{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:37:06Z","timestamp":1793223426679,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.ejphar.2007.04.046","type":"journal-article","created":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T07:47:12Z","timestamp":1178869632000},"page":"126-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cyclooxygenase-2 inhibitor ameliorates ureteric damage in rats with obstructed uropathy"],"prefix":"10.1016","volume":"569","author":[{"given":"Yen-Hwang","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Long","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Pin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsiung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2007.04.046_bib1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1136\/ard.2005.046920","article-title":"Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac","volume":"65","author":"Alvarez-Soria","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2007.04.046_bib2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/CIRCULATIONAHA.106.181424","article-title":"Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American heart association","volume":"115","author":"Antman","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2007.04.046_bib3","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1074\/jbc.275.4.2837","article-title":"Regulation of Cyclooxygenase-2 by hypoxia and peroxisome proliferation in the corneal epithelium","volume":"275","author":"Bonazzi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.04.046_bib4","first-page":"1286","article-title":"Transforming growth factor-\u03b2 in tissue fibrosis","volume":"10","author":"Border","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2007.04.046_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1464-410X.1998.00725.x","article-title":"Tissue damage and regeneration of the ureteric smooth muscle in rat with obstructive uropathy","volume":"82","author":"Chuang","year":"1998","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib6","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S0022-5347(05)67767-1","article-title":"Expression of transforming growth factor-\u03b21 and its receptors related to the ureteric fibrosis in a rat model of obstructive uropathy","volume":"163","author":"Chuang","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0090-4295(01)01260-2","article-title":"Myocyte apoptosis in the pathogenesis of ureteral damage in rats with obstructive uropathy","volume":"58","author":"Chuang","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.ejphar.2007.04.046_bib8","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2165\/00003495-200059040-00017","article-title":"Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis, and acute pain","volume":"59","author":"Clemett","year":"2000","journal-title":"Drug"},{"key":"10.1016\/j.ejphar.2007.04.046_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-2999(01)01403-0","article-title":"Celecoxib, a selective cyclooxygenase-2 inhibitor reduces the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats","volume":"431","author":"Cuzzocrea","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib10","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1056\/NEJMp048288","article-title":"Coxibs and cardiovascular disease","volume":"351","author":"FitzGerald","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2007.04.046_bib11","series-title":"Campbell's Urology","first-page":"411","article-title":"The pathophysiology of urinary tract obstruction","author":"Gulmi","year":"2002"},{"key":"10.1016\/j.ejphar.2007.04.046_bib12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.300.2.367","article-title":"Cyclooxygenase-2\u201310 years late","volume":"300","author":"Hinz","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.04.046_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.plefa.2003.07.001","article-title":"Cyclooxygenase-2 (COX-2)-prostanoid pathway and liver diseases","volume":"69","author":"Hu","year":"2003","journal-title":"Prostaglandins Leukot. Essent."},{"key":"10.1016\/j.ejphar.2007.04.046_bib14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ki.1997.95","article-title":"Renal microcirculation and tissue damage during acute ureteral obstruction in the rat: effect of saline infusion, indomethacin and radiocontrast","volume":"51","author":"Heyman","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2007.04.046_bib15","first-page":"4510","article-title":"Induction of apoptosis in proliferation human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4","volume":"58","author":"Iyer","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.04.046_bib16","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1345\/aph.18415","article-title":"The cyclooxygenase-2 inhibitors: safety and effectiveness","volume":"33","author":"Kaplan-Machlis","year":"1999","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.ejphar.2007.04.046_bib17","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0002-9440(10)64092-8","article-title":"Cyclooxygenase-2 deficiency results in a loss of the anti-proliferation response to transforming growth factor-1 in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice","volume":"154","author":"Keerthisingam","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib18","doi-asserted-by":"crossref","first-page":"H1416","DOI":"10.1152\/ajpheart.00136.2003","article-title":"Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse","volume":"286","author":"LaPointe","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0022-5347(17)38710-4","article-title":"Renal injury and recovery in partial ureteric obstruction","volume":"142","author":"Leahy","year":"1989","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1074\/mcp.M300108-MCP200","article-title":"Transforming growth factor-beta 1 specifically induce proteins involved in the myofibroblast contractile apparatus","volume":"3","author":"Malmstrom","year":"2004","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.ejphar.2007.04.046_bib21","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/rheumatology\/41.7.801","article-title":"Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage","volume":"41","author":"Mastbergen","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2007.04.046_bib22","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1046\/j.1523-1755.2000.00414.x","article-title":"Antibody to transforming growth factor-\u03b2 ameliorates tubular apoptosis in unilateral ureteral obstruction","volume":"58","author":"Miyajima","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2007.04.046_bib23","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0022-5347(05)66400-2","article-title":"Tranilast ameliorates renal tubular damage in unilateral ureteral obstruction","volume":"165","author":"Miyajima","year":"2001","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0022-5347(05)65933-2","article-title":"Does cyclooxygenase-2 inhibitor prevent renal tissue damage in unilateral ureteral obstruction","volume":"166","author":"Miyajima","year":"2001","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib25","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0022-5347(05)64630-7","article-title":"Cyclooxygenase-2 expression is up-regulated in obstructed human ureter","volume":"168","author":"Nakada","year":"2002","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/pros.20331","article-title":"Adenocarcinoma of the mouse prostate growth inhibition by Celecoxib: downregulation of transcription factors involved in COX-2 inhibition","volume":"66","author":"Narayanan","year":"2006","journal-title":"Prostate"},{"key":"10.1016\/j.ejphar.2007.04.046_bib27","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/sj.ki.5001616","article-title":"Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction","volume":"70","author":"Norregaard","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2007.04.046_bib28","first-page":"F129","article-title":"Obstruction stimulates Cox-2 expression in bladder smooth muscle cells via increased mechanical stretch","volume":"276","author":"Park","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2007.04.046_bib29","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1096\/fj.04-2753fje","article-title":"The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPAR\u03b3 activation","volume":"19","author":"Planaguma","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2007.04.046_bib30","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1158\/0008-5472.CAN-05-0212","article-title":"Prevention of colon cancer by low doses of Celecoxib, a cyclooxygenase inhibitor, administered in diet rich in \u03c9-3 polyunsaturated fatty acids","volume":"65","author":"Reddy","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.04.046_bib31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/01.WCB.0000100065.36077.4A","article-title":"Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice","volume":"24","author":"Sasaki","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ejphar.2007.04.046_bib32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/excr.1999.4543","article-title":"Mechanisms of myofibroblast activity and phenotype modulation","volume":"250","author":"Serini","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2007.04.046_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenase: structure, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2007.04.046_bib34","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1158\/0008-5472.CAN-05-4619","article-title":"Chemoprevention of familial adenomatous polyposis by low doses of Atorvastatin and Celecoxib given individually and in combination to APCmin mice","volume":"66","author":"Swamy","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2007.04.046_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.med.53.082901.103952","article-title":"Cyclooxygenase-2: a therapeutic target","volume":"53","author":"Turini","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ejphar.2007.04.046_bib36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0008-6363(97)00033-3","article-title":"Circulating transforming growth factor 1 and coronary artery disease","volume":"34","author":"Wang","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2007.04.046_bib37","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(93)90457-2","article-title":"Molecular regulation of apoptosis: genetic controls on cell death","volume":"74","author":"Williams","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2007.04.046_bib38","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/BF02388205","article-title":"Update on proliferation-associated antibodies applicable formalin-fixed paraffin-embedded tissue and their clinical applications","volume":"25","author":"Yu","year":"1993","journal-title":"Histochem. J."},{"key":"10.1016\/j.ejphar.2007.04.046_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1750-3639.2000.tb00247.x","article-title":"Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia","volume":"10","author":"Zoppo","year":"2000","journal-title":"Brain Pathol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907005122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907005122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T03:59:12Z","timestamp":1762142352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907005122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":39,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0014299907005122"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.04.046","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclooxygenase-2 inhibitor ameliorates ureteric damage in rats with obstructed uropathy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.04.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}