{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:02:02Z","timestamp":1786633322012,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.ejphar.2008.06.032","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T15:05:29Z","timestamp":1213369529000},"page":"224-232","source":"Crossref","is-referenced-by-count":32,"title":["Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist"],"prefix":"10.1016","volume":"590","author":[{"given":"Ildiko","family":"Antal-Zimanyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc. A.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"LeBoulluec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence G.","family":"Iben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail K.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel T.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Leahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon C.","family":"Flowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid A.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham S.","family":"Poindexter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2008.06.032_bib1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.peptides.2006.08.041","article-title":"Neuropeptide Y (NEUROPEPTIDE Y) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: combined anorectic effects of Y2 and Y4 receptor-selective agonists","volume":"28","author":"Balasubramaniam","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1359\/jbmr.060705","article-title":"Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways","volume":"21","author":"Baldock","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2008.06.032_bib3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1517\/14656566.1.4.841","article-title":"Orlistat in the treatment of obesity","volume":"1","author":"Ballinger","year":"2000","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.ejphar.2008.06.032_bib4","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1124\/mol.106.033118","article-title":"Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects","volume":"71","author":"Bifulco","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.06.032_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1467-789X.2005.00218.x","article-title":"PYY3-36 as an anti-obesity drug target","volume":"6","author":"Boggiano","year":"2005","journal-title":"Obes. Rev."},{"key":"10.1016\/j.ejphar.2008.06.032_bib6","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/sj.bjp.0704030","article-title":"Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y","volume":"132","author":"Brown","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.06.032_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0006-8993(87)90055-2","article-title":"Adrenergic receptor and catecholamine distribution in rat cerebral cortex: binding studies with [3H]prazosin, [3H]idazoxan and [3H]dihydroalprenolol","volume":"402","author":"Diop","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2008.06.032_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3181\/00379727-218-44263","article-title":"Multiple receptors for the pancreatic polypeptide (PP-Fold) family: physiological implications","volume":"218","author":"Gehlert","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2008.06.032_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.npep.2004.07.002","article-title":"Introduction to the reviews on neuropeptide Y","volume":"38","author":"Gehlert","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.bjp.0700883","article-title":"Characterization of Y3 receptor-mediated synaptic inhibition by chimeric neuropeptide Y-peptide YY peptides in the rat brainstem","volume":"120","author":"Glaum","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.06.032_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.npep.2004.05.002","article-title":"The neuropeptide Y system in stress, anxiety and depression","volume":"38","author":"Heilig","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1463-1326.2004.00312.x","article-title":"Role of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression","volume":"6","author":"Huang","year":"2004","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ejphar.2008.06.032_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/sj.clpt.6100169","article-title":"Obesity pharmacotherapy from a regulatory perspective: overview and key challenges","volume":"81","author":"Hutchinson","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2008.06.032_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00213-004-1916-5","article-title":"Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist","volume":"177","author":"Jarbe","year":"2004","journal-title":"Psychopharmacol."},{"key":"10.1016\/j.ejphar.2008.06.032_bib15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0952-3278(97)90559-7","article-title":"Arachidonylethanolamide (anadamide) binds with low affinity to dihydropyridine binding sites in brain membrane","volume":"57","author":"Jarrahian","year":"1997","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.ejphar.2008.06.032_bib16","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1210\/en.137.8.3177","article-title":"Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake","volume":"137","author":"Kanatani","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2008.06.032_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/bbrc.1999.1750","article-title":"The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability","volume":"266","author":"Kanatani","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2008.06.032_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-0115(98)00076-7","article-title":"Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats","volume":"75\u201376","author":"Kask","year":"1998","journal-title":"Reg. Peptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.peptides.2006.09.024","article-title":"A role for pancreatic polypeptide in feeding and body weight regulation","volume":"28","author":"Kojima","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib20","first-page":"743","article-title":"Evolution of neuropeptide Y and its related peptides","volume":"106","author":"Larhammar","year":"1993","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.ejphar.2008.06.032_bib21","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0361-9230(88)90025-1","article-title":"Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: stimulation of feeding and the release of corticosterone, vasopressin and glucose","volume":"21","author":"Leibowitz","year":"1988","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2008.06.032_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.npep.2004.05.005","article-title":"Neuropeptide Y and Y receptors: Lessons from transgenic and knockout models","volume":"38","author":"Lin","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib23","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1210\/en.2006-0097","article-title":"Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity","volume":"147","author":"Lin","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2008.06.032_bib24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nm0698-718","article-title":"Role of the Y5 neuropeptide Y receptor in feeding and obesity","volume":"4","author":"Marsh","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2008.06.032_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0167-0115(98)00091-3","article-title":"The neuropeptide Y Y1 receptor antagonist BIBP 3226 blocks neuropeptide Y induced feeding via a non-specific mechanism","volume":"75\u201376","author":"Morgan","year":"1998","journal-title":"Reg. Peptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2004.02.006","article-title":"Peptides and obesity: the PYY3-36 story","volume":"119","author":"Park","year":"2004","journal-title":"Re. Peptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.npep.2004.05.007","article-title":"Importance of neuropeptide Y Y1 receptor-mediated pathways: assessment using neuropeptide Y Y1 receptor knockouts","volume":"38","author":"Pedrazzini","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib28","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nm0698-722","article-title":"Cardiovascular response, feeding behavior and locomotor activity in mice lacking the neuropeptide Y Y1 receptor","volume":"4","author":"Pedrazzini","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2008.06.032_bib29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bmc.2003.10.016","article-title":"Dihydropyridine neuropeptide Y Y1 receptor antagonists 2. bioisosteric urea replacements","volume":"12","author":"Poindexter","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2008.06.032_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0960-894X(01)00761-2","article-title":"Dihydropyridine neuropeptide Y Y(1) receptor antagonists","volume":"12","author":"Poindexter","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2008.06.032_bib31","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1074\/jbc.272.6.3622","article-title":"Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine \u201cY5\u201d receptor may be a pseudogene","volume":"272","author":"Rose","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2008.06.032_bib32","doi-asserted-by":"crossref","first-page":"8938","DOI":"10.1073\/pnas.132043299","article-title":"Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice","volume":"99","author":"Sainsbury","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2008.06.032_bib33","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1128\/MCB.23.15.5225-5233.2003","article-title":"Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice","volume":"23","author":"Sainsbury","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2008.06.032_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2337\/diabetes.55.01.06.db05-0472","article-title":"Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice","volume":"55","author":"Sainsbury","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2008.06.032_bib35","doi-asserted-by":"crossref","first-page":"E1062","DOI":"10.1152\/ajpendo.00450.2006","article-title":"Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects","volume":"292","author":"Sloth","year":"2007","journal-title":"Am. J. Physiol: Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2008.06.032_bib36","first-page":"143","article-title":"Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226","volume":"275","author":"Wieland","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2008.06.032_bib37","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/sj.bjp.0702084","article-title":"Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents","volume":"125","author":"Wieland","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2008.06.032_bib38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.npep.2004.07.001","article-title":"Neuropeptide Y and seizures: effects of exogenously applied ligands","volume":"38","author":"Woldbye","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2008.06.032_bib39","first-page":"1307","article-title":"Obesity drug sibutramine (Meridia): hypertension and cardiac arrhythmias","volume":"166","author":"Wooltorton","year":"2002","journal-title":"Can. Med. Assoc. J."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990800650X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990800650X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T22:52:06Z","timestamp":1545951126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429990800650X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":39,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S001429990800650X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2008.06.032","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}