{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:15:48Z","timestamp":1786720548336,"version":"build-2736575974"},"reference-count":11,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.ejphar.2010.05.045","type":"journal-article","created":{"date-parts":[[2010,6,10]],"date-time":"2010-06-10T08:44:56Z","timestamp":1276159496000},"page":"226-228","source":"Crossref","is-referenced-by-count":26,"title":["Carbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucins"],"prefix":"10.1016","volume":"641","author":[{"given":"Yuji","family":"Ishibashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goh","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Inouye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.05.045_bib1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1165\/ajrcmb.20.3.3383","article-title":"Respiratory carcinoma cell lines. MUC genes and glycovonjugates","volume":"20","author":"Berger","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2010.05.045_bib11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrd2852","article-title":"From carbohydrate leads to glycomimetic drugs","volume":"8","author":"Ernst","year":"2009","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ejphar.2010.05.045_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/0264-6021:3580763","article-title":"Human mucin gene MUC5AC: organization of its 5\u2032-region and central repetitive region","volume":"358","author":"Escande","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2010.05.045_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1183\/09031936.93.05040477","article-title":"Role of the physiochemical properties of mucus in the protection of the respiratory epithelium","volume":"5","author":"Girod","year":"1992","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2010.05.045_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2003.12.038","article-title":"Effects of carbocisteine on altered activities of glycosidase and glycosyltransferase and expression of Muc5ac in SO2-exposed rats","volume":"487","author":"Ishibashi","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.05.045_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10719-005-0292-7","article-title":"Regulation of sialyl-Lewis x epitope expression by TNF-\u03b1 and EGF in an airway carcinoma cell line","volume":"22","author":"Ishibashi","year":"2005","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ejphar.2010.05.045_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejphar.2005.11.017","article-title":"Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor necrosis factor-\u03b1","volume":"530","author":"Ishibashi","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.05.045_bib7","first-page":"465","article-title":"Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases","volume":"117","author":"Lopez-Vidriero","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2010.05.045_bib8","doi-asserted-by":"crossref","first-page":"26103","DOI":"10.1074\/jbc.M202921200","article-title":"Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation","volume":"277","author":"Muller","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.05.045_bib9","first-page":"L835","article-title":"Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells","volume":"276","author":"Voynow","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2010.05.045_bib10","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(08)60869-7","article-title":"Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-control study","volume":"371","author":"Zheng","year":"2008","journal-title":"Lancet"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910004954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910004954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T14:33:11Z","timestamp":1685629991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910004954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":11,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0014299910004954"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.05.045","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}