{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:26Z","timestamp":1786988126852,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ejphar.2010.04.017","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T04:37:45Z","timestamp":1272256665000},"page":"29-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression of NMDA receptor subunits in human peripheral blood lymphocytes in opioid addiction"],"prefix":"10.1016","volume":"638","author":[{"given":"Reza","family":"Roozafzoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Vousooghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Sedaghati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehr","family":"Yaghmaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Reza","family":"Zarrindast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.04.017_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorder","author":"American Psychiatric Institute","year":"1994"},{"key":"10.1016\/j.ejphar.2010.04.017_bib2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/jnr.20756","article-title":"Chronic morphine treatment alters expression of N-methyl-d-aspartate receptor subunits in the extended amygdala","volume":"83","author":"Bajo","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2010.04.017_bib3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00702-007-0661-4","article-title":"Dopamine and N-methyl-d-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal","volume":"114","author":"Biermann","year":"2007","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2010.04.017_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbrc.2004.09.019","article-title":"Rodent lymphocytes express functionally active glutamate receptors","volume":"324","author":"Boldyrev","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2010.04.017_bib5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-4159.2005.03456.x","article-title":"Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems","volume":"95","author":"Boldyrev","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2010.04.017_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0022-3956(87)90101-4","article-title":"3H-spiperone binding sites in lymphocytes as possible vulnerability marker in schizophrenia","volume":"21","author":"Bondy","year":"1987","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2010.04.017_bib7","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1523\/JNEUROSCI.16-09-03112.1996","article-title":"Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex","volume":"16","author":"Carlezon","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2010.04.017_bib8","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.neuroscience.2009.08.057","article-title":"Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection","volume":"164","author":"Chuhma","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2010.04.017_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/30748","article-title":"Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A","volume":"393","author":"Das","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2010.04.017_bib10","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1046\/j.1460-9568.1998.00150.x","article-title":"Rewarding effects elicited by the microinjection of either AMPA or NMDA glutamatergic antagonists into the ventral tegmental area revealed by an intracranial self-administration paradigm in mice","volume":"10","author":"David","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2010.04.017_bib11","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.4049\/jimmunol.170.8.4362","article-title":"Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration","volume":"170","author":"Ganor","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2010.04.017_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2007.06.039","article-title":"Glutamatergic substrates of drug addiction and alcoholism","volume":"75","author":"Gass","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.017_bib13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1073\/pnas.98.2.625","article-title":"A peripheral marker for schizophrenia: Increased levels of D3 dopamine receptor mRNA in blood lymphocytes","volume":"98","author":"Ilani","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2010.04.017_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00213-005-2200-z","article-title":"Ionotropic and metabotropic glutamate receptor structure and pharmacology","volume":"179","author":"Kew","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2010.04.017_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1749-6632.2000.tb06683.x","article-title":"Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine","volume":"909","author":"Kreek","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2010.04.017_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2350-2-3","article-title":"Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients","volume":"2","author":"Kwak","year":"2001","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.ejphar.2010.04.017_bib17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/sj.bjp.0704134","article-title":"Characterization of ionotropic glutamate receptors in human lymphocytes","volume":"133","author":"Lombardi","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.04.017_bib18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0197-4580(00)00258-X","article-title":"Influence of diet restriction on NMDA receptor subunits and learning during aging","volume":"22","author":"Magnusson","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2010.04.017_bib19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.neuint.2007.04.009","article-title":"The excitotoxic effect of NMDA on human lymphocyte immune function","volume":"51","author":"Mashkina","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2010.04.017_bib20","first-page":"651","article-title":"NMDA receptor subunit mRNA and protein expression in ethanol-withdrawal seizure-prone and -resistant mice","volume":"25","author":"Mason","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.ejphar.2010.04.017_bib21","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.bbrc.2005.10.164","article-title":"Human T lymphocytes express N-methyl-d-aspartate receptors functionally active in controlling T cell activation","volume":"338","author":"Miglio","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2010.04.017_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1460-9568.2004.03086.x","article-title":"Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit","volume":"19","author":"Miyamoto","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2010.04.017_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jchemneu.2004.11.002","article-title":"Distribution of the NMDA receptor NR3A subunit in the adult pig-tail macaque brain","volume":"29","author":"Mueller","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.ejphar.2010.04.017_bib24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1212\/WNL.46.3.791","article-title":"Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease","volume":"46","author":"Nagai","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2010.04.017_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2007.09.008","article-title":"Analysis of NR3A receptor subunits in human native NMDA receptors","volume":"1186","author":"Nilsson","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2010.04.017_bib26","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2010.04.017_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0306-4522(96)00089-9","article-title":"The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain","volume":"73","author":"Rigby","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2010.04.017_bib28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-2236(99)01447-2","article-title":"The dopamine hypothesis of reward: past and current status","volume":"22","author":"Spanagel","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2010.04.017_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0165-5728(00)00269-1","article-title":"Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells","volume":"109","author":"Storto","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejphar.2010.04.017_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/sj.mp.4001269","article-title":"Glutamatergic mechanisms in addiction","volume":"8","author":"Tzschentke","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.04.017_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-2999(98)00861-9","article-title":"Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment","volume":"365","author":"Zhu","year":"1999","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910003250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910003250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:11:25Z","timestamp":1757974285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910003250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":31,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0014299910003250"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.04.017","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of NMDA receptor subunits in human peripheral blood lymphocytes in opioid addiction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}