{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:22:10Z","timestamp":1773242530991,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.ejphar.2006.09.006","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T14:30:32Z","timestamp":1158676232000},"page":"151-158","source":"Crossref","is-referenced-by-count":14,"title":["Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism"],"prefix":"10.1016","volume":"552","author":[{"given":"Anna M.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenal","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel F.","family":"Tyndale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2006.09.006_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00008571-200004000-00005","article-title":"Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes","volume":"10","author":"Abdel-Rahman","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.ejphar.2006.09.006_bib2","first-page":"483","article-title":"Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver","volume":"26","author":"Amato","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib3","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/0006-2952(87)90572-7","article-title":"Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers","volume":"36","author":"Bock","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.pharmtox.44.101802.121704","article-title":"Oxidative stress, toxicology, and pharmacology of CYP2E1","volume":"44","author":"Caro","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/jbt.20103","article-title":"Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT-PCR","volume":"19","author":"Caron","year":"2005","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib6","series-title":"Cloning of Rhesus Monkey Cytochrome P450 2E1 (CYP2E1)","author":"Carr","year":"2004"},{"key":"10.1016\/j.ejphar.2006.09.006_bib7","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/0024-3205(96)00132-4","article-title":"Effects of cytochrome P450 2E1 modulators on the pharmacokinetics of chlorzoxazone and 6-hydroxychlorzoxazone in rats","volume":"58","author":"Chen","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2006.09.006_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1099-081X(199704)18:3<213::AID-BDD15>3.0.CO;2-0","article-title":"Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species","volume":"18","author":"Court","year":"1997","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib9","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jps.2600720905","article-title":"Pharmacokinetics of chlorzoxazone in humans","volume":"72","author":"Desiraju","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2006.09.006_bib10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0090-9556(24)15291-9","article-title":"Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice","volume":"27","author":"Doerr-Stevens","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0006-291X(88)90539-6","article-title":"Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures","volume":"150","author":"Eliasson","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2006.09.006_bib12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0091-3057(90)90417-G","article-title":"Voluntary consumption of beverage alcohol by vervet monkeys: population screening, descriptive behavior and biochemical measures","volume":"36","author":"Ervin","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2006.09.006_bib13","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1124\/dmd.30.11.1206","article-title":"In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs","volume":"30","author":"Graham","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/tx00020a008","article-title":"Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects","volume":"4","author":"Guengerich","year":"1991","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib15","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/sj.bjp.0705146","article-title":"Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics","volume":"138","author":"Howard","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0006-291X(88)80010-X","article-title":"Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver","volume":"157","author":"Ingelman-Sundberg","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2006.09.006_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neuropharm.2005.11.001","article-title":"Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine","volume":"50","author":"Joshi","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2006.09.006_bib18","first-page":"353","article-title":"Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment","volume":"29","author":"Kim","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0006-2952(01)00843-7","article-title":"Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat","volume":"63","author":"Kobayashi","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0167-4781(92)90113-E","article-title":"Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450","volume":"1171","author":"Komori","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2006.09.006_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.neuropharm.2005.10.003","article-title":"CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment","volume":"50","author":"Lee","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2006.09.006_bib22","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1124\/dmd.106.010363","article-title":"In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys; induction by chronic nicotine treatment","volume":"34","author":"Lee","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib23","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1530-0277.1999.tb04217.x","article-title":"Microsomal ethanol-oxidizing system (MEOS): the first 30\u00a0years (1968\u20131998)\u2014a review","volume":"23","author":"Lieber","year":"1999","journal-title":"Alcohol., Clin. Exp. Res."},{"key":"10.1016\/j.ejphar.2006.09.006_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00008571-199906000-00013","article-title":"Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans","volume":"9","author":"Lucas","year":"1999","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.ejphar.2006.09.006_bib25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/dmd.31.4.421","article-title":"Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes","volume":"31","author":"Madan","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib26","unstructured":"Martin, R.F., Bowden, D.M., 2000. Primate brain maps: Structure of the macaque brain: A laboratory guide with original brain sections, printed atlas and electronic templates for data and schematics\/Richard F. Martin and Douglas M. Bowden; software by John Wu, Mark F. Dubach and Joan E. Robertson. In: Elsevier, Oxford."},{"key":"10.1016\/j.ejphar.2006.09.006_bib27","doi-asserted-by":"crossref","first-page":"12A","DOI":"10.1111\/j.1530-0277.1996.tb01719.x","article-title":"Evidence that cytochrome P-4502E1 contributes to ethanol elimination at low doses: effects of diallyl sulfide and 4-methyl pyrazole on ethanol elimination in the perfused rat liver","volume":"20","author":"Matsumoto","year":"1996","journal-title":"Alcohol., Clin. Exp. Res."},{"key":"10.1016\/j.ejphar.2006.09.006_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0378-4274(99)00058-2","article-title":"Evaluation of rat hepatic 2E1 activity in function of age, sex and inducers: choice of an experimental model capable of testing the hepatotoxicity of low molecular weight compounds","volume":"106","author":"Morel","year":"1999","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2006.09.006_bib29","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3109\/00498259609050257","article-title":"Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats","volume":"26","author":"Nebbia","year":"1996","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejphar.2006.09.006_bib30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-5793(99)01361-7","article-title":"A soluble NH(2)-terminally truncated catalytically active form of rat cytochrome P450 2E1 targeted to liver mitochondria(1)","volume":"460","author":"Neve","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2006.09.006_bib31","first-page":"298","article-title":"Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1","volume":"19","author":"Olson","year":"1991","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2006.09.006_bib32","first-page":"294","article-title":"Non-uniformity of blood ethanol elimination: its exaggeration after chronic consumption","volume":"10","author":"Salaspuro","year":"1978","journal-title":"Ann. Clin. Res."},{"key":"10.1016\/j.ejphar.2006.09.006_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1124\/mol.63.1.96","article-title":"Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration","volume":"63","author":"Schoedel","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2006.09.006_bib34","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/carcin\/18.4.801","article-title":"Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1","volume":"18","author":"Shu","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2006.09.006_bib35","series-title":"A Sterotaxic Atlas of the Monkey Brain (Macaca mulatta)","author":"Snider","year":"1961"},{"key":"10.1016\/j.ejphar.2006.09.006_bib36","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0090-9556(24)15243-9","article-title":"Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan","volume":"27","author":"Tyndale","year":"1999","journal-title":"Drug Metab. Dispos."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906010041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299906010041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T22:41:11Z","timestamp":1736548871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299906010041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":36,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0014299906010041"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2006.09.006","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}