{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:02:55Z","timestamp":1791270175850,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.ejphar.2010.06.049","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T04:36:28Z","timestamp":1278477388000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators"],"prefix":"10.1016","volume":"644","author":[{"given":"Yael","family":"Azriel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.06.049_bb0005","unstructured":"Azriel, Y., 2005. Neurotensin and its receptors in human isolated intestine in health and disease: focus on motility aspects. PhD thesis. University of New South Wales, Australia."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0010","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0022-3565(24)29635-X","article-title":"Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon","volume":"297","author":"Azriel","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0162-3109(98)00064-2","article-title":"Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C","volume":"41","author":"Barrocas","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0020","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.2042-7158.1992.tb07074.x","article-title":"The effects of various peptides on human isolated gut muscle","volume":"44","author":"Bennett","year":"1992","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0025","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1210\/jcem-51-6-1257","article-title":"Neurotensin infusion in man: pharmacokinetics and effect on gastrointestinal and pituitary hormones","volume":"51","author":"Blackburn","year":"1980","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0030","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0022-3565(25)09539-4","article-title":"Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon","volume":"273","author":"Botella","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0035","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/jpet.107.130385","article-title":"Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis","volume":"324","author":"Burcher","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0040","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/0196-9781(94)90123-6","article-title":"Binding and biologic activity of neurotensin in guinea pig ileum","volume":"15","author":"Carraway","year":"1994","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0045","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI4217","article-title":"Neurotensin is a proinflammatory neuropeptide in colonic inflammation","volume":"103","author":"Castagliuolo","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0050","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/sj.bjp.0702734","article-title":"In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips","volume":"127","author":"Croci","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0055","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0024-3205(98)00584-0","article-title":"Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle","volume":"64","author":"Ehlert","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1540\/jsmr.36.181","article-title":"Mediators and intracellular mechanisms of NANC relaxation of smooth muscle in the gastrointestinal tract","volume":"36","author":"Hata","year":"2000","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00511208","article-title":"Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals","volume":"53","author":"Helmstaedter","year":"1977","journal-title":"Histochemistry"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0070","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1476-5381.1983.tb10054.x","article-title":"Pharmacological characterization of the inhibitory effects of neurotensin on the rabbit ileum myenteric plexus preparation","volume":"80","author":"Huidobro-Toro","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0014-2999(88)90074-X","article-title":"Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach","volume":"158","author":"Katsoulis","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0080","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0016-5085(93)90943-7","article-title":"Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide","volume":"105","author":"Keef","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1749-6632.1982.tb31559.x","article-title":"Effects of neurotensin on intestinal smooth muscle: application to the study of structure\u2013activity relationships","volume":"400","author":"Kitabgi","year":"1982","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0014-2999(78)90140-1","article-title":"Effects of neurotensin on isolated intestinal smooth muscles","volume":"50","author":"Kitabgi","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0095","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0014-2999(79)90272-3","article-title":"Neurotensin contracts the guinea-pig longitudinal ileal smooth muscle by inducing acetylcholine release","volume":"56","author":"Kitabgi","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-2999(87)90678-9","article-title":"Extracellular calcium dependence of the neurotensin-induced relaxation of intestinal smooth muscles: studies with calcium channel blockers and BAY K-8644","volume":"135","author":"Kullak","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-2999(81)90494-5","article-title":"Histamine release induced by neurotensin from rat peritoneal mast cells","volume":"76","author":"Kurose","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.102.034702","article-title":"Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease","volume":"302","author":"Liu","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0898-6568(96)00180-5","article-title":"Signal transduction in gastrointestinal smooth muscle","volume":"9","author":"Makhlouf","year":"1997","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0928-4257(00)00154-6","article-title":"Modulation by GABA(B) and delta opioid receptors of neurally induced responses in isolated guinea-pig taenia coli and human colonic circular muscle","volume":"94","author":"Mako","year":"2000","journal-title":"J. Physiol. Paris"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0125","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1023\/A:1018858930745","article-title":"Motor responsiveness of proximal and distal human colonic muscle layers to carbachol and neurotensin","volume":"43","author":"Maselli","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1748-1716.1978.tb06275.x","article-title":"The effect of food ingestion on circulating neurotensin-like immunoreactivity (NTLI) in the human","volume":"104","author":"Mashford","year":"1978","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-2999(96)00943-0","article-title":"Mode and mechanism of neurotensin action in rat proximal colon","volume":"319","author":"Mul\u00e8","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-2999(94)00760-5","article-title":"Motility pattern of isolated rat proximal colon and excitatory action of neurotensin","volume":"275","author":"Mul\u00e8","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0145","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1139\/y97-045","article-title":"Pharmacological heterogeneity of neurotensin receptors: an in vitro study","volume":"75","author":"Nguyen-Le","year":"1997","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0150","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.peptides.2006.04.027","article-title":"Interactions between neurotensin and G proteins","volume":"27","author":"Pelaprat","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0155","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1124\/jpet.300.1.305","article-title":"The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin","volume":"300","author":"Pettibone","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/270183a0","article-title":"Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry","volume":"270","author":"Polak","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0165","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1053\/gast.2000.9310","article-title":"Neurotensin stimulates Cl(\u2212) secretion in human colonic mucosa In vitro: role of adenosine","volume":"119","author":"Riegler","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1748-1716.1979.tb06472.x","article-title":"The effect of ingestion of amino acids, glucose and fat on circulating neurotensin-like immunoreactivity (NTLI) in man","volume":"107","author":"Rosell","year":"1979","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1748-1716.1980.tb06609.x","article-title":"Plasma concentration of neurotensin-like immunoreactivity (NTLI) and lower esophageal sphincter (LES) pressure in man following infusion of (Gln4)-neurotensin","volume":"109","author":"Rosell","year":"1980","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0016-5085(86)90070-3","article-title":"Neurotensin increases colonic motility","volume":"90","author":"Thor","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0185","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1748-1716.1980.tb06673.x","article-title":"(Gln4)-neurotensin and gastrointestinal motility in man","volume":"110","author":"Thor","year":"1980","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0190","first-page":"1662","article-title":"The effects of neurotensin in the colon of patients with slow transit constipation","volume":"54","author":"Tomita","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ejphar.2010.06.049_bb0195","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0165-6147(99)01357-7","article-title":"Neurotensin and neurotensin receptors","volume":"20","author":"Vincent","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/sj.bjp.0704914","article-title":"A possible role of neurotensin in NANC relaxation of longitudinal muscle of the jejunum and ileum of Wistar rats","volume":"137","author":"Yamaji","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.06.049_bb0205","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.peptides.2005.12.016","article-title":"Effects of neurotensin on gastrointestinal motility and secretion, and role in intestinal inflammation","volume":"27","author":"Zhao","year":"2006","journal-title":"Peptides"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910006576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910006576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:11:44Z","timestamp":1757974304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910006576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":41,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0014299910006576"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.06.049","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.06.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}