{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:17:00Z","timestamp":1790756220600,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.ejphar.2007.12.014","type":"journal-article","created":{"date-parts":[[2007,12,28]],"date-time":"2007-12-28T15:51:33Z","timestamp":1198857093000},"page":"12-16","source":"Crossref","is-referenced-by-count":18,"title":["Inhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom"],"prefix":"10.1016","volume":"582","author":[{"given":"Meichun","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2007.12.014_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/mol.105.015941","article-title":"Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes","volume":"69","author":"Bosmans","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.12.014_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/mol.62.1.48","article-title":"Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies","volume":"62","author":"Escoubas","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.12.014_bib5","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1098\/rstb.1998.0319","article-title":"Why are there so few resistance-associated mutations in insecticide target genes?","volume":"353","author":"French-Constant","year":"1998","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"10.1016\/j.ejphar.2007.12.014_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/jn.1995.73.1.160","article-title":"Separation and identification of multiple potassium currents regulating the pacemaker activity of insect neurosecretory cells (DUM neurons)","volume":"73","author":"Grolleau","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2007.12.014_bib7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1152\/jn.1996.76.2.963","article-title":"Two distincts low-voltage-activated Ca2+ currents contribute to the pacemaker mechanism in cockroach dorsal unpaired median neurons.","volume":"76","author":"Grolleau","year":"1996","journal-title":"J. Neurophysiol."},{"issue":"11","key":"10.1016\/j.ejphar.2007.12.014_bib8","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1242\/jeb.203.11.1633","article-title":"Dorsal unpaired median neurones in the insect central nervous system: towards a better understanding of the ionic mechanisms underlying spontaneous electrical activity","volume":"203","author":"Grolleau","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ejphar.2007.12.014_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.toxicon.2006.11.012","article-title":"Modulation of insect Cav channels by peptidic spider toxins","volume":"49","author":"King","year":"2007","journal-title":"Toxicon."},{"key":"10.1016\/j.ejphar.2007.12.014_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/sj.bjp.0703853","article-title":"Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels","volume":"132","author":"Lapied","year":"2001","journal-title":"British. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2007.12.014_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.toxicon.2004.02.005","article-title":"An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)]","volume":"43","author":"Liang","year":"2004","journal-title":"Toxicon."},{"key":"10.1016\/j.ejphar.2007.12.014_bib12","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1073\/pnas.86.5.1689","article-title":"Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel web spider poison","volume":"86","author":"Linfis","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2007.12.014_bib13","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1074\/jbc.M513542200","article-title":"Function and solution structure of huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena.","volume":"281","author":"Liu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.12.014_bib14","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1432-1327.1999.00726.x","article-title":"Isolation, amino acid sequence and functional assays of SGTx1. The first toxin purified from the venom of the spider Scodra griseipes","volume":"265","author":"Marvin","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejphar.2007.12.014_bib15","doi-asserted-by":"crossref","first-page":"13373","DOI":"10.1073\/pnas.231376298","article-title":"Distinct potassium channels on pain-sensing neurons","volume":"98","author":"Matthew","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2007.12.014_bib16","doi-asserted-by":"crossref","first-page":"14734","DOI":"10.1021\/bi026546a","article-title":"Two tarantula peptides inhibit activation of multiple sodium channels","volume":"41","author":"Middleton","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2007.12.014_bib17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/355827a0","article-title":"P-type calcium channels blocked by the spider toxin omega-Aga-IVA","volume":"355","author":"Mintz","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2007.12.014_bib18","doi-asserted-by":"crossref","first-page":"15353","DOI":"10.1021\/bi981255g","article-title":"Selective peptide antagonist of class E Ca2+ channel from venom of the tarantula Hysterocrates gigas","volume":"37","author":"Newcomb","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2007.12.014_bib19","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/316440a0","article-title":"Three types of neuronal calcium channels with different calcium agonist sensitivity","volume":"316","author":"Nowicky","year":"1985","journal-title":"Nature (London),"},{"key":"10.1016\/j.ejphar.2007.12.014_bib20","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1021\/bi00317a001","article-title":"Purification and sequence of a presynaptic peptide toxin from Conus geographus venom","volume":"23","author":"Olivera","year":"1984","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2007.12.014_bib21","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.4071055","article-title":"Peptide neurotoxins from fish-hunting cone snails","volume":"230","author":"Olivera","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2007.12.014_bib22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0896-6273(95)90184-1","article-title":"An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula","volume":"15","author":"Swartz","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2007.12.014_bib23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.toxicon.2004.02.010","article-title":"Australian funnel-web spiders: master insecticide chemists","volume":"43","author":"Tedford","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2007.12.014_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.7832825","article-title":"Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission","volume":"264","author":"Wheeler","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2007.12.014_bib25","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00001756-199405000-00001","article-title":"Ca2+ currents in cockroach neurones: properties and modulation by neurohormone D","volume":"5","author":"Wicher","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2007.12.014_bib26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/jn.1997.77.1.186","article-title":"Ca2+ currents in central insect neurons: electrophysiological and pharmacological properties","volume":"77","author":"Wicher","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2007.12.014_bib27","doi-asserted-by":"crossref","first-page":"12069","DOI":"10.1074\/jbc.M411651200","article-title":"Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation","volume":"280","author":"Xiao","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2007.12.014_bib28","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0028-3908(93)90003-L","article-title":"Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS-neurons","volume":"32","author":"Zhang","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2007.12.014_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0041-0101(03)00095-3","article-title":"Huwentoxin-V, a novel insecticidal peptide toxin from the spider Selenocosmia huwena, and a natural mutant of the toxin: indicates the key amino acid residues related to the biological activity","volume":"42","author":"Zhang","year":"2003","journal-title":"Toxicon"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907013519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299907013519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:47:29Z","timestamp":1630406849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299907013519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":27,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0014299907013519"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2007.12.014","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}