{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:49:14Z","timestamp":1762112954129},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.ejphar.2005.04.045","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T16:22:27Z","timestamp":1119457347000},"page":"239-246","source":"Crossref","is-referenced-by-count":37,"title":["Panicolytic-like effect induced by the stimulation of GABAA and GABAB receptors in the dorsal periaqueductal grey of rats"],"prefix":"10.1016","volume":"516","author":[{"given":"C\u00edntia H.","family":"Bueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"H\u00e9lio","family":"Zangrossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina L.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa P.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena B.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.04.045_bib1","first-page":"66","article-title":"Single neuron analysis of the human midbrain tegmentum: rostral mesencephalic reliculotomy of pain relief","volume":"41","author":"Amano","year":"1978","journal-title":"Appl. Neurophysiol."},{"key":"10.1016\/j.ejphar.2005.04.045_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0014-2999(87)90615-7","article-title":"GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA","volume":"135","author":"Audi","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.04.045_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(94)90047-7","article-title":"Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?","volume":"17","author":"Bandler","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2005.04.045_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF02245294","article-title":"Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray","volume":"108","author":"Beckett","year":"1992","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2005.04.045_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0006-8993(82)90589-3","article-title":"Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region","volume":"248","author":"Bovier","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0306-4522(87)90098-4","article-title":"GABAA e GABAB receptor distribution in the rat central nervous system","volume":"20","author":"Bowery","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2005.04.045_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-2999(03)01284-6","article-title":"The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations","volume":"463","author":"Brand\u00e3o","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.04.045_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1176\/ajp.146.3.353","article-title":"Role of gamma-aminobutyric acid in antipanic drug efficacy","volume":"146","author":"Breslow","year":"1989","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2005.04.045_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/026988119100500414","article-title":"5-HT and mechanisms of defense","volume":"5","author":"Deakin","year":"1991","journal-title":"J. Psychopharmacol. (Berl)"},{"key":"10.1016\/j.ejphar.2005.04.045_bib10","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/00004850-199804004-00005","article-title":"Review of current treatment in panic disorder","volume":"13","author":"Den Boer","year":"1998","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2005.04.045_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0140-6736(83)90076-4","article-title":"Severe anxiety induced by FG 7142 a beta carboline ligand for benzodiazepine receptors","volume":"8342","author":"Dorow","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.04.045_bib12","series-title":"The Midbrain Periaqueductal Matter: Functional, Anatomical and Immunohistochemical Organization","first-page":"151","article-title":"The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety","author":"Fanselow","year":"1991"},{"key":"10.1016\/j.ejphar.2005.04.045_bib13","series-title":"Handbook of Anxiety","first-page":"307","article-title":"Brain defense systems and anxiety","volume":"vol. 3","author":"Graeff","year":"1990"},{"key":"10.1016\/j.ejphar.2005.04.045_bib14","series-title":"Biological Psychiatric","first-page":"1","article-title":"Animal models of anxiety","author":"Graeff","year":"2002"},{"key":"10.1016\/j.ejphar.2005.04.045_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0166-4328(86)90038-0","article-title":"Modulation of the brain aversive system by GABAergic and serotonergic mechanisms","volume":"22","author":"Graeff","year":"1986","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0166-4328(93)90097-A","article-title":"Role of the amygdala and periaqueductal gray in anxiety and panic","volume":"58","author":"Graeff","year":"1993","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0149-7634(98)00024-4","article-title":"The elevated T-maze as an experimental model of anxiety","volume":"23","author":"Graeff","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2005.04.045_bib18","series-title":"The Neuropsychology of Anxiety","author":"Gray","year":"2001"},{"key":"10.1016\/j.ejphar.2005.04.045_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/1056-8719(93)90063-K","article-title":"An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs","volume":"29","author":"Handley","year":"1993","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejphar.2005.04.045_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0165-1781(95)02673-K","article-title":"Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity","volume":"57","author":"Jenck","year":"1995","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00008877-200211000-00002","article-title":"Further evidence for the predictive validity of the unstable elevated exposed plus-maze, a behavioural model of extreme anxiety in rats: differential effects of fluoxetine and chlordiazepoxide","volume":"13","author":"Jones","year":"2002","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.04.045_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0091-3057(00)00435-4","article-title":"Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug","volume":"68","author":"Jung","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0006-8993(93)91574-C","article-title":"Serotonergic influence from nucleus raphe obscurus on neurones in the periaqueductal grey matter in the rat","volume":"606","author":"Lovick","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib24","first-page":"48","article-title":"Panic disorder-A malfunction of multiple transmitter control system within the midbrain periaqueductal gray matter?","volume":"6","author":"Lovick","year":"2000","journal-title":"Neurosci."},{"key":"10.1016\/j.ejphar.2005.04.045_bib25","series-title":"GABAA Receptors and Anxiety: from Neurobiology to Treatment","first-page":"115","article-title":"Benzodiazepine receptor function in anxiety disorder","author":"Malizia","year":"1995"},{"key":"10.1016\/j.ejphar.2005.04.045_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3171\/jns.1969.30.1.0014","article-title":"Sensations evoked by stimulation in the midbrain of man","volume":"30","author":"Nashold","year":"1969","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.ejphar.2005.04.045_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(94)00402-5","article-title":"Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion","volume":"52","author":"Nogueira","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/ajplegacy.1962.203.5.803","article-title":"Approach-escape interactions in rat brain","volume":"203","author":"Olds","year":"1962","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.04.045_bib29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1017\/S0140525X00012759","article-title":"Toward a general psychobiological theory of emotions","volume":"5","author":"Panksepp","year":"1982","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.ejphar.2005.04.045_bib30","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.ejphar.2005.04.045_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(03)00151-7","article-title":"Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze","volume":"147","author":"Poltronieri","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib32","first-page":"607","article-title":"Anxiolytic effect of midazolam microinjected into the dorsal periaqueductal grey area of rats","volume":"24","author":"Russo","year":"1991","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF02246973","article-title":"Role of benzodiazepine receptors located in the dorsal periaqueductal grey of rats in anxiety","volume":"110","author":"Russo","year":"1993","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2005.04.045_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0031-9384(87)90231-9","article-title":"Mapping of jumping, rearing, squealing and switch-off behaviors elicited by periaqueductal gray stimulation in the rat","volume":"39","author":"Sandner","year":"1987","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0091-3057(78)90287-3","article-title":"Role of the periaqueductal gray substance in the antianxiety action of benzodiazepines","volume":"9","author":"Schenberg","year":"1978","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0031-9384(83)90062-8","article-title":"GABA modulation of the defense reaction induced by brain electrical stimulation","volume":"31","author":"Schenberg","year":"1983","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0149-7634(01)00060-4","article-title":"Modeling panic attacks","volume":"25","author":"Schenberg","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2005.04.045_bib38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF00428199","article-title":"Anti-aversive role of serotonin in the dorsal periaqueductal grey matter","volume":"85","author":"Schutz","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2005.04.045_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0166-4328(02)00399-6","article-title":"The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats","volume":"142","author":"Sena","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2005.04.045_bib40","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0091-3057(99)00261-0","article-title":"Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety","volume":"65","author":"Teixeira","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0091-3057(94)90067-1","article-title":"The elevated T-maze: a new animal model of anxiety and memory","volume":"49","author":"Viana","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2005.04.045_bib42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(03)01970-8","article-title":"Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze","volume":"473","author":"Zanoveli","year":"2003","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905005005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905005005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T17:13:13Z","timestamp":1551287593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299905005005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0014299905005005"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.04.045","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}