 1-ethyl-benzimidazolone is strongly Ca2+-dependent","volume":"1420","author":"Pedersen","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2005.04.037_bib17","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1016\/S0968-0896(03)00435-8","article-title":"Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: Towards a pharmacophore model for the nucleotide-binding domain","volume":"11","author":"Springsteel","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2005.04.037_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/sj.bjp.0705846","article-title":"4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells","volume":"142","author":"Szkotak","year":"2004","journal-title":"Br. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905004632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905004632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T23:47:37Z","timestamp":1550792857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299905004632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0014299905004632"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.04.037","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}