{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:24:01Z","timestamp":1769005441126,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.ejphar.2006.06.053","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T09:27:02Z","timestamp":1151746022000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Suppression of ischemia\/reperfusion liver injury by histamine H4 receptor stimulation in rats"],"prefix":"10.1016","volume":"544","author":[{"given":"Naoto","family":"Adachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Motoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nishibori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuru","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2006.06.053_bib1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s001340000690","article-title":"Prostaglandin E1 improves hepatic encephalopathy produced by ischaemia\u2013reperfusion liver injury in rats","volume":"26","author":"Adachi","year":"2000","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.ejphar.2006.06.053_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cytogfr.2004.06.003","article-title":"Histamine\u2013cytokine connection in immunity and hematopoiesis","volume":"15","author":"Dy","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ejphar.2006.06.053_bib3","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.4049\/jimmunol.161.5.2586","article-title":"Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors","volume":"161","author":"Elenkov","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2006.06.053_bib4","first-page":"1174","article-title":"Histamine H4 receptor antagonists: the new antihistamines?","volume":"5","author":"Fung-Leung","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.ejphar.2006.06.053_bib5","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.4049\/jimmunol.174.9.5224","article-title":"Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells","volume":"174","author":"Gutzmer","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2006.06.053_bib6","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1182\/blood.V90.5.1920","article-title":"Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype","volume":"90","author":"Hilkens","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2006.06.053_bib7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0022-5347(25)00198-3","article-title":"Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats","volume":"241","author":"Hirasawa","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.053_bib8","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1124\/jpet.102.046581","article-title":"Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells","volume":"305","author":"Hofstra","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.053_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/A:1026032611643","article-title":"Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model","volume":"27","author":"Hornyak","year":"2003","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2006.06.053_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/00007890-198911000-00007","article-title":"The beneficial effect of cyclosporine on liver ischemia in rats","volume":"48","author":"Kawano","year":"1989","journal-title":"Transplantation"},{"key":"10.1016\/j.ejphar.2006.06.053_bib11","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1124\/jpet.105.087965","article-title":"Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist","volume":"314","author":"Lim","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.053_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.bjp.0705729","article-title":"Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation","volume":"142","author":"Ling","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.053_bib13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0026-895X(24)12230-4","article-title":"Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow","volume":"59","author":"Liu","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.053_bib14","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0022-3565(24)38851-2","article-title":"Cloning and characterization of a novel human histamine receptor","volume":"296","author":"Morse","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.053_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol. Today"},{"key":"10.1016\/j.ejphar.2006.06.053_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0026-895X(24)12231-6","article-title":"Discovery of a novel member of the histamine receptor family","volume":"59","author":"Nguyen","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.06.053_bib17","doi-asserted-by":"crossref","first-page":"36781","DOI":"10.1074\/jbc.M006480200","article-title":"Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes","volume":"275","author":"Oda","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2006.06.053_bib18","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1124\/jpet.301.3.1157","article-title":"Ranitidine reduces ischemia\/reperfusion-induced liver injury in rats by inhibiting neutrophil activation","volume":"301","author":"Okajima","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.053_bib19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1567-5769(02)00235-7","article-title":"Effects of histamine on Th1\/Th2 cytokine balance","volume":"3","author":"Packard","year":"2003","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2006.06.053_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0024-3205(90)90623-Y","article-title":"FK 506 ameliorates the hepatic injury associated with ischemia","volume":"47","author":"Sakr","year":"1990","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2006.06.053_bib21","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1124\/jpet.103.061754","article-title":"A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties","volume":"309","author":"Thurmond","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.06.053_bib22","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1053\/j.gastro.2004.06.020","article-title":"Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation","volume":"127","author":"Yokoyama","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2006.06.053_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0026-895X(24)12232-8","article-title":"Cloning, expression, and pharmacological characterization of a novel human histamine receptor","volume":"59","author":"Zhu","year":"2001","journal-title":"Mol. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906006509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906006509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:07:35Z","timestamp":1757974055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299906006509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":23,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0014299906006509"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.053","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of ischemia\/reperfusion liver injury by histamine H4 receptor stimulation in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}