{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:25:57Z","timestamp":1774437957990,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.ejphar.2009.11.015","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T13:53:14Z","timestamp":1258552394000},"page":"171-178","source":"Crossref","is-referenced-by-count":44,"title":["Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats"],"prefix":"10.1016","volume":"628","author":[{"given":"Wenhui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Fievez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Cheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Bureau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifang","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Advenier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Gustin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2009.11.015_bib1","first-page":"361","article-title":"Pathogenesis of COPD. Part I. The role of protease\u2013antiprotease imbalance in emphysema","volume":"12","author":"Abboud","year":"2008","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"10.1016\/j.ejphar.2009.11.015_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbrc.2007.07.093","article-title":"Acetylcholine induces neurite outgrowth and modulates matrix metalloproteinase 2 and 9","volume":"362","author":"Anelli","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2009.11.015_bib3","doi-asserted-by":"crossref","first-page":"L1319","DOI":"10.1152\/ajplung.00329.2003","article-title":"Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn","volume":"286","author":"Antonicelli","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2147\/COPD.S3945","article-title":"Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro","volume":"3","author":"Asano","year":"2008","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.ejphar.2009.11.015_bib5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tvjl.2007.10.004","article-title":"Characterisation of the acute and reversible airway inflammation induced by cadmium chloride inhalation in healthy dogs and evaluation of the effects of salbutamol and prednisolone","volume":"179","author":"Bolognin","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.ejphar.2009.11.015_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1183\/09031936.00004907","article-title":"Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison","volume":"30","author":"Bos","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2009.11.015_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1152\/jappl.1994.77.1.397","article-title":"Inhibition of neutrophil and eosinophil adhesion to venules of rat trachea by beta 2-adrenergic agonist formoterol","volume":"77","author":"Bowden","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1164\/rccm.200212-1396OC","article-title":"Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release","volume":"167","author":"Churg","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2009.11.015_bib9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2008.08.004","article-title":"Oxidants and the pathogenesis of lung diseases","volume":"122","author":"Ciencewicki","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1590\/S0100-879X2000000700004","article-title":"Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury","volume":"33","author":"Corbel","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ejphar.2009.11.015_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/pupt.1999.0178","article-title":"Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide","volume":"12","author":"Corbel","year":"1999","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2009.11.015_bib12","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.lfs.2008.02.008","article-title":"Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux","volume":"82","author":"Cui","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.11.015_bib13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/01.shk.0000194042.18699.b4","article-title":"Modulation of lipopolysaccharide-induced acute lung inflammation: role of insulin","volume":"25","author":"de Oliveira Martins","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2009.11.015_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0041-008X(92)90295-4","article-title":"Altered capillary filtration coefficient in parathion- and paraoxon-induced edema in isolated and perfused rabbit lungs","volume":"116","author":"Delaunois","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0022-3565(25)22333-3","article-title":"Modulation of the acetylcholine- and substance P-induced pulmonary edema by calcitonin gene-related peptide in the rabbit","volume":"270","author":"Delaunois","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2009.11.015_bib16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00000542-200110000-00025","article-title":"Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury","volume":"95","author":"Dhingra","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2009.11.015_bib17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1513\/pats.200505-047SR","article-title":"Combination therapy for chronic obstructive pulmonary disease: clinical aspects","volume":"2","author":"Donohue","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.ejphar.2009.11.015_bib18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.humpath.2005.11.023","article-title":"Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury","volume":"37","author":"Fligiel","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/01902149409031735","article-title":"Cadmium chloride and cadmium metallothionein-induced pulmonary injury and recruitment of polymorphonuclear leukocytes","volume":"20","author":"Gavett","year":"1994","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.ejphar.2009.11.015_bib20","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.162.6.3653","article-title":"Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury","volume":"162","author":"Gipson","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1465-9921-7-73","article-title":"Muscarinic receptor signaling in the pathophysiology of asthma and COPD","volume":"7","author":"Gosens","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2009.11.015_bib22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.pharmthera.2007.05.007","article-title":"The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?","volume":"115","author":"Gwilt","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2009.11.015_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/1568010043343598","article-title":"Anti-inflammatory activities of beta2-agonists","volume":"3","author":"Hanania","year":"2004","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.ejphar.2009.11.015_bib24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(04)16900-6","article-title":"Pathophysiology of airflow limitation in chronic obstructive pulmonary disease","volume":"364","author":"Hogg","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2009.11.015_bib25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1164\/ajrccm.156.3.9606019","article-title":"Effect of beta 2-agonists on histamine-induced airway microvascular leakage in ozone-exposed guinea pigs","volume":"156","author":"Inoue","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2009.11.015_bib26","doi-asserted-by":"crossref","first-page":"S282","DOI":"10.1067\/mai.2002.129430","article-title":"Effects of beta2-agonists on resident and infiltrating inflammatory cells","volume":"110","author":"Johnson","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/gast.2002.30348","article-title":"Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat","volume":"122","author":"Keck","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2009.11.015_bib28","doi-asserted-by":"crossref","first-page":"L580","DOI":"10.1152\/ajplung.00270.2005","article-title":"Inhibition of matrix metalloproteinase-9 prevents neutrophilic inflammation in ventilator-induced lung injury","volume":"291","author":"Kim","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tvjl.2005.10.007","article-title":"Non-invasive assessment of airway responsiveness in healthy and allergen-sensitised cats by use of barometric whole body plethysmography","volume":"173","author":"Kirschvink","year":"2007","journal-title":"Vet. J."},{"key":"10.1016\/j.ejphar.2009.11.015_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tox.2005.02.012","article-title":"Repeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and emphysema in rats","volume":"211","author":"Kirschvink","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2009.11.015_bib31","doi-asserted-by":"crossref","first-page":"H810","DOI":"10.1152\/ajpheart.00724.2007","article-title":"Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress","volume":"294","author":"LaCroix","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1465-9921-10-12","article-title":"The effect of tiotropium therapy on markers of elastin degradation in COPD","volume":"10","author":"Ma","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2009.11.015_bib33","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1378\/chest.128.4.1936","article-title":"Formoterol attenuates neutrophilic airway inflammation in asthma","volume":"128","author":"Maneechotesuwan","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2009.11.015_bib34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/thorax.2003.012054","article-title":"Urinary cadmium levels predict lower lung function in current and former smokers: data from the Third National Health and Nutrition Examination Survey","volume":"59","author":"Mannino","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2009.11.015_bib35","doi-asserted-by":"crossref","first-page":"L1122","DOI":"10.1152\/ajplung.00125.2003","article-title":"Salmeterol, a beta2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice","volume":"286","author":"Maris","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib36","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.taap.2006.11.034","article-title":"Bilateral vagotomy or atropine pre-treatment reduces experimental diesel-soot induced lung inflammation","volume":"219","author":"McQueen","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib37","doi-asserted-by":"crossref","first-page":"C168","DOI":"10.1152\/ajpcell.00606.2004","article-title":"Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes","volume":"289","author":"Menon","year":"2005","journal-title":"Am. J. Physiol Cell Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1183\/09031936.04.00035204","article-title":"Beta-adrenoceptor stimulation and neutrophil accumulation in mouse airways","volume":"24","author":"Miyamoto","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2009.11.015_bib39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2170\/jjphysiol.R2118","article-title":"Beta-adrenoceptor agonist clenbuterol down-regulates matrix metalloproteinase (MMP-9) and results in an impairment of collagen turnover in mice left ventricle","volume":"55","author":"Patiyal","year":"2005","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib40","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1398-9995.2005.00892.x","article-title":"Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients","volume":"60","author":"Profita","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2009.11.015_bib41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1513\/pats.200504-038SR","article-title":"Beta2-agonist and anticholinergic drugs in the treatment of lung disease","volume":"2","author":"Proskocil","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.ejphar.2009.11.015_bib42","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1164\/rccm.200208-794OC","article-title":"Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease","volume":"168","author":"Qiu","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2009.11.015_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jneuroim.2007.11.019","article-title":"Role of muscarinic receptors in the regulation of immune and inflammatory responses","volume":"194","author":"Razani-Boroujerdi","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1164\/ajrccm.156.2.96-12079","article-title":"Acetylcholine via muscarinic receptors inhibits histamine release from human isolated bronchi","volume":"156","author":"Reinheimer","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2009.11.015_bib45","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1164\/ajrccm.154.2.8756805","article-title":"Matrix metalloproteinases and TIMP in acute respiratory distress syndrome","volume":"154","author":"Ricou","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2009.11.015_bib46","first-page":"L970","article-title":"Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity","volume":"274","author":"Sato","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib47","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/01.RES.86.7.807","article-title":"beta-blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction","volume":"86","author":"Senzaki","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2009.11.015_bib48","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2174\/156801005774912824","article-title":"Inflammatory cells and chronic obstructive pulmonary disease","volume":"4","author":"Tetley","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.ejphar.2009.11.015_bib49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-2999(91)90197-X","article-title":"Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage","volume":"193","author":"Tokuyama","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib50","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0014-2999(95)00656-7","article-title":"Characterization of muscarinic receptor and beta-adrenoceptor interactions in guinea-pig oesophageal muscularis mucosae","volume":"294","author":"Watson","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib51","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.lfs.2007.01.027","article-title":"Dysfunctional inhibitory muscarinic receptors mediate enhanced histamine release in isolated human bronchi","volume":"80","author":"Wessler","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2009.11.015_bib52","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1476-5381.1993.tb13855.x","article-title":"Comparison of the anti-inflammatory properties of formoterol, salbutamol and salmeterol in guinea-pig skin and lung","volume":"110","author":"Whelan","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib53","doi-asserted-by":"crossref","first-page":"L953","DOI":"10.1152\/ajplung.00184.2003","article-title":"Evidence for a role of heat shock factor 1 in inhibition of NF-kappaB pathway during heat shock response-mediated lung protection","volume":"287","author":"Wirth","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2009.11.015_bib54","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.lfs.2007.01.052","article-title":"The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro","volume":"80","author":"Yeh","year":"2007","journal-title":"Life Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909010309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299909010309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:51:12Z","timestamp":1739436672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299909010309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":54,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0014299909010309"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2009.11.015","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}