{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:29:35Z","timestamp":1790562575946,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ejphar.2010.03.026","type":"journal-article","created":{"date-parts":[[2010,4,11]],"date-time":"2010-04-11T04:24:08Z","timestamp":1270959848000},"page":"88-95","source":"Crossref","is-referenced-by-count":35,"title":["The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: Comparison to sibutramine and rimonabant"],"prefix":"10.1016","volume":"636","author":[{"given":"Henrik H.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Tang-Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie D.","family":"Axel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Raben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D.","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.03.026_bib1","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/S0140-6736(08)61525-1","article-title":"Effect of tesofensine on body weight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Astrup","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2010.03.026_bib2","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/oby.2008.56","article-title":"Weight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease","volume":"16","author":"Astrup","year":"2008","journal-title":"Obesity (Silver Spring Md)"},{"key":"10.1016\/j.ejphar.2010.03.026_bib3","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/S0028-3908(00)00083-6","article-title":"Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid","volume":"39","author":"Balcioglu","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2010.03.026_bib4","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.npp.1301155","article-title":"Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice","volume":"32","author":"Billes","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2010.03.026_bib5","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/sj.npp.1301526","article-title":"Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis","volume":"33","author":"Billes","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2010.03.026_bib6","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1053\/j.gastro.2007.03.053","article-title":"Drug treatment of the overweight patient","volume":"132","author":"Bray","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.03.026_bib7","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/sj.bjp.0704030","article-title":"Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y","volume":"132","author":"Brown","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1385\/ENDO:29:2:375","article-title":"Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice","volume":"29","author":"Bush","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.ejphar.2010.03.026_bib9","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/sj.bjp.0702446","article-title":"Thermogenic effects of sibutramine and its metabolites","volume":"126","author":"Connoley","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pharmthera.2007.09.001","article-title":"The development of tolerance to drugs that suppress food intake","volume":"117","author":"Fernstrom","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2010.03.026_bib11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/sj.bjp.0706807","article-title":"Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats","volume":"148","author":"Fisas","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.neuron.2006.09.006","article-title":"Leptin regulation of the mesoaccumbens dopamine pathway","volume":"51","author":"Fulton","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2010.03.026_bib13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.21641","article-title":"Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa\/fa rats","volume":"46","author":"Gary-Bobo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2010.03.026_bib14","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1096\/fj.08-110759","article-title":"Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats","volume":"22","author":"Geiger","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2010.03.026_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(00)00216-8","article-title":"Enantioselective behavioral effects of sibutramine metabolites","volume":"397","author":"Glick","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib16","first-page":"397","article-title":"Beneficial health effects of modest weight loss","volume":"16","author":"Goldstein","year":"1992","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.ejphar.2010.03.026_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.pbb.2006.03.014","article-title":"Locomotion is the major determinant of sibutramine-induced increase in energy expenditure","volume":"83","author":"Golozoubova","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2010.03.026_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2010.03.026_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.bjp.0702067","article-title":"A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents","volume":"125","author":"Heal","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib20","series-title":"Development, Regulatory and Marketing Challenges for Novel Anti-obesity Therapies. Obesity and Metabolic Disorders","first-page":"73","author":"Heal","year":"2005"},{"key":"10.1016\/j.ejphar.2010.03.026_bib21","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.bjp.0701311","article-title":"Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat","volume":"121","author":"Jackson","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib22","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/sj.bjp.0701312","article-title":"Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat","volume":"121","author":"Jackson","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance","volume":"106","author":"Kahn","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2010.03.026_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/sj.bjp.0707539","article-title":"Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic\u2013pharmacodynamic modelling approach","volume":"153","author":"Lehr","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib25","doi-asserted-by":"crossref","first-page":"R2222","DOI":"10.1152\/ajpregu.2000.279.6.R2222","article-title":"Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats","volume":"279","author":"Levin","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2010.03.026_bib26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0899-9007(00)00449-4","article-title":"Hypothalamic dopamine and serotonin in the regulation of food intake","volume":"16","author":"Meguid","year":"2000","journal-title":"Nutrition (Burbank, Los Angeles County, Calif)"},{"key":"10.1016\/j.ejphar.2010.03.026_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/ENDO:29:1:49","article-title":"Central nervous system biogenic amine targets for control of appetite and energy expenditure","volume":"29","author":"Nelson","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.ejphar.2010.03.026_bib28","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.2337\/db08-0161","article-title":"Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats","volume":"57","author":"Nogueiras","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2010.03.026_bib29","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tins.2007.06.004","article-title":"Is dopamine a physiologically relevant mediator of feeding behavior?","volume":"30","author":"Palmiter","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2010.03.026_bib30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/oby.2009.245","article-title":"Characterization of beta-Cell Mass and Insulin Resistance in Diet-induced Obese and Diet-resistant Rats","volume":"18","author":"Paulsen","year":"2010","journal-title":"Obesity (Silver Spring, Md.)"},{"key":"10.1016\/j.ejphar.2010.03.026_bib31","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1001\/jama.295.7.761","article-title":"Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial","volume":"295","author":"Pi-Sunyer","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2010.03.026_bib32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pbb.2006.06.001","article-title":"The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake","volume":"84","author":"Thornton-Jones","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2010.03.026_bib33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1124\/jpet.107.133132","article-title":"The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity","volume":"324","author":"Tizzano","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.03.026_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nn1452","article-title":"How can drug addiction help us understand obesity?","volume":"8","author":"Volkow","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2010.03.026_bib35","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1056\/NEJMoa050156","article-title":"Randomized trial of lifestyle modification and pharmacotherapy for obesity","volume":"353","author":"Wadden","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2010.03.026_bib36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/sj.bjp.0702859","article-title":"Modulation of sibutramine-induced increases in extracellular noradrenaline concentration in rat frontal cortex and hypothalamus by alpha2-adrenoceptors","volume":"128","author":"Wortley","year":"1999","journal-title":"Br. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910002232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910002232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:22:20Z","timestamp":1559002940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910002232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":36,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0014299910002232"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.03.026","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}