{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:01:46Z","timestamp":1789560106597,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ejphar.2007.10.013","type":"journal-article","created":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T12:20:25Z","timestamp":1194351625000},"page":"40-49","source":"Crossref","is-referenced-by-count":96,"title":["Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts"],"prefix":"10.1016","volume":"579","author":[{"given":"Chih-Hsin","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yin","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chich","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Mei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2007.10.013_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrd1068","article-title":"Teriparatide","volume":"2","author":"Berg","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2007.10.013_bib2","first-page":"27","article-title":"Transforming growth factor-\u03b2 gene family members and bone","volume":"15","author":"Centrella","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2007.10.013_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1024934008982","article-title":"Advanced glycation end-products induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases","volume":"250","author":"Cortizo","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2007.10.013_bib4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","article-title":"The osteoblast: a sophisticated fibroblast under central surveillance","volume":"289","author":"Ducy","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2007.10.013_bib5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S8756-3282(01)00415-X","article-title":"Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells","volume":"28","author":"Gallea","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2007.10.013_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrd916","article-title":"Discoveries, drugs and skeletal disorders","volume":"1","author":"Goltzman","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2007.10.013_bib7","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1359\/jbmr.2003.18.11.2060","article-title":"Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation","volume":"18","author":"Guicheux","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2007.10.013_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0945-053X(00)00076-7","article-title":"The collagen receptor integrins have distinct ligand recognition and signaling functions","volume":"19","author":"Heino","year":"2000","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejphar.2007.10.013_bib9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/hep.510240307","article-title":"Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro","volume":"24","author":"Huang","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2007.10.013_bib10","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1074\/jbc.275.13.9645","article-title":"Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase","volume":"275","author":"Jaiswal","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.10.013_bib11","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bone.2004.04.007","article-title":"Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation","volume":"35","author":"Kapur","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2007.10.013_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(92)90576-P","article-title":"Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens","volume":"219","author":"Ko","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.10.013_bib13","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1124\/jpet.105.085092","article-title":"Osthole-mediated cell differentiation through bone morphogenetic protein-2\/p38 and extracellular signal-regulated kinase 1\/2 pathway in human osteoblast cells","volume":"314","author":"Kuo","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.10.013_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/ar797","article-title":"A review of anabolic therapies for osteoporosis","volume":"5","author":"Lane","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2007.10.013_bib15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1248\/bpb.25.738","article-title":"Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol","volume":"25","author":"Li","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2007.10.013_bib16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S8756-3282(99)00227-6","article-title":"Donahue HJ. Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells","volume":"25","author":"Li","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2007.10.013_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1055\/s-2006-957507","article-title":"Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase","volume":"64","author":"Liu","year":"1998","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2007.10.013_bib18","first-page":"643","article-title":"Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells","volume":"59","author":"Meng","year":"2004","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejphar.2007.10.013_bib19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cellsig.2003.08.011","article-title":"Signal transduction of bone morphogenetic protein receptors","volume":"16","author":"Nohe","year":"2004","journal-title":"Cell Signal."},{"key":"10.1016\/j.ejphar.2007.10.013_bib20","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/carcin\/bgi303","article-title":"Naturally occurring coumarins inhibit 7, 12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland","volume":"27","author":"Prince","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2007.10.013_bib21","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0959-437X(94)90141-O","article-title":"Bone and cartilage differentiation","volume":"4","author":"Reddi","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejphar.2007.10.013_bib22","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2007.10.013_bib23","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1359\/jbmr.1999.14.7.1145","article-title":"Localization of Smads, the TGF-\u03b2 family intracellular signaling components during endochondral ossification","volume":"14","author":"Sakou","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2007.10.013_bib24","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1210\/en.140.7.3177","article-title":"Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi proteincoupled receptors by epinephrine in osteoblast-like cells","volume":"140","author":"Suzuki","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2007.10.013_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2334\/josnusd.45.57","article-title":"Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician?","volume":"45","author":"Sykaras","year":"2003","journal-title":"J. Oral Sci."},{"key":"10.1016\/j.ejphar.2007.10.013_bib26","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1074\/jbc.M603070200","article-title":"Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice","volume":"282","author":"Tang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.10.013_bib27","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.M500130200","article-title":"Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase C alpha, and c-Src pathway in primary cultured rat osteoblasts","volume":"280","author":"Tang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.10.013_bib28","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0026-895X(24)05626-8","article-title":"Enhancement of fibronectin fibrillogenesis and bone formation by basic fibroblast growth factor via protein kinase C-dependent pathway in rat osteoblasts","volume":"66","author":"Tang","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.10.013_bib29","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1359\/jbmr.2003.18.3.502","article-title":"Enhancement of fibronectin synthesis and fibrillogenesis by BMP-4 in cultured rat osteoblast","volume":"18","author":"Tang","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2007.10.013_bib30","first-page":"202","article-title":"The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea","volume":"349","author":"Teng","year":"1994","journal-title":"Naunyn-Schmiedelberg's Arch. Pharm."},{"key":"10.1016\/j.ejphar.2007.10.013_bib31","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: Formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2007.10.013_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2567.2001.01261.x","article-title":"Nitric oxide and bone","volume":"103","author":"van't Hof","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2007.10.013_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3727\/000000004772664851","article-title":"Development and transplantation of a mineralized matrix formed by osteoblasts in vitro for bone regeneration","volume":"13","author":"Xiao","year":"2004","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejphar.2007.10.013_bib34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bone.2004.10.009","article-title":"Regulation by ultrasound treatment on the integrin expression and differentiation of osteoblasts","volume":"36","author":"Yang","year":"2005","journal-title":"Bone"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907011089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907011089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T03:44:58Z","timestamp":1737517498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907011089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":34,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0014299907011089"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.10.013","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}