{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:41:29Z","timestamp":1773211289340,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.ejphar.2009.01.043","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T20:09:56Z","timestamp":1234382996000},"page":"102-108","source":"Crossref","is-referenced-by-count":12,"title":["Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models"],"prefix":"10.1016","volume":"606","author":[{"given":"Satoru","family":"Yoshikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Hareyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2009.01.043_bib1","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1523\/JNEUROSCI.18-14-05545.1998","article-title":"Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine","volume":"18","author":"Adams","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib2","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1073\/pnas.92.11.5062","article-title":"The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids","volume":"92","author":"Arvidsson","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2009.01.043_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjp.0706782","article-title":"Presynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex","volume":"148","author":"Berger","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1176\/ajp.135.2.164","article-title":"Antipsychotic drugs, neurotransmitters, and schizophrenia","volume":"135","author":"Carlsson","year":"1978","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2009.01.043_bib5","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/sj.npp.1300678","article-title":"Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonist","volume":"30","author":"Chrtoff","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2009.01.043_bib6","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1055\/s-2007-992133","article-title":"Dopamine and serotonin interactions in the prefrontal cortex: insights on antipsychotic drugs and their mechanism of action","volume":"40","author":"Di Pietro","year":"2007","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.ejphar.2009.01.043_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0022-3565(25)39097-X","article-title":"Kappa opioids in rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects","volume":"242","author":"Dykstra","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.01.043_bib8","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0024-3205(99)00417-8","article-title":"Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist","volume":"65","author":"Endoh","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib9","first-page":"30","article-title":"Nor-binaltorphimine: a potent and selective kappa-opioid receptor antagonist with long-lasting activity in vivo","volume":"316","author":"Endoh","year":"1992","journal-title":"Arch Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.ejphar.2009.01.043_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0091-3057(98)00128-2","article-title":"Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex","volume":"61","author":"Etou","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2009.01.043_bib11","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0028-3908(02)00029-1","article-title":"Behavioral arousal and increased dopamine efflux after blockade of NMDA-receptors in the prefrontal cortex are dependent on activation of glutamatergic neurotransmission","volume":"42","author":"Feenstra","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2009.01.043_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1570159052773387","article-title":"Glycine site modulators and glycine transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia","volume":"3","author":"Gene","year":"2005","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib13","series-title":"Psychopharmacology: The Fifth Generation of Progress","article-title":"Animal models relevant to schizophrenia disorder","author":"Geyer","year":"2002"},{"key":"10.1016\/j.ejphar.2009.01.043_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s002130050165","article-title":"Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice","volume":"129","author":"Gleason","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2009.01.043_bib15","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1196\/annals.1316.050","article-title":"Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence","volume":"1025","author":"Hasebe","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0006-8993(87)91588-5","article-title":"Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons","volume":"435","author":"Herv\u00e9","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.01.043_bib17","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1523\/JNEUROSCI.2213-07.2007","article-title":"NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons","volume":"24","author":"Homayoun","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-8993(94)91558-X","article-title":"Effect of phencyclidine on dopamine release in the rat prefrontal cortex; an in vivo microdialysis study","volume":"633","author":"Hondo","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.01.043_bib19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s002130050649","article-title":"Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence","volume":"138","author":"Jentsch","year":"1998","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2009.01.043_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1254\/jjp.66.181","article-title":"Effects of risperidone on phencyclidine-induced behaviors: comparison with haloperidol and ritanserin","volume":"66","author":"Kitaichi","year":"1994","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-2999(97)01557-4","article-title":"Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin","volume":"343","author":"Krebs-Thomson","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib22","series-title":"Itch\/Basic Mechanisms and Therapy","first-page":"279","article-title":"Prospects for a novel \u03ba-opioid receptor agonist, TRK-820, in uremic pruritus","author":"Kumagai","year":"2004"},{"key":"10.1016\/j.ejphar.2009.01.043_bib23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0306-4522(95)00464-5","article-title":"Immunohistochemical localization of the cloned kappa 1 receptor in the rat CNS and pituitary","volume":"71","author":"Mansour","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2009.01.043_bib24","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1152\/jn.00855.2004","article-title":"Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons","volume":"93","author":"Margolis","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib25","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1073\/pnas.0511159103","article-title":"Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex","volume":"103","author":"Margolis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2009.01.043_bib26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0022-3565(25)11209-3","article-title":"Behavioral disinhibition and depression in amphetaminized rats: a comparison of risperidone, ocaperidone and haloperidol","volume":"260","author":"Megens","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.01.043_bib27","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1046\/j.1460-9568.1999.00858.x","article-title":"Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2A sites for PCP-induced locomotion in the rat","volume":"11","author":"Millan","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0006-3223(99)00078-5","article-title":"The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia","volume":"46","author":"Moore","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2009.01.043_bib29","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.lfs.2004.05.017","article-title":"Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats","volume":"75","author":"Mori","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1254\/jphs.SCJ05006X","article-title":"Generalization of NMDA-receptor antagonists to the discriminative stimulus effects of kappa-opioid receptor agonists U-50,488H, but not TRK-820 in rats","volume":"100","author":"Mori","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-2999(85)90550-3","article-title":"Acute and chronic phencyclidine administration changes serotonin receptors in rat brain","volume":"109","author":"Nabeshima","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0091-3057(84)80102-1","article-title":"Serotonergic involvement in phencyclidine-induced behaviors","volume":"21","author":"Nabeshima","year":"1984","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2009.01.043_bib33","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0022-3565(25)39280-3","article-title":"Potentiation in phencyclidine-induced serotonin-mediated behaviors after intracerebroventricular administration of 5,7-dihydroxytryptamine in rats","volume":"243","author":"Nabeshima","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.01.043_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1248\/cpb.46.366","article-title":"Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan","volume":"46","author":"Nagase","year":"1998","journal-title":"Chem. Pharm. Bull. (Tokyo),"},{"key":"10.1016\/j.ejphar.2009.01.043_bib35","first-page":"75","article-title":"Effect of TRK-820, a selective \u03ba opioid receptor agonist, on scratching behavior in an animal model of atopic dermatitis","volume":"28","author":"Nakao","year":"2008","journal-title":"Jpn. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0893-133X(00)00138-X","article-title":"Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions","volume":"23","author":"Noda","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2009.01.043_bib37","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1471-4159.2004.02358.x","article-title":"NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR","volume":"89","author":"Olszewski","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2009.01.043_bib38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0006-8993(87)91628-3","article-title":"Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats","volume":"435","author":"O'Neill","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.01.043_bib39","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1126\/science.3016896","article-title":"Psychotomimesis mediated by kappa opiate receptors","volume":"233","author":"Pfeiffer","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2009.01.043_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00192549","article-title":"The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist","volume":"46","author":"Rimoy","year":"1994","journal-title":"Eur. J. Clin. Pharmacol.,"},{"key":"10.1016\/j.ejphar.2009.01.043_bib41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0893-133X(01)00268-8","article-title":"Gamma vinyl-GABA differentially modulates NMDA antagonist-induced increases in mesocortical versus mesolimbic DA transmission","volume":"25","author":"Schiffer","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2009.01.043_bib42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejphar.2007.02.031","article-title":"Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT 2A\/2C receptors","volume":"564","author":"Su","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2003.09.057","article-title":"Effect of repeated administration of TRK-820, a kappa-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions","volume":"995","author":"Suzuki","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.01.043_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-2999(01)01254-7","article-title":"MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain","volume":"427","author":"Takahashi","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s002130051061","article-title":"Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors","volume":"145","author":"Takahashi","year":"1999","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2009.01.043_bib46","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.npp.1300127","article-title":"Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine","volume":"28","author":"Takahata","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2009.01.043_bib47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0022-3565(25)21011-4","article-title":"Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays","volume":"246","author":"Takemori","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.01.043_bib48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2005.04.076","article-title":"mu-Opioids disinhibit and kappa-opioids inhibit serotonin efflux in the dorsal raphe nucleus","volume":"1049","author":"Tao","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.01.043_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1126\/science.182.4111.499","article-title":"Dopaminergic terminals in the rat cortex","volume":"182","author":"Thierry","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2009.01.043_bib50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0014-2999(01)01588-6","article-title":"Antipruritic activity of the kappa-opioid receptor agonist, TRK-820","volume":"435","author":"Togashi","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pharmtox.42.082701.160735","article-title":"Glutamatergic mechanisms in schizophrenia","volume":"42","author":"Tsai","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib52","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0024-3205(01)00957-2","article-title":"The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice","volume":"68","author":"Tsuji","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0024-3205(00)00582-8","article-title":"A novel kappa-opioid receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice","volume":"66","author":"Tsuji","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.01.043_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2003.08.007","article-title":"Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system","volume":"477","author":"Umeuchi","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib55","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1681\/ASN.2005020152","article-title":"Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies","volume":"16","author":"Wikstr\u00f6m","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2009.01.043_bib56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/cercor\/3.3.199","article-title":"Characterization of the dopaminergic innervation of the primate frontal cortex using a dopamine-specific antibody","volume":"3","author":"Williams","year":"1993","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.ejphar.2009.01.043_bib57","first-page":"479","article-title":"Potentiation of phencyclidine-induced dopamine-dependent behaviors in rats after pretreatments with serotonin-depletors","volume":"9","author":"Yamaguchi","year":"1986","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.ejphar.2009.01.043_bib58","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1248\/bpb1978.9.987","article-title":"Role of dopaminergic and serotonergic neuronal systems in the prefrontal cortex of rats in phencyclidine-induced behaviors","volume":"9","author":"Yamaguchi","year":"1986","journal-title":"J. Pharmacobiodyn."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909001162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909001162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T16:49:20Z","timestamp":1738946960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299909001162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":58,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0014299909001162"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2009.01.043","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}