{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:24Z","timestamp":1786988124035,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.ejphar.2007.01.078","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T07:05:52Z","timestamp":1171004752000},"page":"233-239","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacological characterization of a chronic pruritus model induced by multiple application of 2,4,6-trinitrochlorobenzene in NC mice"],"prefix":"10.1016","volume":"563","author":[{"given":"Hirotaka","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Nose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 70","key":"10.1016\/j.ejphar.2007.01.078_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2133.2004.06269.x","article-title":"The role of topical calcineurin inhibitors in atopic dermatitis","volume":"151","author":"Alomar","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib2","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1097\/00001756-200111160-00020","article-title":"Histamine-induced itch converts into pain in neuropathic hyperalgesia","volume":"12","author":"Baron","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2007.01.078_bib3","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.4049\/jimmunol.146.7.2374","article-title":"FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human Fc epsilon RI+ cells","volume":"146","author":"De Paulis","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib4","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1248\/bpb.27.1376","article-title":"Establishment of allergic dermatitis in NC\/Nga mice as a model for severe atopic dermatitis","volume":"27","author":"Gao","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2007.01.078_bib5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2460\/ajvr.1997.58.03.293","article-title":"Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells","volume":"58","author":"Garc\u00eda","year":"1997","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ejphar.2007.01.078_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2567.2001.01288.x","article-title":"Topical tacrolimus and cyclosporin A differentially inhibit early and late effector phases of cutaneous delayed-type and immunoglobulin E hypersensitivity","volume":"104","author":"Geba","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2007.01.078_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000211009","article-title":"Peripheral and central mediators of itch","volume":"5","author":"H\u00e4germark","year":"1992","journal-title":"Skin Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/jn.1991.66.1.307","article-title":"Discharge patterns of human C-fibers induced by itching and burning stimuli","volume":"66","author":"Handwerker","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1365-2133.2000.03241.x","article-title":"Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy","volume":"142","author":"Harper","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/WNL.62.2.212","article-title":"Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch","volume":"62","author":"Ikoma","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2007.01.078_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000056338","article-title":"Scratching behavior in various strains of mice","volume":"14","author":"Inagaki","year":"2001","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-2999(02)01933-7","article-title":"Involvement of unique mechanisms in the induction of scratching behavior in BALB\/c mice by compound 48\/80","volume":"448","author":"Inagaki","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000069755","article-title":"Evaluation and characterization of mouse scratching behavior by a new apparatus, MicroAct","volume":"16","author":"Inagaki","year":"2003","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000237268","article-title":"Effect of mast cell modulators on IgE-mediated murine biphasic cutaneous reactions","volume":"109","author":"Katayama","year":"1996","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00001756-200103260-00020","article-title":"Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats","volume":"12","author":"Kawabata","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2007.01.078_bib16","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1001\/archderm.135.12.1522","article-title":"An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis","volume":"135","author":"Klein","year":"1999","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib17","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1254\/jjp.84.462","article-title":"Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice","volume":"84","author":"Maekawa","year":"2000","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/1523-1747.ep12874474","article-title":"Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region","volume":"94","author":"Magerl","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1398-9995.2003.23790.x","article-title":"A mouse model of the atopic eczema\/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae","volume":"58","author":"Matsuoka","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2007.01.078_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1398-9995.1994.tb02657.x","article-title":"In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin","volume":"49","author":"Okayama","year":"1994","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2007.01.078_bib22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1001\/archderm.136.8.999","article-title":"Safety and efficacy of 1\u00a0year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group","volume":"136","author":"Reitamo","year":"2000","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib23","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1046\/j.1365-2133.2000.03535.x","article-title":"Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study","volume":"142","author":"Rukwied","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000049520","article-title":"Atopic dermatitis-like skin lesions induced by topical application of mite antigens in NC\/Nga mice","volume":"126","author":"Sasakawa","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0192-0561(99)00076-4","article-title":"FK506 inhibition of histamine release and cytokine production by mast cells and basophils","volume":"22","author":"Sengoku","year":"2000","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/08990229109144750","article-title":"Psychophysical studies of the itch sensation and itchy skin (\u201calloknesis\u201d) produced by intracutaneous injection of histamine","volume":"8","author":"Simone","year":"1991","journal-title":"Somatosens. Motor Res."},{"key":"10.1016\/j.ejphar.2007.01.078_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2007.01.078_bib27","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003","article-title":"Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin","volume":"23","author":"Steinhoff","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2007.01.078_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00288-X","article-title":"Effects of histamine H1 receptor antagonists on compound 48\/80-induced scratching behavior in mice","volume":"351","author":"Sugimoto","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s004030050167","article-title":"Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis","volume":"289","author":"Sugiura","year":"1997","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.ejphar.2007.01.078_bib31","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.4049\/jimmunol.148.11.3446","article-title":"Stimulation of mouse connective tissue-type mast cells by hemopoietic stem cell factor, a ligand for the c-kit receptor","volume":"148","author":"Takagi","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0091-6749(92)90134-N","article-title":"Increased number of immunoreactive nerve fibers in atopic dermatitis","volume":"90","author":"Tobin","year":"1992","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1254\/jjp.74.77","article-title":"Intracisternal injection of opioids induces itch-associated response through mu-opioid receptors in mice","volume":"74","author":"Tohda","year":"1997","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2133.2002.04803.x","article-title":"Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis","volume":"147","author":"Toyoda","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1182\/blood.V75.2.421.bloodjournal752421","article-title":"Effects of interleukin-3 and interleukin-4 on the development of \u201cconnective tissue-type\u201d mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3","volume":"75","author":"Tsuji","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2007.01.078_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0925-5710(95)00351-R","article-title":"Synergistic action of interleukin-10 (IL-10) with IL-3, IL-4 and stem cell factor on colony formation from murine mast cells in culture","volume":"61","author":"Tsuji","year":"1995","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejphar.2005.11.021","article-title":"Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice","volume":"530","author":"Ui","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s004280050179","article-title":"Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study","volume":"432","author":"Urashima","year":"1998","journal-title":"Virchows Arch."},{"key":"10.1016\/j.ejphar.2007.01.078_bib39","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI7613","article-title":"Overproduction of Th2-specific chemokines in NC\/Nga mice exhibiting atopic dermatitis-like lesions","volume":"104","author":"Vestergaard","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2007.01.078_bib40","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1346-8138.1999.tb02090.x","article-title":"Itch and atopic dermatitis: an overview","volume":"26","author":"Wahlgren","year":"1999","journal-title":"J. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib41","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4049\/jimmunol.140.7.2356","article-title":"Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate","volume":"140","author":"Wershil","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib42","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1254\/jjp.78.337","article-title":"Itch-associated response and antinociception induced by intracisternal endomorphins in mice","volume":"78","author":"Yamaguchi","year":"1998","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-0102(99)00070-X","article-title":"Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice","volume":"35","author":"Yamaguchi","year":"1999","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2007.01.078_bib44","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.0906-6705.2005.00304.x","article-title":"Dermal mast cells play a central role in the incidence of scratching behavior in mice induced by multiple application of the hapten, 2,4,6-trinitrochlorobenzene","volume":"14","author":"Yamashita","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ejphar.2007.01.078_bib45","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1172\/JCI114295","article-title":"Substance P-induced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent","volume":"84","author":"Yano","year":"1989","journal-title":"J. Clin. Invest."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907001422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907001422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T16:49:34Z","timestamp":1707583774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907001422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":45,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0014299907001422"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.01.078","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}