{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:02:06Z","timestamp":1791406926755,"version":"4.3.3"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["LZUJC2007006"],"award-info":[{"award-number":["LZUJC2007006"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20525206"],"award-info":[{"award-number":["20525206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20772052"],"award-info":[{"award-number":["20772052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["90813012"],"award-info":[{"award-number":["90813012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20060730017"],"award-info":[{"award-number":["20060730017"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["200807301028"],"award-info":[{"award-number":["200807301028"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.ejphar.2009.08.037","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T06:24:47Z","timestamp":1252477487000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats"],"prefix":"10.1016","volume":"621","author":[{"given":"Quan","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2009.08.037_bib1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-3565(25)10692-7","article-title":"Mechanisms underlying the cardiovascular responses to peripheral administration of NPFF in the rat","volume":"274","author":"Allard","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.08.037_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1128\/MCB.26.2.709-717.2006","article-title":"The G-protein-coupled receptor GPR103 regulates bone formation","volume":"26","author":"Baribault","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ejphar.2009.08.037_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0167-0115(84)90062-4","article-title":"Increases in arterial blood pressure in the rat in response to a new vertebrate neuropeptide, LPLRFamide, and a related molluscan peptide, FMRFamide","volume":"8","author":"Barnard","year":"1984","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2009.08.037_bib4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/cne.21400","article-title":"Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat","volume":"503","author":"Bruzzone","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.regpep.2005.04.005","article-title":"Structure\u2013activity studies on different modifications of nociceptin\/orphanin FQ: identification of highly potent agonists and antagonists of its receptor","volume":"130","author":"Chang","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2009.08.037_bib6","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.peptides.2005.06.035","article-title":"Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates","volume":"27","author":"Chartrel","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib7","doi-asserted-by":"crossref","first-page":"15247","DOI":"10.1073\/pnas.2434676100","article-title":"Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity","volume":"100","author":"Chartrel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2009.08.037_bib8","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.peptides.2006.04.017","article-title":"Behavioral effects of 26RFamide and related peptides","volume":"27","author":"Do Rego","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0022-3565(25)12027-2","article-title":"Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226","volume":"275","author":"Doods","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.08.037_bib10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.peptides.2006.04.004","article-title":"26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas","volume":"28","author":"Egido","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib11","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.peptides.2006.04.002","article-title":"In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist","volume":"27","author":"Fang","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib12","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.peptides.2005.10.021","article-title":"In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors","volume":"27","author":"Fang","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib13","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.peptides.2005.06.031","article-title":"Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP","volume":"27","author":"Fukusumi","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib14","doi-asserted-by":"crossref","first-page":"46387","DOI":"10.1074\/jbc.M305270200","article-title":"A new peptidic ligand and its receptor regulating adrenal function in rats","volume":"278","author":"Fukusumi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2009.08.037_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(97)01128-X","article-title":"Effect of nociceptin on heart rate and blood pressure in anaesthetized rats","volume":"333","author":"Giuliani","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neuropharm.2006.07.034","article-title":"Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPgammaS binding","volume":"52","author":"Gouarderes","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2009.08.037_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1365-2826.2003.00869.x","article-title":"Central administration of neuropeptide FF causes activation of oxytocin paraventricular hypothalamic neurones that project to the brainstem","volume":"15","author":"Jhamandas","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib18","doi-asserted-by":"crossref","first-page":"27652","DOI":"10.1074\/jbc.M302945200","article-title":"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155","volume":"278","author":"Jiang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2009.08.037_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2006.08.055","article-title":"Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat","volume":"1119","author":"Kampe","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.08.037_bib20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejphar.2008.05.049","article-title":"Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4\u201311) in anesthetized rats","volume":"590","author":"Kong","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-8993(95)01382-2","article-title":"Cardiovascular effects induced by the stimulation of neuropeptide FF receptors in the dorsal vagal complex: an autoradiographic and pharmacological study in the rat","volume":"711","author":"Laguzzi","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2009.08.037_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-1119(01)00651-5","article-title":"Discovery and mapping of ten novel G protein-coupled receptor genes","volume":"275","author":"Lee","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2009.08.037_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(02)01889-7","article-title":"Pharmacology of neuropeptide Y receptor antagonists. Focus on cardiovascular functions","volume":"447","author":"Malmstrom","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib24","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1210\/en.2005-1580","article-title":"RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice","volume":"147","author":"Moriya","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2009.08.037_bib25","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/0024-3205(82)90728-7","article-title":"Blood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2","volume":"31","author":"Mues","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.08.037_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1113\/jphysiol.2006.106856","article-title":"Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis","volume":"573","author":"Navarro","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib27","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/sj.bjp.0703709","article-title":"Relevance of the C-terminal Arg-Phe sequence in gamma(2)-melanocyte-stimulating hormone (gamma(2)-MSH) for inducing cardiovascular effects in conscious rats","volume":"131","author":"Nijsen","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.08.037_bib28","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1210\/en.2007-1562","article-title":"Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic\u2013pituitary\u2013gonadal axis via gonadotropin-releasing hormone in rats","volume":"149","author":"Patel","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2009.08.037_bib29","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.877582","article-title":"Structure of a molluscan cardioexcitatory neuropeptide","volume":"197","author":"Price","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2009.08.037_bib30","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.peptides.2008.07.024","article-title":"Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in rats","volume":"29","author":"Primeaux","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2009.08.037_bib31","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1073\/pnas.0602371103","article-title":"A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice","volume":"103","author":"Takayasu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2009.08.037_bib32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0006-291X(05)81237-9","article-title":"FMRF-amide and l-Arg-l-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system","volume":"175","author":"Thiemermann","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2009.08.037_bib33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.peptides.2005.01.006","article-title":"Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity","volume":"26","author":"Thuau","year":"2005","journal-title":"Peptides"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909007183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909007183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:10:18Z","timestamp":1757974218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299909007183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":33,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0014299909007183"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2009.08.037","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2009.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}