{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T21:46:24Z","timestamp":1761428784175,"version":"3.44.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["B-18310044"],"award-info":[{"award-number":["B-18310044"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007807","name":"Japan Science Society","doi-asserted-by":"publisher","award":["16-278"],"award-info":[{"award-number":["16-278"]}],"id":[{"id":"10.13039\/501100007807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.ejphar.2006.06.010","type":"journal-article","created":{"date-parts":[[2006,6,12]],"date-time":"2006-06-12T12:47:11Z","timestamp":1150116431000},"page":"194-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Anti-androgenic activity of 3-methyl-4-nitrophenol in diesel exhaust particles"],"prefix":"10.1016","volume":"543","author":[{"given":"ChunMei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Taneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira K.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Taya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2006.06.010_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/(SICI)1099-1263(200001\/02)20:1<35::AID-JAT633>3.0.CO;2-8","article-title":"The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators","volume":"20","author":"Ashby","year":"2000","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.chemosphere.2004.11.048","article-title":"Wet deposition of pesticides and nitrophenols at two sites in Denmark: measurements and contributions from regional sources","volume":"59","author":"Asman","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejphar.2006.06.010_bib3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1095\/biolreprod.103.024810","article-title":"Estrogenic activities of nitrophenols in diesel exhaust particles","volume":"70","author":"Furuta","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2006.06.010_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1385\/ENDO:27:1:033","article-title":"Immunohistological study for estrogenic activities of nitrophenols in diesel exhaust particles","volume":"27","author":"Furuta","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.ejphar.2006.06.010_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/01485017808988345","article-title":"Serum LH and FSH following passive immunization against circulating testosterone in the intact male rat and in orchidectomized rats bearing subcutaneous silastic implants of testosterone","volume":"1","author":"Gay","year":"1978","journal-title":"Arch. Androl."},{"key":"10.1016\/j.ejphar.2006.06.010_bib6","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1128\/AEM.66.4.1737-1740.2000","article-title":"Involvement of two plasmids in fenitrothion degradation by Burkholderia sp. strain NF100","volume":"66","author":"Hayatsu","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3181\/00379727-83-20301","article-title":"Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method","volume":"83","author":"Hershberger","year":"1953","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2006.06.010_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2131\/jts.18.111","article-title":"Effects of procymidone on reproductive organs and serum gonadotropins in male rats","volume":"18","author":"Hosokawa","year":"1993","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2006.06.010_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/carcin\/18.1.185","article-title":"Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles","volume":"18","author":"Ichinose","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2006.06.010_bib10","series-title":"The Research Report on the Total Amount of Emission and Automobile Exhaust Source Unit\u2014The NOX According to Object Automobile in the Usual Transit","first-page":"200","author":"Japan Environmetal Agency","year":"1998"},{"key":"10.1016\/j.ejphar.2006.06.010_bib11","first-page":"E744","article-title":"Inhibin is an important factor in the regulation of FSH secretion in the adult male hamster","volume":"278","author":"Kishi","year":"2000","journal-title":"Am. J. Physiol: Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2006.06.010_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/toxsci\/kfg230","article-title":"Antiandrogenic activities of diesel exhaust particle extracts in PC3\/AR human prostate carcinoma cells","volume":"76","author":"Kizu","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2006.06.010_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0083-6729(08)61151-6","article-title":"Molecular mechanisms of androgen action","volume":"49","author":"Lindzey","year":"1994","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.ejphar.2006.06.010_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.pa.27.040187.001431","article-title":"Health effects of exposure to diesel exhaust particles","volume":"27","author":"McClellan","year":"1987","journal-title":"Annu. Rev. Phuman Androgen Receptormacol. Toxicol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/enrs.1998.3870","article-title":"Ah receptor and estrogen receptor-dependent modulation of gene expression by extracts of diesel exhaust particles","volume":"79","author":"Meek","year":"1998","journal-title":"Environ. Res."},{"key":"10.1016\/j.ejphar.2006.06.010_bib16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000023935","article-title":"Diesel exhaust inhalation enhances airway hyperresponsiveness in mice","volume":"116","author":"Miyabara","year":"1998","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1248\/bpb.26.394","article-title":"Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds","volume":"26","author":"Mori","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2006.06.010_bib18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0091-6749(86)90355-6","article-title":"Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice","volume":"77","author":"Muranaka","year":"1986","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/toxs.1998.2550","article-title":"An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs)","volume":"46","author":"O'Connor","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2006.06.010_bib20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tox.2003.10.011","article-title":"Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under different engine loads and speeds","volume":"195","author":"Okamura","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2006.06.010_bib21","first-page":"271","article-title":"Androgen receptor defects: historical, clinical, and molecular perspectives","volume":"16","author":"Quigley","year":"1995","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2006.06.010_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0022-4731(80)90264-2","article-title":"Steroid hormone receptors and pharmacology","volume":"12","author":"Raynaud","year":"1980","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.ejphar.2006.06.010_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0891-5849(93)90507-Q","article-title":"Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse","volume":"14","author":"Sagai","year":"1993","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2006.06.010_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1677\/joe.0.1580327","article-title":"Several environmental oestrogens are also anti-androgens","volume":"158","author":"Sohoni","year":"1998","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0091-6749(87)80161-6","article-title":"Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice","volume":"79","author":"Takafuji","year":"1987","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2006.06.010_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/toxsci\/60.1.56","article-title":"Androgen receptor antagonism by the organophosphate insecticide fenitrothion","volume":"60","author":"Tamura","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2006.06.010_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-483X(01)00516-9","article-title":"Estrogenic and anti-estrogenic activities of two types of diesel exhaust particles","volume":"170","author":"Taneda","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2006.06.010_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1248\/jhs.50.133","article-title":"Investigation of vasodilatory substances in diesel exhaust particles (DEP): isolation and identification on nitrophenol derivatives","volume":"50","author":"Taneda","year":"2004","journal-title":"J. Health Sci."},{"key":"10.1016\/j.ejphar.2006.06.010_bib29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1248\/bpb.27.835","article-title":"Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP)","volume":"27","author":"Taneda","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2006.06.010_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1262\/jrd1977.31.186","article-title":"Radioimmunoassay for progesterone, testosterone, and estradiol-17\u03b2 using 125I-iodohistamine radioligands","volume":"31","author":"Taya","year":"1985","journal-title":"Jpn. J. Anim. Reprod."},{"key":"10.1016\/j.ejphar.2006.06.010_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/15287390151126441","article-title":"Diesel exhaust (DE) affects the regulation of testicular function in male Fischer 344 rats","volume":"63","author":"Tsukue","year":"2001","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.ejphar.2006.06.010_bib32","first-page":"5","article-title":"Air pollution in the world's megacities","volume":"36","author":"United Nations Environment Program","year":"1994","journal-title":"Environment"},{"key":"10.1016\/j.ejphar.2006.06.010_bib33","first-page":"71541","article-title":"Endocrine disruptor screening program; proposed statement of policy","volume":"63","author":"US EPA","year":"1998","journal-title":"Fed. Regist."},{"key":"10.1016\/j.ejphar.2006.06.010_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0022-4731(81)90297-1","article-title":"Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens","volume":"15","author":"Wakeling","year":"1981","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.ejphar.2006.06.010_bib35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1289\/ehp.99107539","article-title":"Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats","volume":"107","author":"Watanabe","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ejphar.2006.06.010_bib36","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/toxsci\/53.2.289","article-title":"Comparative evaluation of a 5-day Hershberger assay utilizing mature male rats and a pubertal male assay for detection of flutamide's antiandrogenic activity","volume":"53","author":"Yamada","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ejphar.2006.06.010_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0300-483X(02)00445-6","article-title":"Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals","volume":"183","author":"Yamasaki","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2006.06.010_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tox.2003.09.012","article-title":"Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals","volume":"195","author":"Yamasaki","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2006.06.010_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1365-2605.1999.00185.x","article-title":"Exposure to diesel exhaust affects the male reproductive system of mice","volume":"22","author":"Yoshida","year":"1999","journal-title":"Int. J. Androl."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990600625X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990600625X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:07:28Z","timestamp":1757974048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429990600625X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":39,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S001429990600625X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.010","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-androgenic activity of 3-methyl-4-nitrophenol in diesel exhaust particles","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}