{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:58:29Z","timestamp":1790985509435,"version":"4.1.0"},"reference-count":149,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.ejphar.2007.02.018","type":"journal-article","created":{"date-parts":[[2007,2,18]],"date-time":"2007-02-18T11:54:49Z","timestamp":1171799689000},"page":"1-17","source":"Crossref","is-referenced-by-count":96,"title":["Cancer relapse under chemotherapy: Why TLR2\/4 receptor agonists can help"],"prefix":"10.1016","volume":"563","author":[{"given":"Ricardo P.","family":"Garay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Viens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Normier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bardou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Jeannin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Chiavaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2007.02.018_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0163-7258(03)00056-1","article-title":"Immune responses in cancer","volume":"99","author":"Adam","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2007.02.018_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.coi.2005.01.004","article-title":"Migration of dendritic cell based cancer vaccines: in vivo veritas?","volume":"17","author":"Adema","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/318665a0","article-title":"Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon","volume":"318","author":"Aggarwal","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2007.02.018_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/clon.2001.0050","article-title":"Repeated AFP surge: an unusual and potentially misleading tumor marker phenomenon","volume":"14","author":"Al-Karim","year":"2002","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/jnci\/52.1.95","article-title":"Biologically active components from mycobacterial cell walls. I. Isolation and composition of cell wall skeleton and component P3","volume":"52","author":"Azuma","year":"1974","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejphar.2007.02.018_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbamcr.2004.12.005","article-title":"Bcl-xL\/Bax ratio is altered by IFN-gamma in TNF-alpha but not in TRAIL-induced apoptosis in colon cancer cell line","volume":"1745","author":"Baillat","year":"2005","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00062752-200105000-00008","article-title":"Hematopoietic growth factors in the older cancer patient","volume":"8","author":"Balducci","year":"2001","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib8","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1006\/gyno.2002.6696","article-title":"Discussion: immunological therapeutics in ovarian cancer","volume":"88","author":"Balkwill","year":"2003","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2007.02.018_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(03)00160-9","article-title":"Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2","volume":"130","author":"Becker","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib11","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/jnci\/84.17.1341","article-title":"Thymopentin in Sezary syndrome","volume":"84","author":"Bernengo","year":"1992","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejphar.2007.02.018_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1006\/bcmd.2001.0441","article-title":"Synergy between TLR2 and TLR4: a safety mechanism","volume":"27","author":"Beutler","year":"2001","journal-title":"Blood Cells Mol. Diseases"},{"key":"10.1016\/j.ejphar.2007.02.018_bib13","first-page":"488","article-title":"Recent knowledge on BCG's mechanism of action in the treatment of superficial bladder cancer","volume":"26","author":"B\u00f6hle","year":"2000","journal-title":"Brazilain J. Urol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib14","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1046\/j.1432-1327.2000.01370.x","article-title":"Physicochemical characteristics of triacyl lipid A partial structure OM-174 in relation to biological activity","volume":"267","author":"Brandenburg","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejphar.2007.02.018_bib15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/0092-8674(94)90007-8","article-title":"Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels","volume":"79","author":"Brooks","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2007.02.018_bib16","first-page":"5863","article-title":"The hypoxic cell: a target for selective cancer therapy \u2014 18th Bruce F. Cain Memorial Award lecture","volume":"59","author":"Brown","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bbrc.2005.02.188","article-title":"TNF-alpha promotes Doxorubicin-induced cell apoptosis and anti-cancer effect through downregulation of p21 in p53-deficient tumor cells","volume":"330","author":"Co","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1359-6446(99)01336-7","article-title":"Strategies for the control of LPS-mediated pathophysiological disorders","volume":"4","author":"Chaby","year":"1999","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2007.02.018_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0305-7372(02)00047-6","article-title":"Adjuvant therapy in colon cancer: current status and future directions","volume":"28","author":"Chau","year":"2002","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ejphar.2007.02.018_bib20","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/annonc\/mdl029","article-title":"Adjuvant therapy in colon cancer\u2013what, when and how?","volume":"17","author":"Chau","year":"2006","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/ijc.10412","article-title":"Activation of Kupffer cells inhibits tumor growth in a murine model system","volume":"99","author":"Chen","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib22","first-page":"389","article-title":"The treatment of inoperable sarcoma with the mixed toxins of erysipelas and bacillus prodigiosus","volume":"31","author":"Coley","year":"1989","journal-title":"Am. Med. Assoc."},{"key":"10.1016\/j.ejphar.2007.02.018_bib23","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.intimp.2005.02.013","article-title":"Antitumour effect of OM-174 and Cyclophosphamide on murine B16 melanoma in different experimental conditions","volume":"5","author":"D'Agostini","year":"2005","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1040-8428(02)00159-2","article-title":"Immunology and immunotherapy of colorectal cancer","volume":"46","author":"Dalerba","year":"2003","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib25","first-page":"397","article-title":"Phase I study of ONO-4007, a synthetic analogue of the lipid A moiety of bacterial lipopolysaccharide","volume":"6","author":"De Bono","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.ejphar.2007.02.018_bib27","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.ijrobp.2006.07.1381","article-title":"The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase","volume":"66","author":"De Ridder","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ejphar.2007.02.018_bib26","unstructured":"Deidier, A., 1725. Deux dissertations m\u00e9dicinales et chirurgicales, l'une sur la maladie v\u00e9n\u00e9rienne, l'autre sur la nature et la curation des tumeurs. C.M. D'Houry, imprimeur, Paris."},{"key":"10.1016\/j.ejphar.2007.02.018_bib28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1286-4579(02)01613-1","article-title":"Toll receptors, CD14, and macrophage activation and deactivation by LPS","volume":"4","author":"Dobrovolskaia","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1016\/j.ejphar.2007.02.018_bib29","first-page":"38","article-title":"Experimental studies on antitumor activity of new recombinant human tumour necrosis factor in nude mice bearing nasopharyngeal carcinoma","volume":"33","author":"Dong","year":"1998","journal-title":"Zhonghua Er Bi Yan Hou Ke Za Zhi"},{"key":"10.1016\/j.ejphar.2007.02.018_bib30","first-page":"555","article-title":"Experimental studies on antitumor effect by the new recombinant tumour necrosis factor and cyclophosphamide in nude mice bearing laryngeal carcinoma","volume":"15","author":"Dong","year":"2001","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"10.1016\/j.ejphar.2007.02.018_bib31","doi-asserted-by":"crossref","first-page":"668","DOI":"10.12968\/hosp.2004.65.11.17046","article-title":"Melanoma vaccines","volume":"65","author":"Elliott","year":"2004","journal-title":"Hosp. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.2910530521","article-title":"Tumor-necrosis factor can enhance radio-antibody uptake in human colon carcinoma xenografts by increasing vascular permeability","volume":"53","author":"Folli","year":"1993","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib33","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/01.ju.0000081126.71235.e0","article-title":"Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate","volume":"170","author":"Frederiksen","year":"2003","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0360-3016(88)90002-8","article-title":"Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy","volume":"14","author":"Gatenby","year":"1988","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ejphar.2007.02.018_bib35","first-page":"671","volume":"12","author":"Gershanovich","year":"2001","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.ejphar.2007.02.018_bib36","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.20050463","article-title":"Tumor cells convert immature myeloid dendritic cells into TGF-\u03b2-secreting cells inducing CD4+CD25+ regulatory T cell proliferation","volume":"202","author":"Ghiringhelli","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ncponc0426","article-title":"Technology insight: utility of TNF-alpha-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities","volume":"3","author":"Grunhagen","year":"2006","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc704","article-title":"Hypoxia \u2014 a key regulatory factor in tumour growth","volume":"2","author":"Harris","year":"2002","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF01518513","article-title":"Cytokine combinations in immunotherapy for solid tumors: a review","volume":"37","author":"Heaton","year":"1993","journal-title":"Cancer Immunol. Immunother."},{"issue":"No 14S","key":"10.1016\/j.ejphar.2007.02.018_bib40","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1200\/jco.2004.22.14_suppl.5520","article-title":"Superiority of tirapazamine-containing chemoradiation in head and neck cancers showing evidence of hypoxia on 18F-misonidazole (FMISO) pet scanning","volume":"22","author":"Hicks","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4049\/jimmunol.174.1.41","article-title":"Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis","volume":"174","author":"Hill","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1574-695X.1996.tb00126.x","article-title":"Biochemistry and cell biology of bacterial endotoxins","volume":"16","author":"Holst","year":"1996","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib43","doi-asserted-by":"crossref","first-page":"R608","DOI":"10.1152\/ajpregu.00538.2003","article-title":"HIFs and tumors \u2014 causes and consequences","volume":"286","author":"H\u00f6pfl","year":"2004","journal-title":"Am. J. Physiol., Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib44","first-page":"1329","article-title":"Transient tumor marker elevation following chemotherapy for germ cell tumors of the testis","volume":"70","author":"Horwich","year":"1986","journal-title":"Cancer Treat. Rep."},{"key":"10.1016\/j.ejphar.2007.02.018_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1359-6101(01)00038-7","article-title":"The roles of IFN-\u03b3 in protection against tumor development and cancer immunoediting","volume":"13","author":"Ikeda","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ejphar.2007.02.018_bib46","first-page":"3957","article-title":"Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions","volume":"18","author":"Inagawa","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s101560050050","article-title":"Effect of interleukin-10 (IL-10) on experimental LPS-induced acute lung injury","volume":"6","author":"Inoue","year":"2000","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.ejphar.2007.02.018_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/scientificamerican0794-58","article-title":"Barriers to drug delivery in solid tumors","volume":"271","author":"Jain","year":"1994","journal-title":"Sci. Am."},{"key":"10.1016\/j.ejphar.2007.02.018_bib49","first-page":"1605","article-title":"Understanding barriers to drug delivery: high resolution in vivo imaging is key","volume":"5","author":"Jain","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib50","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1182\/blood.V97.7.1942","article-title":"A prospective randomized phase II trial of GM-CSF priming to prevent topotecan-induced neutropenia in chemotherapy-naive patients with malignant melanoma or renal cell carcinoma","volume":"97","author":"Janik","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2007.02.018_bib51","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/0006-291X(89)92507-2","article-title":"Induction of differentiation of human monoblastic and myeloblastic leukemia cell lines by TNF muteins","volume":"160","author":"Kamijo","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib52","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1182\/blood.V90.4.1673","article-title":"Downregulation of the proinflammatory cytokine response to endotoxin by pretreatment with the nontoxic lipid A analog SDZ MRL 953 in cancer patients","volume":"90","author":"Kiani","year":"1997","journal-title":"Blood."},{"key":"10.1016\/j.ejphar.2007.02.018_bib53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1040-8428(01)00203-7","article-title":"A potential role of macrophage activation in the treatment of cancer","volume":"44","author":"Klimp","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib54","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1073\/pnas.0400171101","article-title":"TLR2 is expressed on activated T cells as a costimulatory receptor","volume":"101","author":"Komai-Koma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2007.02.018_bib55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00123392","article-title":"Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules","volume":"14","author":"Kong","year":"1996","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.ejphar.2007.02.018_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1089-8603(02)00142-8","article-title":"Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance","volume":"8","author":"Konovalova","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2007.02.018_bib57","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/07357909709047593","article-title":"Antitumor effect of DT-5461, a lipid A derivative, against human tumor xenografts is mediated by intratumoral production of tumor necrosis factor and affected by host immunosuppressive factors in nude mice","volume":"15","author":"Kumazawa","year":"1997","journal-title":"Cancer Investig."},{"key":"10.1016\/j.ejphar.2007.02.018_bib58","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00001813-199706000-00013","article-title":"A new synthetic lipid A analog, ONO-4007, stimulates the production of tumor necrosis factor-alpha in tumor tissues, resulting in the rejection of transplanted rat hepatoma cells","volume":"8","author":"Kuramitsu","year":"1997","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ejphar.2007.02.018_bib59","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0002-9440(10)65444-2","article-title":"Evidence for control of nitric oxide synthesis by intracellular transforming growth factor-\u03b21 in tumor cells","volume":"154","author":"Lagadec","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib60","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrc1613","article-title":"Immunotherapy and chemotherapy \u2014 a practical partnership","volume":"5","author":"Lake","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib61","first-page":"355","article-title":"Kinetics of tumour cell apoptosis and immune cell activation during the regression of tumours induced by lipid A in a rat model of colon cancer","volume":"13","author":"Larmonier","year":"2004","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib62","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.semcancer.2005.04.004","article-title":"Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin","volume":"15","author":"Lechner","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib63","doi-asserted-by":"crossref","first-page":"13451","DOI":"10.1074\/jbc.274.19.13451","article-title":"PG490 (Triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells","volume":"274","author":"Lee","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.02.018_bib64","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nm0702-667","article-title":"Burning up TNF toxicity for cancer therapy","volume":"8","author":"Leist","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib65","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1172\/JCI0216493","article-title":"Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability","volume":"110","author":"Lejeune","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2007.02.018_bib66","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0952-7915(98)80226-4","article-title":"Clinical applications of TNF-\u03b1 in cancer","volume":"10","author":"Lejeune","year":"1998","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib67","doi-asserted-by":"crossref","first-page":"C227","DOI":"10.1152\/ajpcell.00112.2001","article-title":"Reactive species mechanisms of cellular hypoxia-reoxygenation injury","volume":"282","author":"Li","year":"2002","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib68","first-page":"2531","article-title":"Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells","volume":"51","author":"Li","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1200\/JCO.1986.4.1.46","article-title":"Prospective evaluation of carcinoembryonic antigen levels and alternating chemotherapeutic regimens in metastatic breast cancer","volume":"4","author":"Loprinzi","year":"1986","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib70","first-page":"36","article-title":"Malignant melanoma-future prospects","volume":"13","author":"Lugovic","year":"2005","journal-title":"Acta Dermatovenerol. Croat."},{"key":"10.1016\/j.ejphar.2007.02.018_bib71","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S1470-2045(05)70315-6","article-title":"P53 as a prognostic marker for bladder cancer: a meta-analysis and review","volume":"6","author":"Malats","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib72","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.20030448","article-title":"Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming","volume":"198","author":"Martin-Fontecha","year":"2003","journal-title":"J. Exp. Med."},{"issue":"suppl.2","key":"10.1016\/j.ejphar.2007.02.018_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000474912","article-title":"BCG for superficial bladder cancer","volume":"21","author":"Martinez-Pi\u00f1eiro","year":"1992","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib74","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0192-0561(00)00074-6","article-title":"Immunomodulators in infectious diseases: panoply of possibilites","volume":"22","author":"Masihi","year":"2000","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib75","first-page":"4283","article-title":"Intratumoral tumor necrosis factor induction and tumor growth suppression by ONO-4007, a low-toxicity lipid A analog","volume":"18","author":"Matsumoto","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib76","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0022-3565(24)37219-2","article-title":"ONO-4007, an antitumor lipid A analog, induces tumor necrosis factor-alpha production by human monocytes only under primed state: different effects of ONO-4007 and lipopolysaccharide on cytokine production","volume":"284","author":"Matsumoto","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.02.018_bib77","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00001813-199803000-00010","article-title":"ONO-4007 induces specific anti-tumor immunity mediated by tumor necrosis factor-alpha","volume":"9","author":"Matsushita","year":"1998","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ejphar.2007.02.018_bib78","first-page":"489","article-title":"ONO-4007, a synthetic lipid A analog, induces Th1-type immune response in tumor eradication and restores nitric oxide production by peritoneal macrophages","volume":"23","author":"Matsushita","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib79","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.7189295","article-title":"Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate","volume":"208","author":"McLaughlin","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2007.02.018_bib80","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0264-410X(03)00093-8","article-title":"OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242\u2013310 from the circumsporozoite protein of Plasmodium berghei","volume":"21","author":"Meraldi","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ejphar.2007.02.018_bib81","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cytogfr.2003.11.001","article-title":"The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle","volume":"15","author":"Mocellin","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ejphar.2007.02.018_bib82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cytogfr.2004.11.001","article-title":"Tumor necrosis factor, cancer and anticancer therapy","volume":"16","author":"Mocellin","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ejphar.2007.02.018_bib83","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.it.2005.06.009","article-title":"TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway","volume":"26","author":"Moynagh","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib84","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-5347(17)58737-6","article-title":"Intracavitary bacillus Calmette-Gu\u00e9rin in the treatment of superficial bladder tumors","volume":"116","author":"Morales","year":"1976","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib85","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2004.05.025","article-title":"High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer","volume":"216","author":"Mortensen","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2007.02.018_bib86","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.bjc.6602358","article-title":"P53 abnormalities and outcomes in colorectal cancer: a systematic review","volume":"92","author":"Munro","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib87","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/ijc.2910480519","article-title":"A novel recombinant tumor necrosis factor-alpha mutant with increased anti-tumor activity and lower toxicity","volume":"48","author":"Nakamura","year":"1991","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib88","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0192-0561(91)90020-8","article-title":"Inhibition in mice of experimental metastasis of B16 melanoma by the synthetic lipid A-subunit analogue GLA-60","volume":"13","author":"Nakatsuka","year":"1991","journal-title":"Intl. J. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib89","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0264-410X(96)00193-4","article-title":"Romurtide, a synthetic muramyl dipeptide derivative, promotes megakaryocytopoiesis through stimulation of cytokine production in nonhuman primates with myelosuppression","volume":"15","author":"Namba","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.ejphar.2007.02.018_bib90","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/CDLI.4.5.607-610.1997","article-title":"Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10","volume":"4","author":"Nicoletti","year":"1997","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib91","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1097\/00003246-200209000-00019","article-title":"Tumor necrosis factor-alpha and interleukin-1beta mediate endothelial permeability induced by lipopolysaccharide-stimulated whole blood","volume":"30","author":"Nooteboom","year":"2002","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib92","first-page":"564","article-title":"Priming effect of orally administered muramyl dipeptide on inductio of endogenous tumor necrosis factor","volume":"9","author":"Okutomi","year":"1990","journal-title":"J. Biol. Response Modif."},{"key":"10.1016\/j.ejphar.2007.02.018_bib93","first-page":"329","article-title":"Imunovir in the treatment of immunodepression of diverse etiology","volume":"1","author":"O'Neill","year":"1987","journal-title":"Cancer Detect. Prev., Suppl."},{"key":"10.1016\/j.ejphar.2007.02.018_bib94","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/(SICI)1097-0215(19990531)81:5<755::AID-IJC15>3.0.CO;2-3","article-title":"Expression of inducible nitric oxide synthase in tumors in relation with their regression induced by lipid A in rats","volume":"81","author":"Onier","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib95","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1006663017149","article-title":"Cure of colon cancer metastasis in rats with the new lipid A OM 174. Apoptosis of tumour cells and immunization of rats","volume":"17","author":"Onier","year":"1999","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.ejphar.2007.02.018_bib96","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.semcancer.2003.09.008","article-title":"Dendritic cells as vectors for immunotherapy of cancer","volume":"13","author":"Paczesny","year":"2003","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib97","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0264-410X(02)00529-7","article-title":"The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo","volume":"14","author":"Pajak","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ejphar.2007.02.018_bib98","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1182\/blood.V89.8.2701","article-title":"Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia","volume":"89","author":"Pajkrt","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2007.02.018_bib100","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1128\/IAI.61.5.2015-2023.1993","article-title":"Induction of early gene expression in murine macrophages by synthetic lipid A analogs with differing endotoxic potentials","volume":"61","author":"Perera","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib101","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.vaccine.2004.01.021","article-title":"4th Meeting on novel adjuvants currently in\/close to human clinical testing. World Health Organization. Fondation M\u00e9rieux, Annecy, France, 23\u201325 June 2003","volume":"22","author":"Pink","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.ejphar.2007.02.018_bib102","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jss.2003.09.008","article-title":"Direct visualization of nitric oxide release by liver cells after the arrest of metastatic tumor cells in the hepatic microvasculature","volume":"119","author":"Qi","year":"2004","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib103","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0014-5793(93)81693-T","article-title":"Interleukin-10 inhibits endotoxin-induced tissue factor mRNA production by human monocytes","volume":"334","author":"Ramani","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2007.02.018_bib104","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.imbio.2004.03.005","article-title":"Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunity","volume":"209","author":"Re","year":"2004","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejphar.2007.02.018_bib105","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.4049\/jimmunol.173.12.7548","article-title":"IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells","volume":"173","author":"Re","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib106","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/bies.10053","article-title":"Mechanisms of the antitumoral effect of lipid A","volume":"24","author":"Reisser","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.ejphar.2007.02.018_bib107","first-page":"4756","article-title":"Enhancement of endotoxic shock by N-acetylmuramyl-l-alanyl-(l-seryl)-d-isoglutamine (muramyl dipeptide)","volume":"39","author":"Ribi","year":"1979","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib108","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/01.coc.0000027268.23258.7D","article-title":"Hematopoietic protection by dexamethasone or granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients treated with carboplatin and ifosfamide","volume":"26","author":"Rinehart","year":"2003","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib109","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nm0498-408","article-title":"Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma","volume":"4","author":"Ruegg","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib110","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2760::AID-IMMU2760>3.0.CO;2-N","article-title":"Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation","volume":"28","author":"Sallusto","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib111","series-title":"The 5th Annual Conference on Vaccine Research. Baltimore May 6\u20138, 2002","article-title":"The novel adjuvant OM-174 activates murine bone marrow dendritic cells through TLR-4 and can also signal through human TLR2","author":"Samsom","year":"2002"},{"key":"10.1016\/j.ejphar.2007.02.018_bib112","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1006\/bbrc.2000.2835","article-title":"Synergistic induction of apoptosis in murine hepatoma Hepa1\u20136 cells by IFN-\u03b3 and TNF-\u03b1","volume":"272","author":"Sasagawa","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib113","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1349-7006.1992.tb02725.x","article-title":"DT-5461, a new synthetic lipid A analogue, inhibits lung and liver metastasis of tumor in mice","volume":"83","author":"Sato","year":"1992","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib114","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1128\/IAI.63.8.2859-2866.1995","article-title":"A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia","volume":"63","author":"Sato","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib115","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1349-7006.1995.tb03067.x","article-title":"Inhibition of tumor-induced angiogenesis by a synthetic lipid A analogue with low endotoxicity, DT-5461","volume":"836","author":"Sato","year":"1995","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib116","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/gut.2003.026005","article-title":"Tumour suppression induced by the macrophage activating lipopeptide MALP-2 in an ultrasound guided pancreatic carcinoma mouse model","volume":"53","author":"Schneider","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2007.02.018_bib117","first-page":"81","article-title":"Chemical treatment of tumor: V. Isolation of the hemorrhage-producing fraction from Serratia marcescens (Bacillus prodigiosus) culture filtrate","volume":"4","author":"Shear","year":"1943","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejphar.2007.02.018_bib118","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jcp.1040800114","article-title":"Studies on the bone marrow colony stimulating factor (CSF): relation of tissue CSF to serum CSF","volume":"80","author":"Sheridan","year":"1972","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib119","first-page":"785","article-title":"Transient tumor marker surge following chemotherapy of testis tumors","volume":"71","author":"Shetty","year":"1987","journal-title":"Cancer Treat. Rep."},{"key":"10.1016\/j.ejphar.2007.02.018_bib120","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrc1208","article-title":"Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer","volume":"3","author":"Siegel","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib121","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1200\/JCO.2003.99.200","article-title":"Carcinoembryonic antigen surge in metastatic colorectal cancer patients responding to oxaliplatin combination chemotherapy: implications for tumor marker monitoring and guidelines","volume":"21","author":"S\u00f8rbye","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib122","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0002-9440(10)64986-3","article-title":"Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature","volume":"156","author":"Stoelcker","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib123","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1056\/NEJM198905043201802","article-title":"Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects","volume":"320","author":"Suffredini","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib125","first-page":"2654","article-title":"Isolation of a nontoxic lipid A fraction containing tumor regression activity","volume":"41","author":"Takayama","year":"1981","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib127","first-page":"1823","article-title":"Profile of cytokines produced in tumor tissue after administration of cyclophosphamide in a combination therapy with tumor necrosis factor","volume":"24","author":"Takiguchi","year":"2004","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib128","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1471-4906(00)01850-0","article-title":"TNF is here to stay-revisited","volume":"22","author":"ten Hagen","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib129","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.it.2004.02.013","article-title":"Mast cells: the Jekyll and Hyde of tumor growth","volume":"25","author":"Theoharides","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib130","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1128\/IAI.68.12.6883-6890.2000","article-title":"Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Gu\u00e9rin: involvement of Toll-like receptors","volume":"68","author":"Tsuji","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib131","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1567-5769(00)00017-5","article-title":"Induction of tumor necrosis factor-a in solid tumor regio by the orally administered synthetic muramyl dipeptide analogue, romurtide","volume":"1","author":"Ueda","year":"2001","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib132","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/IAI.71.8.4238-4249.2003","article-title":"Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by mycobacterium bovis bacillus Calmette-Gu\u00e9rin peptidoglycan","volume":"71","author":"Uehori","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2007.02.018_bib133","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0065-230X(01)82004-2","article-title":"Nitric oxide-induced apoptosis in tumor cells","volume":"82","author":"Umansky","year":"2001","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib134","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1054\/bjoc.2000.1719","article-title":"Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase","volume":"84","author":"Van den Berge","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1570-9124(03)00016-3","article-title":"BCG immunotherapy for superficial bladder cancer: an overview of the past, the present and the future","volume":"1","author":"Van der Meijden","year":"2003","journal-title":"EAU Update Ser."},{"key":"10.1016\/j.ejphar.2007.02.018_bib136","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/eji.200323830","article-title":"Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells","volume":"33","author":"Varadaradjalou","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib138","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(98)07186-4","article-title":"Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial","volume":"353","author":"Vermorken","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2007.02.018_bib139","first-page":"171","article-title":"The protective activity of Thymex L against radiotherapeutically-induced cellular immunodepression in lung cancer patients","volume":"39","author":"Vuckovic-Dekic","year":"1992","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejphar.2007.02.018_bib140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cytogfr.2004.12.001","article-title":"Tumor therapeutics by design: targeting and activation of death receptors","volume":"16","author":"Wajant","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ejphar.2007.02.018_bib141","first-page":"5862","article-title":"B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal cytotoxicity: a natural hepatic defense against metastasis","volume":"60","author":"Wang","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.02.018_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma","volume":"324","author":"Weidner","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib143","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jnci\/83.1.37","article-title":"Effect of prior cancer chemotherapy on human tumor-specific cytotoxicity in vitro in response to immunopotentiating biologic response modifiers","volume":"83","author":"Weisenthal","year":"1991","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejphar.2007.02.018_bib144","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0163-7258(94)90023-X","article-title":"Coley's next term toxins, tumor necrosis factor and cancer research: a historical perspective","volume":"64","author":"Wiemannn","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2007.02.018_bib145","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jneuroim.2005.04.018","article-title":"A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis","volume":"165","author":"Wilson","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib146","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0891-5849(02)01364-3","article-title":"Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency","volume":"34","author":"Xie","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2007.02.018_bib147","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.4049\/jimmunol.172.7.4599","article-title":"Treatment of melanoma with 5-fluorouracil or dacarbazine in vitro sensitizes cells to antigen-specific CTL Lysis through perforin\/granzyme- and Fas-mediated pathways","volume":"172","author":"Yang","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2007.02.018_bib148","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF01525505","article-title":"Activation of tumor-infiltrating macrophages by a synthetic lipid A analog (ONO-4007) and its implication in antitumor effects","volume":"38","author":"Yang","year":"1994","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.ejphar.2007.02.018_bib149","first-page":"375","article-title":"Establishment and characterization of rat myelomonocytic leukemia clones undergoing differentiation or apoptosis","volume":"75","author":"Yoshida","year":"2000","journal-title":"Hokkaido Igaku Zasshi"},{"key":"10.1016\/j.ejphar.2007.02.018_bib150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1248\/bpb.27.437","article-title":"Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy","volume":"27","author":"Yoshioka","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2007.02.018_bib151","first-page":"42","article-title":"A multicenter randomized phase II trial of domestic product of nrhTNF in the treatment of non-small cell lung cancer","volume":"6","author":"Zhou","year":"2003","journal-title":"Chin. J. Lung Cancer"},{"key":"10.1016\/j.ejphar.2007.02.018_bib152","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/IAI.73.2.935-943.2005","article-title":"Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein","volume":"73","author":"Zhou","year":"2005","journal-title":"Infect. Immun."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907002051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907002051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T21:43:17Z","timestamp":1736804597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907002051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":149,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0014299907002051"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.02.018","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}