{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:02:09Z","timestamp":1761058929567,"version":"3.37.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.ejphar.2009.04.042","type":"journal-article","created":{"date-parts":[[2009,5,5]],"date-time":"2009-05-05T08:35:06Z","timestamp":1241512506000},"page":"146-152","source":"Crossref","is-referenced-by-count":22,"title":["Does telmisartan prevent hepatic fibrosis in rats with alloxan-induced diabetes?"],"prefix":"10.1016","volume":"614","author":[{"given":"Zekai","family":"Halici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habip","family":"Bilen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Albayrak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Uyanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halis","family":"Suleyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman Nuri","family":"Keles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunyami","family":"Unal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2009.04.042_bib1","first-page":"270","article-title":"How to prevent complications of liver cirrhosis?","volume":"28","author":"Adler","year":"2007","journal-title":"Revue M\u00e9dicale de Bruxelles"},{"key":"10.1016\/j.ejphar.2009.04.042_bib2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1002\/dmrr.254","article-title":"Insulin resistance in type 2 diabetes: role of fatty acids","volume":"18","author":"Arner","year":"2002","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"10.1016\/j.ejphar.2009.04.042_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2362.1981.tb01844.x","article-title":"Effect of angiotensin-II blockade on systemic and hepatic haemodynamics and on the renin\u2013angiotensin\u2013aldosterone system in cirrhosis with ascites","volume":"11","author":"Arroyo","year":"1981","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1016\/j.ejphar.2009.04.042_bib4","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0016-5085(00)70368-4","article-title":"Angiotensin II induces contraction and proliferation of human hepatic stellate cells","volume":"118","author":"Bataller","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.HYP.0000123072.34629.57","article-title":"Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity","volume":"43","author":"Benson","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2009.04.042_bib6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1524-6175.2004.03750.x","article-title":"Analysis of recent papers in hypertension","volume":"6","author":"Bloch","year":"2004","journal-title":"Journal of Clinical Hypertension (Greenwich, Conn.)"},{"key":"10.1016\/j.ejphar.2009.04.042_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10739680701282986","article-title":"Obesity, insulin resistance and hepatic perfusion","volume":"14","author":"Brock","year":"2007","journal-title":"Microcirculation"},{"key":"10.1016\/j.ejphar.2009.04.042_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1172\/JCI112566","article-title":"Angiotensinogen gene is expressed and differentially regulated in multiple tissues of rat","volume":"78","author":"Campbell","year":"1986","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.ejphar.2009.04.042_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI112768","article-title":"Circulating and tissue angiotensin systems","volume":"79","author":"Campbelli","year":"1987","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.ejphar.2009.04.042_bib10","article-title":"Anti-inflammatory and anti-oxidant properties of telmisartan in cultured human umbilical vein endothelial cells","volume":"22","author":"Cianchetti","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2009.04.042_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1023\/A:1020714518246","article-title":"Angiotensin II and nitric oxide interactions","volume":"7","author":"De Gasparo","year":"2002","journal-title":"Heart Failure Reviews"},{"key":"10.1016\/j.ejphar.2009.04.042_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"The angiotensin II receptors","volume":"52","author":"De Gasparo","year":"2000","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.ejphar.2009.04.042_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/cne.20055","article-title":"Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: volume, neuron number, and cell types","volume":"472","author":"Dorph-Petersen","year":"2004","journal-title":"The Journal of Comparative Neurology"},{"issue":"II","key":"10.1016\/j.ejphar.2009.04.042_bib14","first-page":"100","article-title":"Molecular mechanisms of vascular renin\u2013angiotensin system in myointimal hyperplasia","volume":"18","author":"Dzau","year":"1991","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2009.04.042_bib15","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1172\/JCI119752","article-title":"Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin\/angiotensin II crosstalk","volume":"100","author":"Folli","year":"1997","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.ejphar.2009.04.042_bib16","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0016-5085(99)70413-0","article-title":"The virtuosity of hepatic stellate cells","volume":"117","author":"Friedman","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.ejphar.2009.04.042_bib18","first-page":"6","article-title":"Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options","volume":"30","author":"Gressner","year":"2007","journal-title":"Comparative Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib19","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2009.04.042_bib20","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1476-5926-2-S1-S48","article-title":"Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo","volume":"3","author":"Gujral","year":"2004","journal-title":"Comparative Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The efficiency of systematic sampling in stereology and its prediction","volume":"147","author":"Gundersen","year":"1987","journal-title":"Journal of Microscopy"},{"key":"10.1016\/j.ejphar.2009.04.042_bib22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology \u2014 reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"Journal of Microscopy"},{"key":"10.1016\/j.ejphar.2009.04.042_bib23","first-page":"1","article-title":"Prospects and perspectives of natural plant products in medicine","volume":"26","author":"Gupta","year":"1994","journal-title":"Indian Journal of Pharmacology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib24","series-title":"Unbiased stereology: three dimensional measurement in microscopy","first-page":"1","author":"Howard","year":"1998"},{"key":"10.1016\/j.ejphar.2009.04.042_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2818.2001.00931.x","article-title":"A simple technique to measure the movements of the microscope stage along the x and y axes for stereological methods","volume":"203","author":"Kaplan","year":"2001","journal-title":"Journal of Microscopy"},{"key":"10.1016\/j.ejphar.2009.04.042_bib26","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1097\/00004872-200412000-00003","article-title":"Antidiabetic mechanisms of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists: beyond the renin-angiotensin system","volume":"22","author":"Kurtz","year":"2004","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.ejphar.2009.04.042_bib27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1677\/jme.0.0260155","article-title":"Tissue renin\u2013angiotensin system: its expression, localization, regulation and potential role in the pancreas","volume":"26","author":"Leung","year":"2001","journal-title":"Journal of Molecular Endocrinology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0167-0115(00)00169-5","article-title":"Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis","volume":"96","author":"Leung","year":"2001","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.ejphar.2009.04.042_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1677\/joe.0.1670517","article-title":"Chronic hypoxia upregulates the expression and function of AT1 receptor in rat carotid body","volume":"167","author":"Leung","year":"2000","journal-title":"Journal of Endocrinology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0167-0115(03)00192-7","article-title":"Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response","volume":"116","author":"Leung","year":"2003","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.ejphar.2009.04.042_bib31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/002215540305100814","article-title":"A New approach to an unbiased estimate of the hepatic stellate cell index in the rat liver: an example in healthy conditions","volume":"51","author":"Marcos","year":"2003","journal-title":"The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society"},{"key":"10.1016\/j.ejphar.2009.04.042_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2818.1990.tb03036.x","article-title":"Estimation of surface area and length with the orientator","volume":"159","author":"Mattfeldt","year":"1990","journal-title":"Journal of Microscopy"},{"key":"10.1016\/j.ejphar.2009.04.042_bib33","series-title":"The liver: biology and pathobiology","first-page":"511","article-title":"Insulin and other growth factors","author":"Michael","year":"2001"},{"key":"10.1016\/j.ejphar.2009.04.042_bib34","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2337\/diacare.28.3.757","article-title":"Replacement of valsartan and candesartan by telmisartan in hypertensive patients with type 2 diabetes: metabolic and antiatherogenic consequences","volume":"28","author":"Miura","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2009.04.042_bib35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2818.1992.tb01497.x","article-title":"The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens","volume":"165","author":"Nyengaard","year":"1992","journal-title":"Journal of Microscopy"},{"key":"10.1016\/j.ejphar.2009.04.042_bib36","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.HYP.0000040262.48405.A8","article-title":"Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling","volume":"40","author":"Ogihara","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2009.04.042_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1386-6346(01)00102-4","article-title":"Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic arbontetrachloride-induced hepatic fibrosis in rats","volume":"21","author":"Ohishi","year":"2001","journal-title":"Hepatology Research: the Official Journal of the Japan Society of Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib38","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0168-8278(01)00146-5","article-title":"Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis","volume":"35","author":"Paizis","year":"2001","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/sj.jhh.1000434","article-title":"Losartan mediated improvement in insulin action is mainly due to an increase in non-oxidative glucose metabolism and blood flow in insulin-resistant hypertensive patients","volume":"11","author":"Paolisso","year":"1997","journal-title":"Journal of Human Hypertension"},{"key":"10.1016\/j.ejphar.2009.04.042_bib40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.visres.2007.09.019","article-title":"Nanoparticle-delivered biosensor for reactive oxygen species in diabetes","volume":"48","author":"Prow","year":"2008","journal-title":"Vision Research"},{"key":"10.1016\/j.ejphar.2009.04.042_bib41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hep.510240137","article-title":"Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance","volume":"24","author":"Rockey","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib42","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/hep.510270416","article-title":"(Latent) transforming growth factor beta in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells","volume":"27","author":"Roth","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0009-8981(99)00099-6","article-title":"Regulation of plasma fatty acid metabolism","volume":"286","author":"Saleh","year":"1999","journal-title":"Clinica Chimica Acta; International Journal of Clinical Chemistry"},{"key":"10.1016\/j.ejphar.2009.04.042_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.phrs.2007.05.009","article-title":"Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus","volume":"56","author":"Sch\u00e4fer","year":"2007","journal-title":"Pharmacological Research: the Official Journal of the Italian Pharmacological Society"},{"key":"10.1016\/j.ejphar.2009.04.042_bib45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/hep.510290203","article-title":"Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis","volume":"29","author":"Schneider","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2001-17556","article-title":"Matrix as a modulator of hepatic fibrogenesis","volume":"21","author":"Schuppan","year":"2001","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.ejphar.2009.04.042_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.lfs.2007.04.035","article-title":"Regulation of LPS stimulated ROS production in peritoneal macrophages from alloxan-induced diabetic rats: involvement of high glucose and PPAR\u03b3","volume":"81","author":"Souza","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.ejphar.2009.04.042_bib48","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1536\/ihj.48.637","article-title":"Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease inTGF-beta(1)","volume":"48","author":"Takahashi","year":"2007","journal-title":"International Heart Journal"},{"key":"10.1016\/j.ejphar.2009.04.042_bib49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/ajpregu.00564.2007","article-title":"Metabolic syndrome and endothelial fibrinolytic capacity in obese adults","volume":"294","author":"Van Guilder","year":"2008","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.ejphar.2009.04.042_bib50","doi-asserted-by":"crossref","first-page":"12490","DOI":"10.1073\/pnas.93.22.12490","article-title":"Cross-talk between the insulin and angiotensin signaling systems","volume":"93","author":"Velloso","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ejphar.2009.04.042_bib51","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.53738\/REVMED.2007.3.124.1992","article-title":"Stratification of global cardiovascular risk according to the ESH\/ESC guidelines","volume":"3","author":"Waeber","year":"2007","journal-title":"Revue m\u00e9dicale Suisse"},{"key":"10.1016\/j.ejphar.2009.04.042_bib52","first-page":"58","article-title":"Fat-storing cells and liver fibrosis","volume":"2","author":"Wang","year":"1996","journal-title":"China national Journal of New Gastroenterology = Zhongguo Xin Xiao Hua Bing Xue Za Zhi"},{"key":"10.1016\/j.ejphar.2009.04.042_bib53","first-page":"5016","article-title":"Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition?","volume":"61","author":"Yang","year":"2001","journal-title":"Cancer Research"},{"key":"10.1016\/j.ejphar.2009.04.042_bib54","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/hep.20420","article-title":"Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis","volume":"40","author":"Yokohama","year":"2004","journal-title":"Hepatology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909003896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909003896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T08:15:42Z","timestamp":1739088942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299909003896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":54,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0014299909003896"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2009.04.042","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}