{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:31:53Z","timestamp":1773477113666,"version":"3.50.1"},"reference-count":140,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.ejphar.2005.12.060","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T12:21:15Z","timestamp":1140092475000},"page":"15-27","source":"Crossref","is-referenced-by-count":67,"title":["\u03b2-Adrenoceptor responses of the airways: For better or worse?"],"prefix":"10.1016","volume":"533","author":[{"given":"Kenneth J.","family":"Broadley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2005.12.060_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/02770909009073289","article-title":"Skeletal muscle tremor and the influence of adrenergic drugs","volume":"27","author":"Ahrens","year":"1990","journal-title":"J. Asthma"},{"key":"10.1016\/j.ejphar.2005.12.060_bib2","first-page":"L193","article-title":"Mast cell tryptase stimulates human lung, fibroblast proliferation via a protease-activated receptor-2","volume":"278","author":"Akers","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-0773.1988.tb01839.x","article-title":"Time course of resensitization of rat uterine \u03b2-adrenoceptor system","volume":"62","author":"Andersson","year":"1988","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib4","first-page":"70","article-title":"Preventing acute decline in isoprenaline inotropism","volume":"39","author":"Argent","year":"1997","journal-title":"Pharmacologist"},{"key":"10.1016\/j.ejphar.2005.12.060_bib5","first-page":"216P","article-title":"In vitro desensitization of atrial \u03b21-adrenoceptor function: effects of PDE inhibition","volume":"126","author":"Asmawi","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"4 Pt 1","key":"10.1016\/j.ejphar.2005.12.060_bib6","first-page":"L461","article-title":"The \u03b22-adrenergic receptor agonist formoterol reduces microvascular bleakage by inhibiting endothelial gap formation","volume":"266","author":"Baluk","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib7","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1476-5381.1996.tb16030.x","article-title":"The effect of selective phosphodiesterase 3 and 4 isoenzyme inhibitors and established anti-asthma drugs on inflammatory cell activation","volume":"119","author":"Banner","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1164\/ajrccm.152.3.7663795","article-title":"Beta-adrenergic receptors and their regulation","volume":"152","author":"Barnes","year":"1995","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2005.12.060_bib11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2125.1983.tb01549.x","article-title":"Dose\u2013response curves to inhaled beta-adrenoceptor agonists in normal and asthmatic subjects","volume":"15","author":"Barnes","year":"1983","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0165-6147(92)90011-T","article-title":"Questions about inhaled \u03b22-adrenoceptor agonists in asthma","volume":"13","author":"Barnes","year":"1992","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2005.12.060_bib10","series-title":"Asthma and COPD. Basic Mechanisms and Clinical Management","first-page":"343","article-title":"Pathophysiology of asthma","author":"Barnes","year":"2002"},{"key":"10.1016\/j.ejphar.2005.12.060_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0014-2999(92)90676-U","article-title":"Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans","volume":"210","author":"Belvisi","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib13","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1164\/ajrccm.155.4.9105089","article-title":"Salmeterol reduces early- and late-phase plasma leakage and leukocyte adhesion in rat airways","volume":"155","author":"Bolton","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2125.2004.02261.x","article-title":"Measuring bronchodilation in COPD clinical trials","volume":"59","author":"Borrill","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib137","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1081\/JAS-120023584","article-title":"Airway responsiveness to beta-adrenergic agonist (salbutamol) in asthma","volume":"40","author":"Boskabady","year":"2003","journal-title":"J. Asthma"},{"key":"10.1016\/j.ejphar.2005.12.060_bib15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1046\/j.1365-2222.2001.01014.x","article-title":"Effect of sameterol on allergen-induced airway inflammation in mild allergic asthma","volume":"31","author":"Boulet","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2005.12.060_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2165\/00003088-200140010-00003","article-title":"The pharmacokinetics of levosalbutamol: what are the clinical implications?","volume":"40","author":"Boulton","year":"2001","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejphar.2005.12.060_bib17","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"Asthma: from bronchoconstriction to airway inflammation and remodelling","volume":"161","author":"Bousquet","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"S1","key":"10.1016\/j.ejphar.2005.12.060_bib18","first-page":"i1","article-title":"Guidelines on the management of asthma","volume":"58","author":"British Thoracic Society","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2005.12.060_bib19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/thx.43.4.300","article-title":"Dose related effects of salbutamol and ipratropium bromide on airway calibre and reactivity in subjects with asthma","volume":"43","author":"Britton","year":"1988","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2005.12.060_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2680.1999.tb00006.x","article-title":"Review of mechanisms involved in the apparent differential desensitization of \u03b21- and \u03b22-adrenoceptor-mediated functional responses","volume":"19","author":"Broadley","year":"1999","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1139\/y94-024","article-title":"Does endogenous adenosine have a role in the cardiac responses to isoprenaline and the rapid fade of the inotropic response of perfused heart?","volume":"72","author":"Broadley","year":"1994","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1165\/ajrcmb.13.2.7626290","article-title":"Tryptase, the dominant secretory granule protein in human mast cells, is a potent mitogen for cultured dog trachea smooth muscle cells","volume":"13","author":"Brown","year":"1995","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib23","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1476-5381.1991.tb12487.x","article-title":"Salmeterol, a potent and long-acting inhibitor of inflammatory mediator release from human lung","volume":"104","author":"Butchers","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1159\/000053783","article-title":"(S)-albuterol increases the production of histamine and IL-4 in mast cells","volume":"124","author":"Cho","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(99)00425-2","article-title":"\u03b2-adrenoceptor reserve in human lung: a comparison between airway smooth muscle and mast cells","volume":"378","author":"Chong","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00008571-200003000-00007","article-title":"Influence of genetic polymorphism in the \u03b22-adrenoceptor on desensitization in human lung mast cells","volume":"10","author":"Chong","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.ejphar.2005.12.060_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(02)01263-3","article-title":"Pharmacological characterisation of the \u03b2-adrenoceptor expressed by human lung mast cells","volume":"437","author":"Chong","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib28","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/sj.bjp.0705050","article-title":"Desensitization of \u03b2-adrenoceptor-mediated responses by short-acting \u03b2-adrenoceptor agonists in human lung mast cells","volume":"138","author":"Chong","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2165\/00151829-200403050-00002","article-title":"Combination therapy of long-acting \u03b22-adrenoceptor agonists and corticosteroids for asthma","volume":"3","author":"Chung","year":"2004","journal-title":"Treat. Respir. Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1476-5381.1987.tb08972.x","article-title":"Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol","volume":"90","author":"Church","year":"1987","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib31","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1172\/JCI115929","article-title":"Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophils superoxide anion production via a direct action on the NADPH oxidase","volume":"90","author":"Clancy","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.12.060_bib32","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0091-6749(87)90204-1","article-title":"Comparative effects of inhaled salbutamol, sodium cromoglycate and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine","volume":"79","author":"Cockcroft","year":"1987","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib33","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0140-6736(93)92695-P","article-title":"Regular inhaled salbutamol and airway responsiveness to allergen","volume":"342","author":"Cockcroft","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.12.060_bib34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.bjp.0704295","article-title":"Nitric oxide regulates eosinophils adhesion mechanisms in vitro by changing integrin expression and activity on the eosinophils cell surface","volume":"134","author":"Conran","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib35","first-page":"45","article-title":"Prescribed fenoterol and death from asthma in New Zealand, 1981\u201383: a case\u2013control study","volume":"1","author":"Crane","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.12.060_bib138","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pupt.2004.01.005","article-title":"One week treatment with salmeterol does not prevent early and late asthmatic responses and sputum eosinophilia induced by allergen challenge in asthmatics","volume":"17","author":"Dente","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.bjp.0701897","article-title":"Influence of receptor reserve on \u03b2-adrenoceptor-mediated responses in human mast cells","volume":"124","author":"Drury","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1476-5381.1994.tb14025.x","article-title":"The dose-related hyper- and hypokalaemic effects of salbutamol and its arrhythmogenic potential","volume":"111","author":"Du Plooy","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2222.1985.tb02290.x","article-title":"Eosinophils, bronchial hyperreactivity and late-asthmatic reactions","volume":"15","author":"Durham","year":"1985","journal-title":"Clin. Allergy"},{"issue":"suppl","key":"10.1016\/j.ejphar.2005.12.060_bib39","first-page":"77","article-title":"Subclasses of beta-adrenoceptors \u2014 a quantitative estimation of beta1- and \u03b22-adrenoceptors in guinea pig and human lung","volume":"57","author":"Engel","year":"1981","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.ejphar.2005.12.060_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-2999(88)90376-7","article-title":"Adrenoceptor desensitization in guinea-pig isolated trachea","volume":"157","author":"Fernandez","year":"1988","journal-title":"Eur. J. Pharmacol."},{"issue":"suppl 2","key":"10.1016\/j.ejphar.2005.12.060_bib41","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000195127","article-title":"Histamine-induced bronchial response after administration of placebo, salbutamol and a combination of a beta-2 adrenergic drug (fenoterol) with an anticholinergic agent (ipratropium bromide) in asymptomatic asthma patients","volume":"50","author":"Fontana","year":"1986","journal-title":"Respiration"},{"issue":"Suppl 1","key":"10.1016\/j.ejphar.2005.12.060_bib42","first-page":"S19","article-title":"Combined bronchodilator therapy in the management of chronic obstructive pulmonary disease","volume":"2","author":"Friedman","year":"1997","journal-title":"Respirology"},{"key":"10.1016\/j.ejphar.2005.12.060_bib43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0952-0600(88)80006-1","article-title":"Human alveolar macrophage activation: inhibition by forskolin but not \u03b2-adrenoceptor stimulation or phosphodiesterase inhibition","volume":"1","author":"Fuller","year":"1988","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib44","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1164\/ajrccm.156.6.96-08042","article-title":"Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthma subjects","volume":"156","author":"Gauvreau","year":"1997","journal-title":"Am. Rev. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0165-6147(96)10039-0","article-title":"Phosphodiesterase 4 and tolerance to \u03b22-adrenoceptor agonists in asthma","volume":"17","author":"Giembycz","year":"1996","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2005.12.060_bib46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/thx.46.2.105","article-title":"Prescribed fenoterol and death from asthma in New Zealand, 1981\u20137: further case\u2013control study","volume":"46","author":"Grainger","year":"1991","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2005.12.060_bib47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0076-6879(96)69044-2","article-title":"Nitric oxide as anti-inflammatory agent","volume":"269","author":"Granger","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib48","first-page":"13572","article-title":"A polymorphism of the human \u03b22-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor","volume":"264","author":"Green","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2005.12.060_bib49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1165\/ajrcmb\/8.5.518","article-title":"Effect of salbutamol, fenoterol, and sodium cromoglycate on the release of heparin from sensitized human lung fragments challenged with Dermatophagoides pteronyssinus allergen","volume":"8","author":"Green","year":"1993","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1165\/ajrcmb.13.1.7598936","article-title":"Influence of \u03b22-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells","volume":"13","author":"Green","year":"1995","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/thx.51.1.54","article-title":"Evaluation of the \u03b22-adrenoceptor agonist\/antagonist activity of formoterol and salmeterol","volume":"51","author":"Grove","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2005.12.060_bib52","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0140-6736(95)91994-5","article-title":"Association of thye Glu 27 \u03b22-adrenoceptor polymorphism with lower airway reactivity in asthma subjects","volume":"345","author":"Hall","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.12.060_bib53","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.rmed.2004.10.014","article-title":"Rapid onset tolerance to \u03b2-agonist bronchodilation","volume":"99","author":"Haney","year":"2005","journal-title":"Respir. Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1440-1711.2001.00983.x","article-title":"Regulation of the inflammatory response in asthma by mast cell products","volume":"79","author":"Hart","year":"2001","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib55","first-page":"986","article-title":"Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma","volume":"132","author":"Howarth","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2005.12.060_bib56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2165\/00002018-200427040-00003","article-title":"Benefit\u2013risk assessment of long-acting \u03b22-agonists in asthma","volume":"27","author":"Jackson","year":"2004","journal-title":"Drug Safety"},{"key":"10.1016\/j.ejphar.2005.12.060_bib57","first-page":"665","article-title":"Human lung mast cell IL-5 gene and protein expression: temporal analysis of upregulation following IgE-mediated activation","volume":"13","author":"Jaffe","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/thx.42.10.809","article-title":"Comparison of the effects of inhaled ipratropium bromide and salbutamol on the bronchoconstrictor response to hypocapnic hyperventilation in normal subjects","volume":"42","author":"Jameson","year":"1987","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2005.12.060_bib59","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1164\/ajrccm.158.supplement_2.13tac110","article-title":"The \u03b2-adrenoceptor","volume":"158","author":"Johnson","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib60","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/0024-3205(93)90728-L","article-title":"The pharmacology of salmeterol","volume":"52","author":"Johnson","year":"1993","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2005.12.060_bib61","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1183\/09031936.97.10010038","article-title":"Mast cell tryptase potentiates histamine-induced contraction in human sensitised bronchus","volume":"10","author":"Johnson","year":"1997","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2005.12.060_bib62","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/thorax.58.8.703","article-title":"Polymorphism in the \u03b22 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers","volume":"58","author":"Joos","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2005.12.060_bib63","doi-asserted-by":"crossref","unstructured":"Kanabar, V., Hirst, S.J., O'Connor, B.J., Page, C.P., 2005. Some structural determinants of the antiproliferative effect of heparin-like molecules on human airway smooth muscle. Br. J. Pharmacol. July 18 (electronic publication).","DOI":"10.1038\/sj.bjp.0706333"},{"key":"10.1016\/j.ejphar.2005.12.060_bib64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1567-5769(02)00217-5","article-title":"Influence of the thr164ile polymorphism in the \u03b22-adrenoceptor on the effects of \u03b2-adrenoceptor agonists on human lung mast cells","volume":"3","author":"Kay","year":"2003","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib65","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0091-6749(87)80163-X","article-title":"Effect of long-term treatment with inhaled corticosteroids and \u03b2-agonists on the bronchial responsiveness in children with asthma","volume":"79","author":"Kerrebijn","year":"1987","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib66","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/0091-6749(85)90786-9","article-title":"Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline","volume":"76","author":"Kraan","year":"1985","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/sj.bjp.0701338","article-title":"Effect of endogenous nitric oxide on tumour necrosis factor-\u03b1-induced leuko-sequestration and IL-8 release in guinea-pig airways in vivo","volume":"122","author":"Kuo","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib68","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.103.061739","article-title":"A nitric oxide-releasing salbutamol elicits potent relaxant and anti-inflammatory activities","volume":"310","author":"Lagente","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib69","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/pupt.2001.0296","article-title":"Glycosaminoglycans, airways inflammation and bronchial hyperresponsiveness","volume":"14","author":"Lever","year":"2001","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib70","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2165\/00003495-200565050-00001","article-title":"Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a clinical benefit?","volume":"65","author":"Man","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2005.12.060_bib71","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1472-8206.1995.tb00270.x","article-title":"\u03b23-adrenoceptors and the airways","volume":"9","author":"Martin","year":"1995","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1472-8206.1989.tb00670.x","article-title":"In vitro desensitization of \u03b2-adrenoceptors in guinea-pig trachea: interactions between \u03b2-adrenoceptor agonists and influence of adenosine and other drugs","volume":"3","author":"Matran","year":"1989","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib73","first-page":"1236","article-title":"Pharmacological modulation of immediate and late phase airway response and leukocyte infiltration","volume":"269","author":"Matsumoto","year":"1994","journal-title":"J. Pharmacol. Exp.Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib74","first-page":"1","article-title":"Role of combination inhaled corticosteroids and long acting \u03b2-agonists in the treatment of adult asthma","author":"Mayers","year":"2005","journal-title":"Issues Emerg. Health Technol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib75","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1164\/ajrccm\/139.3.801","article-title":"Toxicity of eosinophils cationic proteins for guinea pig tracheal epithelium in vitro","volume":"139","author":"Motojima","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2005.12.060_bib76","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11882-005-0085-x","article-title":"Combination therapy of long-acting \u03b2 agonists and inhaled cortocosteroids in the management of asthma","volume":"5","author":"Nelson","year":"2005","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.ejphar.2005.12.060_bib139","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0163-7258(02)00262-0","article-title":"Nitric oxide in respiratory diseases.","volume":"95","author":"Nevin","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib77","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-2999(94)90392-1","article-title":"Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol","volume":"251","author":"Nials","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib78","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1164\/ajrccm.159.6.9809090","article-title":"Differential effect of formoterol on adenosine monophosphate and histamine reactivity in asthma","volume":"159","author":"Nightingale","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib79","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1056\/NEJM199210223271704","article-title":"Tolerance to the non-bronchodilator effects of inhaled \u03b22-agonists","volume":"327","author":"O'Connor","year":"1992","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib80","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/pulp.1995.1032","article-title":"Inhaled albuterol does not inhibit cellular influx or lung injury produced by segmental antigen challenge in humans","volume":"8","author":"O'Connor","year":"1995","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib81","series-title":"Adrenoceptors: Structure, Mechanisms, Function, Advances in Pharmacological Sciences","first-page":"265","article-title":"Pharmacology of \u03b2-adrenoceptors in lung disease","author":"O'Donnell","year":"1991"},{"key":"10.1016\/j.ejphar.2005.12.060_bib82","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00501381","article-title":"The importance of choice of agonist in studies designed to predict \u03b22:\u03b21 adrenoceptor selectivity of antagonists from pA2 values in guinea-pig trachea and atria","volume":"308","author":"O'Donnell","year":"1979","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib83","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0140-6736(91)90289-2","article-title":"One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by \u03b22-agonists","volume":"337","author":"Page","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.12.060_bib84","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/S0091-6749(99)70271-X","article-title":"Contrasting properties of albuterol stereoisomers","volume":"104","author":"Page","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib86","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/0091-6749(88)91037-8","article-title":"The effect of ketotifen on bronchial beta-adrenergic tachyphylaxis in normal human volunteers","volume":"81","author":"Pauwels","year":"1988","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib85","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.163.5.2101039","article-title":"Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI\/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary","volume":"163","author":"Pauwels","year":"2001","journal-title":"Am. Rev. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib87","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(95)91159-6","article-title":"End of the New Zealand asthma mortality epidemic","volume":"345","author":"Pearce","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.12.060_bib88","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0014-2999(82)90351-X","article-title":"The control of mucin secretion into the lumen of the cat trachea by \u03b1- and \u03b2-adrenoceptors, and their relative involvementg during sympathetic nerve stimulation","volume":"81","author":"Peatfield","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib89","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1398-9995.1993.tb02410.x","article-title":"The effect of salmeterol on the early- and late-phase reaction to bronchial allergen and postchallenge variation in bronchial reactivity, blood eosinophils, serum eosinophil cationic protein, and serum eosinophils protein X","volume":"48","author":"Pedersen","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2005.12.060_bib90","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/cs0630023","article-title":"Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro","volume":"63","author":"Phipps","year":"1982","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ejphar.2005.12.060_bib91","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1183\/09031936.96.09030449","article-title":"Effect of salmeterol compared with beclomethasone on allergen-induced asthmatic and inflammatory responses","volume":"9","author":"Pizzichini","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2005.12.060_bib140","first-page":"429","article-title":"Pairwise comparison of levalbuterol versus racemic albuterol in the treatment of moderate-to-severe asthma","volume":"25","author":"Pleskow","year":"2004","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.ejphar.2005.12.060_bib92","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1183\/09031936.98.11051086","article-title":"Bronchodilator response to salbutamol after spontaneous recovery from non-specific bronchial provocation tests in asthma","volume":"11","author":"Polosa","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2005.12.060_bib93","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1046\/j.1365-2222.1998.00335.x","article-title":"Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration","volume":"28","author":"Proud","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2005.12.060_bib94","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1164\/ajrccm\/136.2.369","article-title":"The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine 5\u2032-monophosphate","volume":"136","author":"Rafferty","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2005.12.060_bib95","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s002280050640","article-title":"Bronchoprotective and bronchodilator effects of single doses of (S)-salbutamol, (R)-salbutamol and racemic salbutamol in patients with bronchila asthma","volume":"55","author":"Ramsay","year":"1999","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib96","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1165\/ajrcmb\/8.3.334","article-title":"Mutations in the gene encoding for the \u03b22-adrenergic receptor in normal and asthmatic subjects","volume":"8","author":"Reishaus","year":"1993","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib97","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0034-5687(00)00209-7","article-title":"Motor control of airways goblet cells and glands","volume":"125","author":"Rogers","year":"2000","journal-title":"Respir. Physiol."},{"issue":"suppl","key":"10.1016\/j.ejphar.2005.12.060_bib98","first-page":"S2","article-title":"Physiologic and pharmacologic control of mucus release","volume":"1032","author":"Samet","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ejphar.2005.12.060_bib99","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.bjp.0705905","article-title":"Influence of agonist intrinsic activity on the desensitisation of \u03b2-adrenoceptor-mediated responses in mast cells","volume":"143","author":"Scola","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.bjp.0705599","article-title":"Desensitization of mast cell \u03b2-adrenoceptor-mediated responses by salmeterol and formoterol","volume":"141","author":"Scola","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib101","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2165\/00002018-199411040-00005","article-title":"The \u03b22-agonist controversy. Observations, explanations and relationship to asthma epidemiology","volume":"11","author":"Sears","year":"1994","journal-title":"Drug Safety"},{"key":"10.1016\/j.ejphar.2005.12.060_bib102","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0140-6736(90)93098-A","article-title":"Regular inhaled \u03b2-agonist treatment in bronchial asthma","volume":"336","author":"Sears","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2005.12.060_bib103","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s000110050651","article-title":"Oral beta-stimulants can inhibit cutaneous anaphylaxis in rats through an indirect inhibitory mechanism: possible involvement of afferent and efferent nervous system via gastric \u03b22-adrenoceptor stimulation","volume":"49","author":"Shibata","year":"2000","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejphar.2005.12.060_bib104","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00008571-200309000-00002","article-title":"An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced \u03b22-adrenergic receptor stimulation","volume":"13","author":"Small","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.ejphar.2005.12.060_bib105","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1183\/09031936.94.07111973","article-title":"Bronchoprotection by salmeterol: cell stabilization or functional antagonism? Comparative effects on histamine- and AMP-induced bronchoconstriction","volume":"7","author":"Soler","year":"1994","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2005.12.060_bib106","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1067\/mai.2000.107396","article-title":"Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol","volume":"106","author":"Swystun","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib107","first-page":"993","article-title":"Stimulation of ciliary motility by \u03b23-adrenoceptor agonist in rabbit tracheal epithelium","volume":"41","author":"Takeyama","year":"1993","journal-title":"Kokyu To Junkan"},{"key":"10.1016\/j.ejphar.2005.12.060_bib108","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/0024-3205(93)90558-K","article-title":"Stimulation of ciliary motility mediated by atypical \u03b2-adrenoceptor in canine bronchial epithelium","volume":"53","author":"Tamaoki","year":"1993","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2005.12.060_bib109","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1164\/ajrccm.156.6.9703047","article-title":"Comparison of salmeterol and albuterol-induced bronchoprotection against adenosine monophosphate and histamine in mild asthma","volume":"156","author":"Taylor","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3109\/02770900009087308","article-title":"The influence of polymorphism at position 16 of the \u03b22-adrenoceptor on the development of tolerance to \u03b2-agonist","volume":"37","author":"Taylor","year":"2000","journal-title":"J. Asthma"},{"key":"10.1016\/j.ejphar.2005.12.060_bib111","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-2999(94)00771-X","article-title":"\u03b22- but not \u03b23-adrenoceptors mediate prejunctional inhibition of non-adrenergic non-cholinergic contraction of guinea pig main bronchi","volume":"275","author":"Ten Berge","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib112","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1471-4892(03)00047-X","article-title":"Long-acting \u03b22-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified","volume":"3","author":"Tennant","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib113","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1056-8719(99)00006-4","article-title":"Quantitation of tremor in response to \u03b2-adrenergic receptor stimulation in primates: relationship with hypokalemia","volume":"40","author":"Tesfamariam","year":"1998","journal-title":"J. Pharmacol. Toxicol. Meth."},{"key":"10.1016\/j.ejphar.2005.12.060_bib114","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-2999(91)90197-X","article-title":"Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage","volume":"193","author":"Tokuyama","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib115","first-page":"141s","article-title":"The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils","volume":"22","author":"Tool","year":"1996","journal-title":"Eur. Respir. J. Suppl."},{"key":"10.1016\/j.ejphar.2005.12.060_bib116","first-page":"1195","article-title":"Stimulation of beta adrenoceptors in human monocyte cell line (U937) up-regulates cAMP-specific phosphodiesterase","volume":"263","author":"Torphy","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib117","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2222.2004.01833.x","article-title":"Early and late bronchoconstriction, airway hyperreactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram","volume":"34","author":"Toward","year":"2004","journal-title":"Clin. Exp. Allergy"},{"issue":"Suppl. 3","key":"10.1016\/j.ejphar.2005.12.060_bib118","first-page":"S181","article-title":"Comparison of the inhibition of by salbutamol-NO and salbutamol of the bronchoconstriction by histamine in conscious guinea-pigs","volume":"50","author":"Toward","year":"2001","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejphar.2005.12.060_bib119","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1172\/JCI117838","article-title":"Genetic polymorphism of the \u03b22-adrenergic receptor in nocturnal and non-nocturnal asthma: evidence that Gly 16 correlates with the nocturnal phenotype","volume":"95","author":"Turki","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2005.12.060_bib120","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1365-2222.2004.02001.x","article-title":"\u03b22-adrenoceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children","volume":"34","author":"Turner","year":"2004","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2005.12.060_bib121","first-page":"52","article-title":"Role of catecholamines, release due to stress, on stimulation of heparin secretion by mast cells in rats","volume":"39","author":"Umarova","year":"1993","journal-title":"Fiziol. Z."},{"issue":"Suppl.","key":"10.1016\/j.ejphar.2005.12.060_bib122","first-page":"128","article-title":"Desensitization of smooth muscle and mast cell \u03b2-adrenoceptors in the airways of guinea-pig","volume":"135","author":"van der Heijden","year":"1984","journal-title":"Eur. J. Respir. Dis."},{"key":"10.1016\/j.ejphar.2005.12.060_bib124","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0954-6111(98)90140-8","article-title":"A comparison of the onset of action of salbutamol and formoterol in reversing methacholine-induced bronchoconstriction","volume":"92","author":"van Noord","year":"1998","journal-title":"Resp. Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib123","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1034\/j.1399-3003.2000.15e11.x","article-title":"Long-term treatment of chronic obstructive pulmonary disease with salmeterol and the additive effect of ipratropium","volume":"15","author":"van Noord","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2005.12.060_bib125","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0091-6749(05)80185-X","article-title":"Increased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitivity to salbutamol","volume":"86","author":"van Schayck","year":"1990","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib126","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/rmed.2001.1243","article-title":"Is the increase in bronchial responsiveness or FEV1 shortly after cessation of \u03b22-agonists reflecting a real deterioration of the disease in allergic asthmatic patients? A comparison between short-acting and long-acting \u03b22-agonists","volume":"96","author":"van Schayck","year":"2002","journal-title":"Respir. Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib127","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.2042-7158.1976.tb04649.x","article-title":"An in vitro method for the study of \u03b2-receptor mediated effects on slow contracting skeletal muscle","volume":"28","author":"Waldeck","year":"1976","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib128","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0022-3565(24)36358-X","article-title":"Kinetic studies of desensitization and resensitization of the relaxation response to beta-2 adrenoceptor agonists in isolated guinea pig trachea","volume":"280","author":"Wachsman","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2005.12.060_bib129","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0091-6749(82)90003-3","article-title":"Aerosolized terbutaline in asthmatics: development of subsensitivity with long-term administration","volume":"70","author":"Weber","year":"1982","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib130","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1164\/ajrccm.150.5.7952550","article-title":"Partial inhibition of the early and late asthmatic response by a single dose of salmeterol","volume":"150","author":"Weersink","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2005.12.060_bib131","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.immunol.17.1.255","article-title":"Immunologic basis of antigen-induced airway hyperresponsiveness","volume":"17","author":"Wills-Karp","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib132","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ppul.20049","article-title":"Symptoms, lung function, and \u03b22-adrenoceptor polymorphism in a birth cohort followed for 10 years","volume":"38","author":"Wilson","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib133","first-page":"H274","article-title":"Anaphylaxis-induced mesenteric vascular permeability, granulocyte adhesion, and platelet aggregates in rat","volume":"275","author":"Wither","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2005.12.060_bib134","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0090-6980(92)90111-6","article-title":"Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs","volume":"43","author":"Yamada","year":"1992","journal-title":"Prostaglandins"},{"key":"10.1016\/j.ejphar.2005.12.060_bib135","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1164\/ajrccm\/141.6.1446","article-title":"\u03b22-adrenergic receptors on eosinophils. Binding and functional studies","volume":"141","author":"Yukawa","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2005.12.060_bib136","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/10799898309041925","article-title":"Comparison of functional \u03b2-adrenoceptor heterogeneity in central and peripheral airway smooth muscle of guinea-pig and man","volume":"3","author":"Zaagsma","year":"1983","journal-title":"J. Recept. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905013920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299905013920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T19:51:43Z","timestamp":1736279503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299905013920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":140,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0014299905013920"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2005.12.060","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}