{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:22:48Z","timestamp":1759530168078},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.ejphar.2005.05.013","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:38:07Z","timestamp":1119375487000},"page":"186-190","source":"Crossref","is-referenced-by-count":17,"title":["Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats"],"prefix":"10.1016","volume":"517","author":[{"given":"Gilberto N.","family":"Carmona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles W.","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel H.","family":"Greig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Jufer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Cone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Gorelick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.05.013_bib1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1099-081X(199807)19:5<309::AID-BDD108>3.0.CO;2-9","article-title":"The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma","volume":"19","author":"Browne","year":"1998","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejphar.2005.05.013_bib2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0024-3205(96)00392-X","article-title":"Plasma butyrylcholinesterase activity and cocaine half-life differ significantly in rhesus and squirrel monkeys","volume":"59","author":"Carmona","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2005.05.013_bib3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1037\/1064-1297.6.3.274","article-title":"Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase","volume":"6","author":"Carmona","year":"1998","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib4","first-page":"367","article-title":"Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans","volume":"28","author":"Carmona","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2005.05.013_bib5","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/clinchem\/40.7.1299","article-title":"Simultaneous measurement of cocaine, cocaethylene, their metabolites, and \u201ccrack\u201d pyrolysis products by gas chromatography-mass spectrometry","volume":"40","author":"Cone","year":"1994","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ejphar.2005.05.013_bib6","first-page":"179","article-title":"Inhibition of the metabolism of cocaine by SKF-525A","volume":"17","author":"Estevez","year":"1977","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib7","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1124\/jpet.104.068122","article-title":"An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats","volume":"310","author":"Gao","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.05.013_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0376-8716(97)00119-1","article-title":"Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy","volume":"48","author":"Gorelick","year":"1997","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2005.05.013_bib9","first-page":"698","article-title":"Decreased plasma cholinesterase activity enhances cocaine toxicity in mice","volume":"263","author":"Hoffman","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.05.013_bib10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/15563659609013786","article-title":"Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice","volume":"34","author":"Hoffman","year":"1996","journal-title":"J. Toxicol., Clin. Toxicol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1081\/CLT-120039540","article-title":"Ecgonine methyl ester protects against cocaine lethality in mice","volume":"42","author":"Hoffman","year":"2004","journal-title":"J. Toxicol., Clin. Toxicol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib12","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1139\/y89-184","article-title":"Cocaine: pharmacokinetics and biotransformation in man","volume":"67","author":"Inaba","year":"1989","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2005.05.013_bib13","first-page":"553","article-title":"Inhibition of pseudocholinesterase activity protects from cocaine-induced cardiorespiratory toxicity in rats","volume":"119","author":"Kambam","year":"1992","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2005.05.013_bib14","first-page":"188","article-title":"The effects of inhibition of plasma cholinesterase activity on systemic toxicity and blood catecholamine levels from cocaine infusion in pigs","volume":"122","author":"Kambam","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2005.05.013_bib15","first-page":"R103","article-title":"Role of cholinergic receptors and cholinesterase activity in hemodynamic responses to cocaine in conscious rats","volume":"276","author":"Knuepfer","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib16","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1124\/dmd.30.6.716","article-title":"Characterization of butyrylcholinesterase antagonism of cocaine-induced hyperactivity","volume":"30","author":"Koetzner","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2005.05.013_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/taap.1997.8187","article-title":"Cocaine detoxification by human plasma butyrylcholinesterase","volume":"145","author":"Lynch","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0379-0738(84)90215-9","article-title":"In vivo and in vitro studies on cocaine metabolism: ecgonine methyl ester as a major metabolite of cocaine","volume":"26","author":"Matsubara","year":"1984","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.ejphar.2005.05.013_bib19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1006\/taap.1997.8188","article-title":"Therapeutic use of butyrylcholinesterase for cocaine intoxication","volume":"145","author":"Mattes","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.05.013_bib20","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"1996"},{"key":"10.1016\/j.ejphar.2005.05.013_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0361-9230(95)02040-3","article-title":"Effect of cocaine metabolites on behavior: possible neuroendocrine mechanisms","volume":"39","author":"Schuelke","year":"1996","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2005.05.013_bib22","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1124\/jpet.302.2.710","article-title":"Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase","volume":"302","author":"Sun","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.05.013_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00007691-200006000-00006","article-title":"Mechanisms of cocaine hydrolysis and metabolism in vitro and in vivo: a clarification","volume":"22","author":"Warner","year":"2000","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejphar.2005.05.013_bib24","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1021\/jm980459s","article-title":"Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease","volume":"42","author":"Yu","year":"1999","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905005522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905005522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T21:52:46Z","timestamp":1586296366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299905005522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0014299905005522"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.05.013","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}