{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:57:46Z","timestamp":1773421066545,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ejphar.2007.10.028","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T09:58:26Z","timestamp":1193392706000},"page":"298-307","source":"Crossref","is-referenced-by-count":44,"title":["Myogenic tone and reactivity of cerebral arteries in Type II diabetic BBZDR\/Wor rat"],"prefix":"10.1016","volume":"579","author":[{"given":"Yagna P.R.","family":"Jarajapu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L.","family":"Guberski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria B.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harm J.","family":"Knot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2007.10.028_bib1","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/01.STR.32.6.1408","article-title":"Vasopressin-induced protein kinase C-dependent superoxide generation contributes to atp-sensitive potassium channel but not calcium-sensitive potassium channel function impairment after brain injury","volume":"32","author":"Armstead","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2007.10.028_bib2","first-page":"H2366","article-title":"Endothelial-dependent vasodilation is preserved in non-insulin-dependent Zucker fatty diabetic rats","volume":"268","author":"Bohlen","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib3","doi-asserted-by":"crossref","first-page":"C2090","DOI":"10.1152\/ajpcell.1997.273.6.C2090","article-title":"Activators of protein kinase C decrease Ca2+ spark frequency in smooth muscle cells from cerebral arteries","volume":"273","author":"Bonev","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2007.10.028_bib5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cnur.2006.07.007","article-title":"Diabetes mellitus and cardiovascular disease","volume":"41","author":"Chyun","year":"2006","journal-title":"Nurs. Clin. North Am."},{"key":"10.1016\/j.ejphar.2007.10.028_bib6","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/01.RES.0000020401.61826.EA","article-title":"Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function","volume":"90","author":"Csiszar","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.STR.0000152952.42730.92","article-title":"Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes","volume":"36","author":"Didion","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2007.10.028_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/niox.2001.0419","article-title":"Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ\/WOR rat","volume":"6","author":"Ellis","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2007.10.028_bib9","doi-asserted-by":"crossref","first-page":"H2160","DOI":"10.1152\/ajpheart.00379.2002","article-title":"Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats","volume":"283","author":"Frisbee","year":"2002","journal-title":"Am. J. Physiol, Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11892-007-0033-3","article-title":"Hypertension in people with diabetes and the metabolic syndrome: pathophysiologic insights and therapeutic update","volume":"7","author":"Ganne","year":"2007","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.ejphar.2007.10.028_bib11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.HYP.27.4.849","article-title":"Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans","volume":"27","author":"Gerhard","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2007.10.028_bib12","doi-asserted-by":"crossref","first-page":"H380","DOI":"10.1152\/ajpheart.2002.282.1.H380","article-title":"Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL\/6 mice","volume":"282","author":"Gros","year":"2002","journal-title":"Am. J. Physiol, Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib13","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/BF02374472","article-title":"The BBZ\/Wor rat: clinical characteristics of the diabetic syndrome","volume":"36","author":"Guberski","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2007.10.028_bib14","first-page":"218","article-title":"Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle","volume":"246","author":"Ignarro","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.10.028_bib15","doi-asserted-by":"crossref","first-page":"S227","DOI":"10.1097\/01.ASN.0000077407.90309.65","article-title":"Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase","volume":"14","author":"Inoguchi","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1167\/iovs.05-1012","article-title":"Myogenic tone and reactivity of rat ophthalmic artery in acute exposure to high glucose and in a type II diabetic model","volume":"47","author":"Ito","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2007.10.028_bib17","doi-asserted-by":"crossref","first-page":"H2234","DOI":"10.1152\/ajpheart.00624.2002","article-title":"Role of phospholipase C in development of myogenic tone in rat posterior cerebral arteries","volume":"283","author":"Jarajapu","year":"2002","journal-title":"Am. J. Physiol, Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejphar.2006.07.036","article-title":"Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP","volume":"547","author":"Jarajapu","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib19","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.RES.59.5.483","article-title":"Autoregulation of blood flow","volume":"59","author":"Johnson","year":"1986","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3132\/dvdr.2007.001","article-title":"The insulin resistance syndrome: physiological considerations","volume":"4","author":"Kashyap","year":"2007","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib21","first-page":"S77","article-title":"Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C","volume":"60","author":"King","year":"1997","journal-title":"Kidney Inter., Suppl."},{"key":"10.1016\/j.ejphar.2007.10.028_bib22","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0022-3565(24)34971-7","article-title":"Heterogeneity of endothelium-dependent vasodilation in pressurized cerebral and small mesenteric resistance arteries of the rat","volume":"290","author":"Lagaud","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.10.028_bib23","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1159\/000051094","article-title":"Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries","volume":"38","author":"Lagaud","year":"2001","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib24","doi-asserted-by":"crossref","first-page":"C659","DOI":"10.1152\/ajpcell.1994.267.3.C659","article-title":"Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action","volume":"267","author":"Lee","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib25","doi-asserted-by":"crossref","first-page":"R586","DOI":"10.1152\/ajpregu.00612.2003","article-title":"Effects of age on brachial artery myogenic responses in humans","volume":"287","author":"Lott","year":"2004","journal-title":"Am. J. Physiol., Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cnur.2006.11.001","article-title":"A cascade of events \u2014 obesity, metabolic syndrome, and type 2 diabetes mellitus in youth","volume":"42","author":"McGillis Bindler","year":"2007","journal-title":"Nurs. Clin. North Am."},{"key":"10.1016\/j.ejphar.2007.10.028_bib27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/ilar.45.3.278","article-title":"Rat models of type 1 diabetes: genetics, environment, and autoimmunity","volume":"45","author":"Mordes","year":"2004","journal-title":"ILAR J."},{"key":"10.1016\/j.ejphar.2007.10.028_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0006-291X(89)91981-5","article-title":"Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction","volume":"162","author":"Muller-Decker","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2007.10.028_bib29","doi-asserted-by":"crossref","first-page":"H1662","DOI":"10.1152\/ajpheart.00004.2002","article-title":"Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles","volume":"283","author":"Muller-Delp","year":"2002","journal-title":"Am. J. Physiol, Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib30","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1161\/01.CIR.0000094403.78467.C3","article-title":"Physiology and pathophysiology of vascular signaling controlled by guanosine 3\u2032,5\u2032-cyclic monophosphate-dependent protein kinase [corrected]","volume":"108","author":"Munzel","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2007.10.028_bib31","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0014-4835(90)90056-Z","article-title":"The level of spontaneous myogenic tone in isolated human posterior ciliary arteries decreases with age","volume":"51","author":"Nyborg","year":"1990","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib32","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/01.HYP.31.5.1047","article-title":"Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction","volume":"31","author":"Pieper","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2007.10.028_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/01.STR.21.2.305","article-title":"Histamine elicits competing endothelium-dependent constriction and endothelium-independent dilation in vivo in mouse cerebral arterioles","volume":"21","author":"Rosenblum","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2007.10.028_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0165-6147(00)01775-2","article-title":"Protein kinases: tuners of the BKCa channel in smooth muscle","volume":"22","author":"Schubert","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2007.10.028_bib35","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s001250051376","article-title":"A comparison of diabetic polyneuropathy in type II diabetic BBZDR\/Wor rats and in type I diabetic BB\/Wor rats","volume":"43","author":"Sima","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2007.10.028_bib36","first-page":"688","article-title":"Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness","volume":"253","author":"Smith","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2007.10.028_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0008-6363(01)00193-6","article-title":"Effect of age on electrical field stimulation (EFS)-induced endothelium-dependent vasodilation in male and female rats","volume":"50","author":"Sullivan","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib38","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/ilar.45.3.292","article-title":"The BBZDR\/Wor rat model for investigating the complications of type 2 diabetes mellitus","volume":"45","author":"Tirabassi","year":"2004","journal-title":"ILAR J."},{"key":"10.1016\/j.ejphar.2007.10.028_bib39","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0008-6363(99)00106-6","article-title":"Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C","volume":"43","author":"Ungvari","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2007.10.028_bib40","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1210\/en.136.12.5709","article-title":"Reduction of penile nitric oxide synthase in diabetic BB\/WORdp (type I) and BBZ\/WORdp (type II) rats with erectile dysfunction","volume":"136","author":"Vernet","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2007.10.028_bib41","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1152\/japplphysiol.01073.2002","article-title":"Selected contribution: aging impairs nitric oxide and prostacyclin mediation of endothelium-dependent dilation in soleus feed arteries","volume":"95","author":"Woodman","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2007.10.028_bib42","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.RES.81.6.996","article-title":"Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats","volume":"81","author":"Zimmermann","year":"1997","journal-title":"Circ. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907011843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907011843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T22:51:00Z","timestamp":1737499860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907011843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":42,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0014299907011843"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.10.028","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}