{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:27:34Z","timestamp":1771331254775,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ejphar.2010.04.007","type":"journal-article","created":{"date-parts":[[2010,4,24]],"date-time":"2010-04-24T04:24:46Z","timestamp":1272083086000},"page":"162-170","source":"Crossref","is-referenced-by-count":23,"title":["Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration"],"prefix":"10.1016","volume":"637","author":[{"given":"Amr A.","family":"Fouad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Ibrahim","family":"Al-Sultan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed T.","family":"Yacoubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafaey","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.04.007_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1113\/jphysiol.1982.sp014065","article-title":"Gastric acid response to pylorus ligation in rats: is gastrin or histamine involved?","volume":"323","author":"Alumets","year":"1982","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1053\/gast.2000.16497","article-title":"Mechanism of NSAID-induced gastrointestinal injury defined using mutant mice","volume":"119","author":"Bech","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.04.007_bib3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.HYP.0000123072.34629.57","article-title":"Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR\u03b3-modulating activity","volume":"43","author":"Benson","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2010.04.007_bib4","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1074\/jbc.M210328200","article-title":"A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical","volume":"278","author":"Biswas","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.04.007_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.atherosclerosis.2007.10.037","article-title":"Anti-atherosclerotic properties of telmisartan in advanced atherosclerotic lesions in apolipoprotein E deficient mice","volume":"199","author":"Blessing","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2010.04.007_bib6","first-page":"643","article-title":"Prevalence of silent gastric ulcer, erosions or severe acute gastritis in patients with type 2 diabetes mellitus\u2014a cross sectional study","volume":"54","author":"Boehme","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ejphar.2010.04.007_bib7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1196\/annals.1296.044","article-title":"Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress","volume":"1018","author":"Bregonzio","year":"2004","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2010.04.007_bib8","first-page":"773","article-title":"Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor","volume":"55","author":"Brzozowska","year":"2004","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0165-6147(03)00233-5","article-title":"The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases","volume":"24","author":"Cai","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2010.04.007_bib10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/00313020902885037","article-title":"Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines","volume":"41","author":"Carl-McGrath","year":"2009","journal-title":"Pathology"},{"key":"10.1016\/j.ejphar.2010.04.007_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.510290101","article-title":"Death receptors in liver biology and pathobiology","volume":"29","author":"Faubion","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2010.04.007_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0024-3205(02)02301-9","article-title":"Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat","volume":"72","author":"Gao","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2010.04.007_bib13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1053\/gast.1997.v112.pm9041247","article-title":"Gastric mucosal damage in experimental diabetes in rats: role of endogenous glutathione","volume":"112","author":"Goldin","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.04.007_bib14","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00428-005-0002-7","article-title":"Tissue microarray of head and neck squamous carcinoma: validation of the methodology for the study of cutaneous fatty acid-binding protein, vascular endothelial growth factor, involucrin and Ki-67","volume":"447","author":"Gomaa","year":"2005","journal-title":"Virchows Arch."},{"key":"10.1016\/j.ejphar.2010.04.007_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-008-9772-y","article-title":"Effect of telmisartan on cardiovascular complications associated with streptozotocin diabetic rats","volume":"314","author":"Goyal","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2010.04.007_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0014-2999(91)90126-B","article-title":"Gastric hyperacidity and mucosal damage caused by hypothermia correlate with increase in GABA concentrations of the rat brain","volume":"194","author":"Hara","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejphar.2009.01.001","article-title":"Telmisartan, an angiotensin II type 1 receptor blocker, prevents the development of diabetes in male spontaneously diabetic Torii rats","volume":"605","author":"Hasegawa","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0885-3924(00)00175-5","article-title":"The gastroduodenal toxicity of nonsteroidal anti-inflammatory drugs. A review of the literature","volume":"20","author":"Hawkins","year":"2000","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.ejphar.2010.04.007_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-2036.1999.00496.x","article-title":"Effect of angiotensin II and telmisartan, an angiotensin1 receptor antagonist, on rat gastric mucosal blood flow","volume":"13","author":"Heinemann","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2010.04.007_bib20","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.3748\/wjg.v11.i37.5853","article-title":"Effect of lysozyme chloride on betel quid chewing aggravated gastric oxidative stress and hemorrhagic ulcer in diabetic rats","volume":"11","author":"Hung","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/biof.552210153","article-title":"Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress","volume":"21","author":"Iwai","year":"2004","journal-title":"Biofactors"},{"key":"10.1016\/j.ejphar.2010.04.007_bib22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1124\/jpet.107.120097","article-title":"Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage","volume":"322","author":"Jung","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.04.007_bib23","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1097\/HJH.0b013e328313e547","article-title":"Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation","volume":"26","author":"Kaschina","year":"2008","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2010.04.007_bib24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ajh.2008.27","article-title":"Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats","volume":"21","author":"Kobayashi","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2010.04.007_bib25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/00365520310002904","article-title":"Pioglitazone, a specific ligand of the peroxisome proliferator-activated receptor gamma reduces gastric mucosal injury induced by ischaemia\/reperfusion in rat","volume":"38","author":"Konturek","year":"2003","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1159\/000007702","article-title":"Increased susceptibility of diabetic rat gastric mucosa to food deprivation during cold stress","volume":"60","author":"Korolkiewicz","year":"1999","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2010.04.007_bib27","first-page":"2327","article-title":"Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia\u2013reperfusion","volume":"272","author":"Liu","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/153537020623100202","article-title":"Gastrointestinal inflammation: a central component of mucosal defense and repair","volume":"231","author":"Martin","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2010.04.007_bib29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2337\/diabetes.47.2.224","article-title":"Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide","volume":"47","author":"Masiello","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2010.04.007_bib30","first-page":"G601","article-title":"Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms","volume":"245","author":"Miller","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib31","first-page":"292","article-title":"Effect of plantain banana on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins, cell proliferation, antioxidants and free radicals","volume":"44","author":"Mohan Kumar","year":"2006","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2009.03.024","article-title":"Telmisartan, an angiotensin II type 1 receptor antagonist, attenuates T-type Ca2+ channel expression in neonatal rat cardiomyocytes","volume":"609","author":"Morishima","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib33","first-page":"E829","article-title":"New insights into the regulation of inducible nitric oxide synthesis","volume":"266","author":"Morris","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib34","first-page":"590","article-title":"Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats","volume":"64","author":"Morsy","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejphar.2010.04.007_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1440-1681.2009.05250.x","article-title":"Gastroprotective effects of the insulin sensitizers, rosiglitazone and metformin, in indomethacin-induced gastric ulcer in type 2 diabetic rats","volume":"37","author":"Morsy","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2005.01.036","article-title":"Oxidative DNA injury after experimental intracerebral hemorrhage","volume":"1039","author":"Nakamura","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2010.04.007_bib37","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1196\/annals.1410.006","article-title":"Peripherally administered angiotensin II AT1 receptor antagonists are anti-stress compounds in vivo","volume":"1148","author":"Pavel","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2010.04.007_bib38","first-page":"149","article-title":"Gastric infection by Helicobacter pylori and antral gastritis in hyperglycemic obese and in diabetic subjects","volume":"19","author":"Perdichizzi","year":"1996","journal-title":"New Microbiol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5414\/CPP40111","article-title":"Results of systematic screening for serious gastrointestinal bleeding associated with NSAIDs in Rostock hospitals","volume":"40","author":"Pietzsch","year":"2002","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2010.04.007_bib40","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/0006-2952(80)90286-5","article-title":"Biochemical gastroprotection from acute ulceration induced by aspirin and related drugs","volume":"29","author":"Rainsford","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib41","series-title":"Peptic Ulcer","first-page":"312","article-title":"The effect of cyproheptadine on gastric acidity","author":"Sanyal","year":"1971"},{"key":"10.1016\/j.ejphar.2010.04.007_bib42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.atherosclerosis.2005.08.009","article-title":"Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice","volume":"186","author":"Takaya","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2010.04.007_bib43","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/gast.1997.v112.pm9024295","article-title":"Alterations in duodenal bicarbonate secretion and mucosal susceptibility to acid in diabetic rats","volume":"112","author":"Takehara","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.04.007_bib44","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/sj.bjp.0701974","article-title":"Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats\u2014role of capsaicin-sensitive sensory neurons","volume":"124","author":"Tashima","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.007_bib45","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0024-3205(00)00754-2","article-title":"Aggravation of ischemia\/reperfusion-induced gastric lesions in streptozotocin-diabetic rats","volume":"67","author":"Tashima","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2010.04.007_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/HYPERTENSIONAHA.107.090472","article-title":"Angiotensin II-dependent superoxide: effects on hypertension and vascular dysfunction","volume":"52","author":"Welch","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2010.04.007_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110188.ch10","article-title":"Determination of serum glycoproteins","volume":"2","author":"Winzler","year":"1955","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.ejphar.2010.04.007_bib48","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.3748\/wjg.14.4784","article-title":"Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats","volume":"14","author":"Zhang","year":"2008","journal-title":"World J. Gastroenterol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910002967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910002967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:11:28Z","timestamp":1559052688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910002967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":48,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0014299910002967"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.04.007","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}