{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:37:42Z","timestamp":1783953462813,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.ejphar.2007.03.015","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T11:16:30Z","timestamp":1174994190000},"page":"77-82","source":"Crossref","is-referenced-by-count":23,"title":["Chronically administered fluoxetine enhances the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model"],"prefix":"10.1016","volume":"567","author":[{"given":"Kinga K.","family":"Borowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Furmanek-Karwowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Sawicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarogniew J.","family":"Luszczki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislaw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2007.03.015_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000134913","article-title":"Une nouvelle methode simple pour explorer l'action tranquilisante: le test de la cheminee","volume":"3","author":"Boissier","year":"1960","journal-title":"Med. Exp. (Basel)"},{"key":"10.1016\/j.ejphar.2007.03.015_bib1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.neuropharm.2005.11.020","article-title":"Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis","volume":"50","author":"Boothman","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2007.03.015_bib2","first-page":"83","article-title":"Fluoxetine enhances the anticonvulsant effects of conventional antiepileptic drugs in maximal electroshock seizures in mice","volume":"58","author":"Borowicz","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2007.03.015_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(97)01215-6","article-title":"Enhancement of the anticonvulsant effect of fluoxetine following blockade of 5-HT1 receptors","volume":"336","author":"Browning","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.03.015_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jpsychires.2004.06.002","article-title":"Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats","volume":"39","author":"Ceyhan","year":"2005","journal-title":"J. Psychiat. Res."},{"key":"10.1016\/j.ejphar.2007.03.015_bib5","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0028-3908(99)00206-3","article-title":"Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells","volume":"39","author":"Deak","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2007.03.015_bib6","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1212\/WNL.45.10.1926","article-title":"Anticonvulsant effect of fluoxetine in humans","volume":"45","author":"Favale","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2007.03.015_bib7","first-page":"471","article-title":"Drug\u2013drug interaction in reverse: toxic reaction following the combined administration of fluoxetine and phenytoin, two case reports","volume":"19","author":"Jalil","year":"1999","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2007.03.015_bib8","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.yebeh.2003.08.020","article-title":"Common pathogenic mechanisms between depression and epilepsy: an experimental perspective","volume":"4","author":"Jobe","year":"2003","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2007.03.015_bib9","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.yebeh.2005.07.014","article-title":"The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant","volume":"7","author":"Jobe","year":"2005","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2007.03.015_bib10","first-page":"85","article-title":"Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice","volume":"34","author":"Kleinrok","year":"1991","journal-title":"J. Neural Transm., Suppl."},{"key":"10.1016\/j.ejphar.2007.03.015_bib12","first-page":"29","article-title":"Calcium modulation in epilepsy","volume":"56","author":"Kulak","year":"2004","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.03.015_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1528-1157.1992.tb01712.x","article-title":"Fluoxetine, a selective serotonin-uptake inhibitor, enhances the anticonvulsant effect of phenytoin, carbamazepine and ameltolide (LY101116)","volume":"33","author":"Leander","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2007.03.015_bib16","first-page":"99","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.03.015_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2005.07.049","article-title":"Inhibition of serotonin transporters by cocaine and meprylcaine through 5-HT2C receptor stimulation facilitates their seizure activities","volume":"28","author":"Morita","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2007.03.015_bib17","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.neuropharm.2005.06.017","article-title":"Selective cortical VGLUT1 increase as a marker for antidepressant activity","volume":"49","author":"Moutsimilli","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2007.03.015_bib18","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1073\/pnas.94.5.2036","article-title":"Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)","volume":"94","author":"Ni","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2007.03.015_bib19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1471-4159.2001.00254.x","article-title":"5-HT1 receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotoninergic neurotransmission","volume":"77","author":"Parsons","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2007.03.015_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0006-8993(96)00291-0","article-title":"The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin","volume":"724","author":"Pasini","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2007.03.015_bib24","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0704555","article-title":"Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S-GTP gamma S autoradiography","volume":"135","author":"Pejchal","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.03.015_bib25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2004.11.025","article-title":"Anticonvulsant effects of acute and repeated fluoxetine treatment in unstressed and stressed mice","volume":"1033","author":"Pericic","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2007.03.015_bib26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0014-2999(90)90190-H","article-title":"Modulation of morphine antinociception by peripheral [Leu5] enkephalin: a synergistic interaction","volume":"179","author":"Porecca","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.03.015_bib40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1528-1157.1993.tb02425.x","article-title":"Anticonvulsant effect of fluoxetine on focally evoked limbic motor seizures in rats","volume":"34","author":"Prendiville","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2007.03.015_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1006\/phrs.1999.0466","article-title":"Effect of fluoxetine on maximal electroshock seizures in mice: acute vs chronic administration","volume":"39","author":"Raju","year":"1999","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2007.03.015_bib28","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1046\/j.1471-4159.1997.68062593.x","article-title":"Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors","volume":"68","author":"Romero","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2007.03.015_bib29","first-page":"289","article-title":"Seizures associated with antidepressants: a review","volume":"54","author":"Rosenstein","year":"1993","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2007.03.015_bib30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1054\/jocn.2000.0896","article-title":"Epilepsy, depression and antidepressant drugs","volume":"8","author":"Salzberg","year":"2001","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2007.03.015_bib31","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/0024-3205(96)00519-X","article-title":"Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats","volume":"69","author":"Statnick","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2007.03.015_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2004.07.018","article-title":"Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice","volume":"1023","author":"Ugale","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2007.03.015_bib35","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/321864a0","article-title":"Benzodiazepines impair and beta-carbolines enhance performance in learning and memory tasks","volume":"321","author":"Venault","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2007.03.015_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00321-3","article-title":"Pindolol potentiates the effects the effect of fluoxetine on hippocampal seizures in rats","volume":"267","author":"Wada","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2007.03.015_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2004.06.072","article-title":"Chronic antidepressant treatment alters serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons","volume":"129","author":"Zhong","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2007.03.015_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neulet.2004.10.009","article-title":"The effect of fluoxetine in a model of chemically induced seizures-behavioral and immunocytochemical study","volume":"373","author":"Zienowicz","year":"2005","journal-title":"Neurosci. Lett."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907003615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907003615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T15:58:40Z","timestamp":1546963120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907003615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0014299907003615"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.03.015","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}