{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:11:47Z","timestamp":1760548307509,"version":"3.32.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.ejphar.2006.06.009","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T11:55:11Z","timestamp":1153828511000},"page":"82-90","source":"Crossref","is-referenced-by-count":16,"title":["Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine"],"prefix":"10.1016","volume":"544","author":[{"given":"Moon-Doo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Yong","family":"Eun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Hyun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2006.06.009_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)80728-X","article-title":"MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia","volume":"97","author":"Abott","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2006.06.009_bib2","first-page":"619","article-title":"Electrophysiologic effects of phenothiazines on canine cardiac fibers","volume":"184","author":"Arita","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.009_bib3","series-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","first-page":"485","article-title":"Drugs and the treatment of psychiatric disorders","author":"Balsessarini","year":"2001"},{"key":"10.1016\/j.ejphar.2006.06.009_bib4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.RES.83.5.560","article-title":"Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit","volume":"83","author":"Barry","year":"1998","journal-title":"Circ. Res."},{"year":"1989","series-title":"Disposition of Toxic Drugs and Chemicals in Man","author":"Baselt","key":"10.1016\/j.ejphar.2006.06.009_bib5"},{"key":"10.1016\/j.ejphar.2006.06.009_bib6","first-page":"15","article-title":"Drug-induced long QT syndrome: is HERG the root of all evil?","volume":"7","author":"Brown","year":"2000","journal-title":"Pharm. News"},{"key":"10.1016\/j.ejphar.2006.06.009_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00002018-200023030-00004","article-title":"Cardiovascular adverse effects of antipsychotic drugs","volume":"23","author":"Buckley","year":"2000","journal-title":"Drug Safety"},{"key":"10.1016\/j.ejphar.2006.06.009_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/15563659509017984","article-title":"Cardiotoxicity more common in thioridazine overdose than with other neuroleptics","volume":"33","author":"Buckley","year":"1995","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib9","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1124\/jpet.104.080853","article-title":"Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine","volume":"313","author":"Choi","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.009_bib10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0092-8674(95)90358-5","article-title":"A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome","volume":"80","author":"Curran","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2006.06.009_bib11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0002-8703(80)90153-2","article-title":"Cardiovascular effects of phenothiazines","volume":"100","author":"Elkayam","year":"1980","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejphar.2006.06.009_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0378-4347(00)83644-0","article-title":"Plasma prochlorperazine assay by high-performance liquid chromatography-electrochemistry","volume":"380","author":"Fowler","year":"1986","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.ejphar.2006.06.009_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0008-6363(00)00119-X","article-title":"The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology","volume":"47","author":"Haverkamp","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2006.06.009_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1113\/expphysiol.1996.sp003961","article-title":"Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea-pig isolated ventricular myocytes","volume":"81","author":"Heath","year":"1996","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib15","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jama.1965.03080250013003","article-title":"Sudden death during treatment with phenothiazine derivatives","volume":"192","author":"Hollister","year":"1965","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2006.06.009_bib16","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.CIR.81.2.686","article-title":"Class III antiarrhythmic agents have a lot of potential but a long way to go: reduced effectiveness and dangers of reverse use dependence","volume":"81","author":"Hondeghem","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2006.06.009_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2125.1991.tb03973.x","article-title":"Clinical pharmacology of prochlorperazine in healthy young males","volume":"32","author":"Isah","year":"1991","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib18","doi-asserted-by":"crossref","first-page":"H1891","DOI":"10.1152\/ajpheart.2000.278.6.H1891","article-title":"Inducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotype","volume":"278","author":"Jeron","year":"2000","journal-title":"Am. J. Physiol., Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib19","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1161\/01.CIR.94.10.2572","article-title":"Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide","volume":"94","author":"Kiehn","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2006.06.009_bib20","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/PL00005344","article-title":"Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels","volume":"359","author":"Kiehn","year":"1999","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/070674376901400307","article-title":"Prochlorperazine\u2014a review of the literature since 1956","volume":"14","author":"Lapierre","year":"1969","journal-title":"Can. Psychiatr. Assoc. J."},{"key":"10.1016\/j.ejphar.2006.06.009_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/009127008702700101","article-title":"Cardiac arrhythmia, sudden death, and psychoactive agents","volume":"27","author":"Lathers","year":"1987","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archpsyc.1968.01740020009002","article-title":"Sudden death and phenothiazines","volume":"18","author":"Leestma","year":"1968","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ejphar.2006.06.009_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1085\/jgp.115.3.229","article-title":"Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate","volume":"115","author":"Mitcheson","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2125.2000.00245.x","article-title":"Pharmacokinetic interactions between sildenafil and saquinavir\/ritonavir","volume":"50","author":"Muirhead","year":"2000","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib26","series-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","first-page":"1021","article-title":"Prokinetic agents, antiemetics, and agents used in irritable bowel syndrome","author":"Pasricha","year":"2001"},{"key":"10.1016\/j.ejphar.2006.06.009_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0002-8703(64)90247-9","article-title":"On sudden death","volume":"68","author":"Pruitt","year":"1964","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejphar.2006.06.009_bib28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0014-5793(97)01249-0","article-title":"A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG","volume":"417","author":"Rampe","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2006.06.009_bib29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0008-6363(02)00846-5","article-title":"Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development","volume":"58","author":"Redfern","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2006.06.009_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1085\/jgp.96.1.195","article-title":"Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents","volume":"96","author":"Sanguinetti","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2006.06.009_bib32","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1365-2125.1982.tb01427.x","article-title":"A simple and sensitive H.P.L.C. method for the assay of prochlorperazine in plasma","volume":"13","author":"Sankey","year":"1982","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib34","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.CIR.102.7.817","article-title":"Images in cardiovascular medicine. Labile repolarization from \u201ccell to bedside\u201d","volume":"102","author":"Shivkumar","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2006.06.009_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0014-5793(96)00355-9","article-title":"Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole","volume":"385","author":"Suessbrich","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2006.06.009_bib36","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0006-2952(98)00002-1","article-title":"Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications","volume":"55","author":"Taglialatela","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.009_bib37","doi-asserted-by":"crossref","first-page":"701","DOI":"10.7326\/0003-4819-122-9-199505010-00009","article-title":"Electrophysiologic mechanisms of the long QT interval syndromes and torsade de pointes","volume":"122","author":"Tan","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2006.06.009_bib38","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3565(24)29594-X","article-title":"High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872","volume":"297","author":"Thomas","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.009_bib39","first-page":"116","article-title":"Towards a drug concentration effect relationship for QT prolongation and torsades de pointes","volume":"5","author":"Webster","year":"2002","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1016\/j.ejphar.2006.06.009_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1113\/jphysiol.2001.013296","article-title":"A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?","volume":"540","author":"Weerapura","year":"2002","journal-title":"J. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906006248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906006248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T02:05:43Z","timestamp":1736474743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299906006248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":39,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0014299906006248"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.009","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}