{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:34:43Z","timestamp":1762144483917,"version":"3.32.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.ejphar.2006.07.038","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T15:50:10Z","timestamp":1154447410000},"page":"28-35","source":"Crossref","is-referenced-by-count":23,"title":["Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells"],"prefix":"10.1016","volume":"546","author":[{"given":"Francis Fu Yuen","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Wang","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiu Wa","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Hok Keung","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2006.07.038_bib1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1399-3089.2001.00176.x","article-title":"Morphometric analysis of miniature swine hearts as potential human xenografts","volume":"8","author":"Allan","year":"2001","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.ejphar.2006.07.038_bib2","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1093\/jn\/128.12.2324","article-title":"Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta","volume":"128","author":"Andriambeloson","year":"1998","journal-title":"J. Nutr."},{"key":"10.1016\/j.ejphar.2006.07.038_bib4","first-page":"1038","article-title":"Modulation by homocysteine of the iberiotoxin-sensitive BKCa channels of pig coronary artery smooth muscle cells","volume":"38","author":"Au","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-2999(03)01691-1","article-title":"Mechanisms responsible for the in vitro relaxation of ligustrazine on porcine left anterior descending coronary artery","volume":"468","author":"Au","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0940-2993(99)80066-9","article-title":"Inhibitory effect of caffeic acid analogues isolated from Salviae miltiorrhizae Radix against 1,1-diphenyl-2-picrylhydrazyl radical","volume":"51","author":"Chen","year":"1999","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(01)01533-3","article-title":"Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery","volume":"434","author":"Choy","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1085\/jgp.112.4.485","article-title":"Mechanism of maxi-K channel activation by dehydrosoyasaponin-I","volume":"112","author":"Giangiacomo","year":"1998","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib8","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1124\/mol.105.016170","article-title":"Electrophysiological characterization of benzofuroindole-induced potentiation of large-conductance Ca2+-activated K+ channels","volume":"69","author":"Ha","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.ejphar.2006.07.038_bib10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1124\/jpet.105.094656","article-title":"Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries","volume":"316","author":"Hatanada","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.07.038_bib11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s004240050563","article-title":"Enhancement of Ca2+-dependent outward current in sheep bladder myocytes by Evans blue dye","volume":"435","author":"Hollywood","year":"1998","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.ejphar.2006.07.038_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0306-3623(93)90176-X","article-title":"Endothelium-dependent vasodilator effects of the extract from Salviae Miltiorrhizae radix. A study on the identification of lithospermic acid B in the extracts","volume":"24","author":"Kamata","year":"1993","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0306-3623(94)90011-6","article-title":"Hypotensive effects of lithospermic acid B isolated from the extracts of Salviae miltiorrhizae Radix in the rat","volume":"25","author":"Kamata","year":"1994","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib14","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/ptr.1250","article-title":"Inhibition of angiotensin converting enzyme by lithospermic acid B isolated from Radix Salviae miltiorrhiza Bunge","volume":"17","author":"Kang","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2006.07.038_bib15","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.lfs.2004.02.034","article-title":"Lithospermic acid B isolated from Salviae miltiorrhiza ameliorates ischaemia\/reperfusion-induced renal injury in rats","volume":"75","author":"Kang","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2006.07.038_bib16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1248\/cpb.46.500","article-title":"Comparative study of seventeen Salvia plants: aldose reductase inhibitory activity of water and MeOH extracts and liquid chromatography-mass spectrometry (LC-MS) analysis of water extracts","volume":"46","author":"Kasimu","year":"1998","journal-title":"Chem. Pharmacol. Bull."},{"key":"10.1016\/j.ejphar.2006.07.038_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0014-2999(98)00768-7","article-title":"Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar\u2013Kyoto rats","volume":"365","author":"Kwan","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.fjc.0000175439.94906.e9","article-title":"Mechanisms of the dilator action of Danshen (Salviae miltiorrhiza) on rat isolated femoral artery","volume":"46","author":"Lam","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jep.2005.09.033","article-title":"Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joints","volume":"104","author":"Lam","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/01.fjc.0000197540.12685.ce","article-title":"Pharmacological evidence for calcium channel inhibition by Danshen (Salvia miltiorrhiza) on rat isolated femoral artery","volume":"47","author":"Lam","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1142\/S0192415X86000053","article-title":"Studies on cardiovascular actions of Salvia miltiorrhiza","volume":"14","author":"Lei","year":"1986","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejphar.2006.07.038_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-2952(92)90271-J","article-title":"Protective action of seven natural phenolic compounds against peroxidative damage to bio-membranes","volume":"43","author":"Liu","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0031-9422(01)00415-0","article-title":"Polyphenolics of Salvia\u2014a review","volume":"59","author":"Lu","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejphar.2006.07.038_bib24","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1113\/jphysiol.1990.sp018192","article-title":"Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes","volume":"427","author":"Matsuda","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib25","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1073\/pnas.0600907103","article-title":"Defining the BK channel domains required for \u03b21-subunit modulation","volume":"103","author":"Morrow","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2006.07.038_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00877627","article-title":"Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels","volume":"7","author":"Nelson","year":"1993","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ejphar.2006.07.038_bib27","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0006-3495(94)80712-X","article-title":"Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids","volume":"67","author":"Ottolia","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejphar.2006.07.038_bib28","first-page":"149","article-title":"Calcium entry blocking properties of tanshinone II-A sulphonate, an active principal of the antianginal extract, Dan Shen","volume":"75","author":"Patmore","year":"1982","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00276-000-0047-x","article-title":"Lymphatic drainage of heart and lungs: comparison between pig and man","volume":"22","author":"Riquet","year":"2000","journal-title":"Surg. Radiol. Anat."},{"key":"10.1016\/j.ejphar.2006.07.038_bib30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.lfs.2005.05.063","article-title":"Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro pulmonary artery relaxation of rat","volume":"78","author":"Seto","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2006.07.038_bib31","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1124\/mol.104.002642","article-title":"Cloning, up-regulation, and mitogenic role of porcine P2Y2 receptor in coronary artery smooth muscle cells","volume":"66","author":"Shen","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib32","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1039\/p19940003349","article-title":"Maxikdiol: a novel dihydroxyisoprimane as an agonist of maxi-K channels","volume":"1","author":"Singh","year":"1994","journal-title":"J. Chem. Soc. (Perkin)"},{"key":"10.1016\/j.ejphar.2006.07.038_bib33","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1211\/0022357021891","article-title":"Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza","volume":"55","author":"Soung","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/sj.bjp.0705957","article-title":"Pharmacological evidence for a key role of voltage-gated K+ channels in the function of rat aortic smooth muscle cells","volume":"143","author":"Tammaro","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib35","series-title":"Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine","first-page":"891","author":"Tang","year":"1992"},{"key":"10.1016\/j.ejphar.2006.07.038_bib36","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00005344-200211000-00008","article-title":"Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features","volume":"40","author":"Taubert","year":"2002","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib37","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1016\/j.lfs.2005.11.024","article-title":"Selective modulation of l-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes","volume":"78","author":"Wang","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2006.07.038_bib39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/01.ATV.18.3.481","article-title":"Increase of vitamin E content in LDL and reduction of atherosclerosis in cholesterol-fed rabbits by a water-soluble antioxidant-rich fraction of Salvia miltiorrhiza","volume":"18","author":"Wu","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib38","first-page":"855","article-title":"Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B","volume":"21","author":"Wu","year":"2000","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2006.07.038_bib40","first-page":"362","article-title":"Modulation of three types of K+ currents in canine coronary artery smooth muscle cells by NS-004, or 1-(2\u2032-hydroxy-5\u2032-chlorophenyl)-5-trifluoromethyl-2(3H) benzimidazolone","volume":"271","author":"Xu","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.07.038_bib41","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0022-3565(24)35081-5","article-title":"Activation of Ca2+-dependent K+ current by nordihydroguaiaretic acid in porcine coronary arterial smooth muscle cells","volume":"291","author":"Yamamura","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2006.07.038_bib42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0940-2993(11)80344-1","article-title":"Confirmation that magnesium lithospermic acid B has a hydroxyl radical-scavenging action","volume":"47","author":"Yokozawa","year":"1995","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.bjp.0705969","article-title":"A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes","volume":"143","author":"Yoon","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.07.038_bib44","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/rcm.2332","article-title":"Identification of phenolic constituents in Radix Salvia miltiorrhizae by liquid chromatography\/electrospray ionization mass spectrometry","volume":"20","author":"Zeng","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.ejphar.2006.07.038_bib45","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"Eur. Mol. Biol. Organ J."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906007825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906007825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T08:14:12Z","timestamp":1736496852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299906007825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":45,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0014299906007825"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.07.038","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}