{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:39:51Z","timestamp":1791301191285,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.ejphar.2008.01.025","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T13:44:33Z","timestamp":1202305473000},"page":"73-83","source":"Crossref","is-referenced-by-count":79,"title":["Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry"],"prefix":"10.1016","volume":"583","author":[{"given":"Laxmikant S.","family":"Deshpande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey K.","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sompong","family":"Sombati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Attkisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"DeLorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2008.01.025_bib1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0896-6273(90)90053-I","article-title":"Excitotoxicity induced by enhanced excitatory neurotransmission in cultured hippocampal pyramidal neurons","volume":"4","author":"Abele","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2008.01.025_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00001756-200503150-00017","article-title":"Proteolysis of NR2B by calpain in the hippocampus of epileptic rats","volume":"16","author":"Araujo","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2008.01.025_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0306-4522(03)00027-7","article-title":"N-methyl-d-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy","volume":"118","author":"Brandt","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2008.01.025_bib4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1600-0404.1992.tb05123.x","article-title":"Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats","volume":"86","author":"Bruhn","year":"1992","journal-title":"Acta. Neurol. Scand."},{"key":"10.1016\/j.ejphar.2008.01.025_bib5","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1111\/j.1471-4159.2006.03991.x","article-title":"The chemical biology of clinically tolerated NMDA receptor antagonists","volume":"97","author":"Chen","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2008.01.025_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1523\/JNEUROSCI.07-02-00357.1987","article-title":"Glutamate neurotoxicity in cortical cell culture","volume":"7","author":"Choi","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2008.01.025_bib7","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.neuropharm.2007.01.010","article-title":"Upregulation of nitric oxide synthase II contributes to apoptotic cell death in the hippocampal CA3 subfield via a cytochrome c\/caspase-3 signaling cascade following induction of experimental temporal lobe status epilepticus in the rat","volume":"52","author":"Chuang","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2008.01.025_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0197-0186(95)00149-2","article-title":"Nitric oxide actions in neurochemistry","volume":"29","author":"Dawson","year":"1996","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2008.01.025_bib9","first-page":"199","article-title":"Epidemiology and clinical presentation of status epilepticus","volume":"97","author":"Delorenzo","year":"2006","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib10","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1073\/pnas.95.24.14482","article-title":"Prolonged activation of the N-methyl-d-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture","volume":"95","author":"DeLorenzo","year":"1998","journal-title":"Proc. Natal. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2008.01.025_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1528-1157.1999.tb02070.x","article-title":"Comparison of status epilepticus with prolonged seizure episodes lasting from 10 to 29\u00a0minutes","volume":"40","author":"DeLorenzo","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pharmthera.2004.10.004","article-title":"Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy","volume":"105","author":"Delorenzo","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2008.01.025_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2006.11.030","article-title":"Endocannabinoids block status epilepticus in cultured hippocampal neurons","volume":"558","author":"Deshpande","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1124\/jpet.107.123182","article-title":"Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury","volume":"322","author":"Deshpande","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2008.01.025_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.eplepsyres.2007.05.011","article-title":"In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons","volume":"75","author":"Deshpande","year":"2007","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jnr.490270105","article-title":"Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells","volume":"27","author":"Didier","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/ebeh.2000.0100","article-title":"Presentation, evaluation, and treatment of nonconvulsive status epilepticus","volume":"1","author":"Drislane","year":"2000","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2008.01.025_bib18","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1212\/WNL.59.9_suppl_5.S15","article-title":"Seizure-induced neuronal injury: human data","volume":"59","author":"Duncan","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2008.01.025_bib19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.nbd.2003.08.022","article-title":"Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival","volume":"14","author":"Ekdahl","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2008.01.025_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00401-003-0733-y","article-title":"Distribution of alpha and beta integrin subunits in the adult rat hippocampus after pilocarpine-induced neuronal cell loss, axonal reorganization and reactive astrogliosis","volume":"106","author":"Fasen","year":"2003","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.ejphar.2008.01.025_bib21","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1111\/j.1528-1157.2000.tb01521.x","article-title":"Status epilepticus: risk factors and complications","volume":"2","author":"Fountain","year":"2000","journal-title":"Epilepsia 41 Suppl"},{"key":"10.1016\/j.ejphar.2008.01.025_bib22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/jnen\/62.7.733","article-title":"GluR2(B) knockdown accelerates CA3 injury after kainate seizures","volume":"62","author":"Friedman","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yebeh.2005.08.003","article-title":"Prolonged seizures and cellular injury: understanding the connection","volume":"7","author":"Fujikawa","year":"2005","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2008.01.025_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0920-1211(94)90051-5","article-title":"The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage","volume":"17","author":"Fujikawa","year":"1994","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib25","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1528-1157.2000.tb00283.x","article-title":"Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy","volume":"41","author":"Fujikawa","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib26","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1523\/JNEUROSCI.0900-05.2005","article-title":"Status epilepticus increases the intracellular accumulation of GABAA receptors","volume":"25","author":"Goodkin","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2008.01.025_bib27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1046\/j.1528-1157.2003.53902.x","article-title":"Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures","volume":"44","author":"Gorter","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2008.01.025_bib29","first-page":"3","article-title":"Status epilepticus: frequency, etiology, and neurological sequelae","volume":"34","author":"Hauser","year":"1983","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib30","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1212\/WNL.59.9_suppl_5.S3","article-title":"Seizure-induced neuronal injury: animal data","volume":"59","author":"Holmes","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2008.01.025_bib31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2174\/0929867013372328","article-title":"The NMDA receptor complex: a promising target for novel antiepileptic strategies","volume":"8","author":"Kohl","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2008.01.025_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(95)00552-2","article-title":"Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death","volume":"690","author":"Limbrick","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib33","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","article-title":"Ischemic cell death in brain neurons","volume":"79","author":"Lipton","year":"1999","journal-title":"Physiol.Rev."},{"key":"10.1016\/j.ejphar.2008.01.025_bib34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0014-4886(03)00207-3","article-title":"Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid level","volume":"184","author":"Liu","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib35","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/j.1528-1167.2005.51603.x","article-title":"Cerebral damage in epilepsy: a population-based longitudinal quantitative MRI study","volume":"46","author":"Liu","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib36","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.bjp.0705111","article-title":"Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture","volume":"138","author":"Lopez","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(91)90011-O","article-title":"Functional anatomy of hippocampal seizures","volume":"37","author":"Lothman","year":"1991","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib38","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1056\/NEJM199804023381407","article-title":"Status epilepticus","volume":"338","author":"Lowenstein","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2008.01.025_bib39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1528-1157.1999.tb02000.x","article-title":"It's time to revise the definition of status epilepticus","volume":"40","author":"Lowenstein","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib40","doi-asserted-by":"crossref","first-page":"8005","DOI":"10.1523\/JNEUROSCI.20-21-08005.2000","article-title":"NMDA but not non-NMDA excitotoxicity is mediated by poly(ADP-ribose) polymerase","volume":"20","author":"Mandir","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2008.01.025_bib41","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1152\/jn.00547.2003","article-title":"Factors underlying bursting behavior in a network of cultured hippocampal neurons exposed to zero magnesium","volume":"91","author":"Mangan","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1113\/jphysiol.1984.sp015360","article-title":"Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp","volume":"354","author":"Mayer","year":"1984","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0920-1211(91)90095-W","article-title":"Excitotoxicity and epileptic brain damage","volume":"10","author":"Meldrum","year":"1991","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archneur.1973.00490260026003","article-title":"Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed, artificially ventilated baboons","volume":"29","author":"Meldrum","year":"1973","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib45","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1528-1157.2003.22502.x","article-title":"Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms","volume":"44","author":"Mikati","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0920-1211(93)90018-3","article-title":"Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures","volume":"14","author":"Millan","year":"1993","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib47","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/jn.1987.57.3.869","article-title":"Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices","volume":"57","author":"Mody","year":"1987","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib48","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0074-7742(08)60561-9","article-title":"Excitatory transmitters and epilepsy-related brain damage","volume":"27","author":"Olney","year":"1985","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib49","first-page":"533","article-title":"Neurotoxicity of NMDA receptor antagonists: an overview","volume":"30","author":"Olney","year":"1994","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.ejphar.2008.01.025_bib50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0361-9230(83)90038-2","article-title":"\u201cEpileptic\u201d brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology","volume":"10","author":"Olney","year":"1983","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2008.01.025_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0165-3806(89)90075-8","article-title":"Development of N-methyl-d-aspartate excitotoxicity in cultured hippocampal neurons","volume":"48","author":"Peterson","year":"1989","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0079-6123(02)35008-8","article-title":"Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy","volume":"135","author":"Pitkanen","year":"2002","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0006-8993(97)01285-7","article-title":"NMDA receptor activation during status epilepticus is required for the development of epilepsy","volume":"782","author":"Rice","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1523\/JNEUROSCI.20-01-00022.2000","article-title":"Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity","volume":"20","author":"Sattler","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2008.01.025_bib55","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0361-9230(83)90037-0","article-title":"\u201cEpileptic\u201d brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies","volume":"10","author":"Sloviter","year":"1983","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2008.01.025_bib56","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/sj.bjp.0701231","article-title":"NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis","volume":"121","author":"Smolders","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib57","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1152\/jn.1995.73.4.1706","article-title":"Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture","volume":"73","author":"Sombati","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2008.01.025_bib58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ceca.2003.09.003","article-title":"Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy","volume":"35","author":"Sun","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2008.01.025_bib59","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0079-6123(02)35013-1","article-title":"Summary: seizure-induced damage in experimental models","volume":"135","author":"Sutula","year":"2002","journal-title":"Prog Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0006-8993(96)00658-0","article-title":"The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats","volume":"737","author":"Tanaka","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib61","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/brain\/awh475","article-title":"Quantitative post-mortem study of the hippocampus in chronic epilepsy: seizures do not inevitably cause neuronal loss","volume":"128","author":"Thom","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2008.01.025_bib62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1528-1157.1994.tb02908.x","article-title":"Determinants of mortality in status epilepticus","volume":"35","author":"Towne","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2008.01.025_bib63","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJM199809173391202","article-title":"A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group","volume":"339","author":"Treiman","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2008.01.025_bib64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00221-002-1224-4","article-title":"Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus","volume":"147","author":"Ueda","year":"2002","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ejphar.2008.01.025_bib65","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0920-1211(96)00057-5","article-title":"Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy","volume":"26","author":"Wilson","year":"1996","journal-title":"Epilepsy Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299908000940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299908000940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T18:52:09Z","timestamp":1557255129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299908000940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0014299908000940"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2008.01.025","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}