{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:42:17Z","timestamp":1787870537876,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["R33-2008-000-10018-0"],"award-info":[{"award-number":["R33-2008-000-10018-0"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.ejphar.2010.08.046","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T04:43:11Z","timestamp":1283920991000},"page":"162-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-\u03baB activation"],"prefix":"10.1016","volume":"648","author":[{"given":"In-Ah","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Jin","family":"Hyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.08.046_bb0005","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/75068","article-title":"Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo","volume":"6","author":"Atreya","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0010","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1248\/bpb.21.990","article-title":"Anti-Helicobacter pylori activity of herbal medicines","volume":"21","author":"Bae","year":"1998","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bpg.2003.12.002","article-title":"Epidemiology of IBD during the twentieth century: an integrated view","volume":"18","author":"Binder","year":"2004","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0025","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1128\/IAI.68.12.7010-7017.2000","article-title":"Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease","volume":"68","author":"Cario","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF02818693","article-title":"Antimicrobial activity of berberine-a constituent of Mahonia aquifolium","volume":"47","author":"Cern\u00e1kov\u00e1","year":"2002","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0035","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","article-title":"Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction","volume":"274","author":"Chow","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0040","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1574-6941.2008.00520.x","article-title":"Distribution of \u03b2-glucosidase and \u03b2-glucuronidase activity and of \u03b2-glucuronidase gene gus in human colonic bacteria","volume":"66","author":"Dabek","year":"2008","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0045","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1021\/bi7018546","article-title":"Berberine targets assembly of Escherichia coli cell division protein FtsZ","volume":"47","author":"Domadia","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0050","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1053\/j.gastro.2006.06.017","article-title":"Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: role in proliferation and apoptosis in the intestine","volume":"131","author":"Fukata","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0944-7113(11)80024-3","article-title":"Analytical and pharmacological studies on Mahonia aquifolium","volume":"1","author":"Galle","year":"1994","journal-title":"Int. J. Phytomed."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0065","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/01.mib.0000235101.09231.9e","article-title":"Improvement of an experimental colitis in rats by lactic acid bacteria producing superoxide dismutase","volume":"12","author":"Han","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0070","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1472-765X.1992.tb00765.x","article-title":"Direct automated sequencing of 16S rDNA amplified by polymerase chain reaction from bacterial cultures without DNA purification","volume":"15","author":"Hiraishi","year":"1992","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0075","doi-asserted-by":"crossref","first-page":"14981","DOI":"10.1074\/jbc.M500966200","article-title":"Inhibition of RICK\/nuclear factor-kB and p38 signalling attenuates the inflammatory response in a murine model of Crohn disease","volume":"280","author":"Hollenbach","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0891-5520(05)70078-7","article-title":"Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors","volume":"13","author":"Ingalls","year":"1999","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI117676","article-title":"A distinct array of proinflammatory cytokine is expressed in human colon epithelia cells in response to bacterial invasion","volume":"95","author":"Jung","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0205","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1248\/bpb.27.1599","article-title":"Pharmacological properties of traditional medicine (XXlX): effect of Hange-shashin-to and the combinations of its herbal constituents on rat experimental colitis","volume":"27","author":"Kawashima","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0095","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1248\/bpb.18.1184","article-title":"Purification and characterization of \u03b2-glucuronidase from Escherichia coli HGU-3, a human intestinal bacterium","volume":"18","author":"Kim","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0100","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/path.1409","article-title":"Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants","volume":"201","author":"Kruidenier","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.phrs.2007.06.003","article-title":"Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells","volume":"56","author":"Lee","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00384-008-0618-6","article-title":"Lactobacillus suntoryeus inhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis","volume":"24","author":"Lee","year":"2009","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0120","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0160-5402(85)90029-4","article-title":"Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium","volume":"14","author":"Mullane","year":"1985","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0125","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00535-007-2096-y","article-title":"Molecular fingerprints of neutrophil-dependent-oxidative stress in inflammatory bowel disease","volume":"42","author":"Naito","year":"2007","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0130","first-page":"351","article-title":"Assay of lipid peroxidases in animal tissue by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1978","journal-title":"Anal. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0135","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidases","volume":"701","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0140","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1158\/0008-5472.CAN-08-0511","article-title":"Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis","volume":"68","author":"Pandey","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0145","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1073\/pnas.0801394105","article-title":"PAI-1 inhibits neutrophil efferocytosis","volume":"105","author":"Park","year":"2008","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0150","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1182\/blood-2008-12-193524","article-title":"Participation of the urokinase receptor in neutrophil efferocytosis","volume":"114","author":"Park","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0155","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0165","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.189.4.615","article-title":"Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)","volume":"1189","author":"Qureshi","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0170","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/0016-5085(91)70002-F","article-title":"Interleukin 1 beta is expressed predominantly by enterocytes in experimental colitis","volume":"100","author":"Radema","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0175","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1026634229934","article-title":"Changes in bacterial enzymes and PCR profiles of fecal bacteria from a patient with ulcerative colitis before and after antimicrobial treatments","volume":"44","author":"Rafii","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0180","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.prp.2008.04.011","article-title":"Oxidative stress in ulcerative colitis-associated carcinogenesis","volume":"204","author":"Roessner","year":"2008","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0185","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0140-6736(02)07284-7","article-title":"Crohn's disease","volume":"359","author":"Shanahan","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF02873586","article-title":"Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp","volume":"46","author":"Vollekova","year":"2001","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.ejphar.2010.08.046_bb0195","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/jmf.2005.8.454","article-title":"Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus","volume":"8","author":"Yu","year":"2005","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ejphar.2010.08.046_bb0200","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0022-3565(24)39141-4","article-title":"The effect of berberine chloride on experimental colitis in rats in vivo and in vitro","volume":"294","author":"Zhou","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910008502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910008502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:12:11Z","timestamp":1757974331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910008502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":38,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0014299910008502"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.08.046","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-\u03baB activation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.08.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}