{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:30:06Z","timestamp":1791282606978,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.ejphar.2010.09.035","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T08:24:56Z","timestamp":1285230296000},"page":"224-228","source":"Crossref","is-referenced-by-count":54,"title":["Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats"],"prefix":"10.1016","volume":"649","author":[{"given":"Kwok Ho Christopher","family":"Choy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van den Buuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.09.035_bb0005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/1098-2396(20001215)38:4<369::AID-SYN1>3.0.CO;2-Q","article-title":"Synaptic plasticity is impaired in rats with a low glutathione content","volume":"38","author":"Almaguer-Melian","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0010","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0003-2697(90)90208-Q","article-title":"Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples","volume":"190","author":"Baker","year":"1990","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0015","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/jnr.490290413","article-title":"Age-related acute depletion of cerebral glutathione by peroxidative stress","volume":"29","author":"Benzi","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0020","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S1461145708009498","article-title":"Neuroprogression: pathways to progressive brain changes in bipolar disorder","volume":"12","author":"Berk","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.biopsych.2008.03.004","article-title":"N-acetyl cysteine as a glutathione precursor for schizophrenia\u2014a double-blind, randomized, placebo-controlled trial","volume":"64","author":"Berk","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0030","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2008.04.022","article-title":"N-acetyl cysteine for depressive symptoms in bipolar disorder\u2014a double-blind randomized placebo-controlled trial","volume":"64","author":"Berk","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0035","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.tips.2008.05.001","article-title":"Glutathione: a novel treatment target in psychiatry","volume":"29","author":"Berk","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0040","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0006-3223(87)90069-2","article-title":"Glutathione peroxidase and CT scan abnormalities in schizophrenia","volume":"22","author":"Buckman","year":"1987","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0045","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.nbd.2007.03.001","article-title":"Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: relevance to schizophrenia","volume":"26","author":"Cabungcal","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0050","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/hipo.20425","article-title":"Combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory","volume":"18","author":"Choy","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0006-8993(97)00236-9","article-title":"The effects of type I and type II corticosteroid receptor agonists on exploratory behavior and spatial memory in the Y-maze","volume":"759","author":"Conrad","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0060","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jnr.20899","article-title":"Chronic systemic d-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid","volume":"84","author":"Cui","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0166-4328(02)00225-5","article-title":"Effects of medial prefrontal cortex cytotoxic lesions in mice","volume":"139","author":"Deacon","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbr.2008.11.017","article-title":"Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice","volume":"198","author":"Dean","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-8993(92)91352-F","article-title":"A two-trial memory task with automated recording: study in young and aged rats","volume":"588","author":"Dellu","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1006\/nlme.1997.3746","article-title":"Extension of a new two-trial memory task in the rat: influence of environmental context on recognition processes","volume":"67","author":"Dellu","year":"1997","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/nlme.1999.3919","article-title":"Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice","volume":"73","author":"Dellu","year":"2000","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0090","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1046\/j.1460-9568.2000.00229.x","article-title":"Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo","volume":"12","author":"Do","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0095","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.conb.2009.05.001","article-title":"Redox dysregulation, neurodevelopment, and schizophrenia","volume":"19","author":"Do","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2006.06.042","article-title":"Protective effect of N-acetyl-l-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice","volume":"1109","author":"Fu","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00176821","article-title":"Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 (acivicin) on glutathione and cysteine levels in rat brain and plasma","volume":"3","author":"Hill","year":"1985","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3940(93)90461-S","article-title":"Glutathione modulates the N-methyl-d-aspartate receptor-activated calcium influx into cultured rat cerebellar granule cells","volume":"156","author":"Janaky","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0163-1047(93)90664-4","article-title":"On the role of the hippocampus in learning and memory in the rat","volume":"60","author":"Jarrard","year":"1993","journal-title":"Behav. Neural Biol."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0120","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00221-005-0241-5","article-title":"Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine","volume":"170","author":"Kamboj","year":"2006","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(01)00334-6","article-title":"Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics","volume":"58","author":"Khan","year":"2002","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0920-9964(95)00049-6","article-title":"Free radical pathology and antioxidant defense in schizophrenia: a review","volume":"19","author":"Mahadik","year":"1996","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0024-3205(89)90266-X","article-title":"Methods for depleting brain glutathione","volume":"44","author":"Masukawa","year":"1989","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0140","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1017\/S1461145707008401","article-title":"Oxidative stress in psychiatric disorders: evidence base and therapeutic implications","volume":"11","author":"Ng","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0145","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0197-0186(00)00031-0","article-title":"Modulation of glutamate receptor functions by glutathione","volume":"37","author":"Oja","year":"2000","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neulet.2010.05.088","article-title":"Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics","volume":"479","author":"Padurariu","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1440-1819.2009.02015.x","article-title":"Oxidative mechanisms in schizophrenia and their relationship with illness subtype and symptom profile","volume":"63","author":"Pazvantoglu","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0160","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.pnpbp.2009.06.018","article-title":"Decreased glutathione levels and antioxidant enzyme activities in untreated and treated schizophrenic patients","volume":"33","author":"Raffa","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0165","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0920-9964(02)00407-3","article-title":"Reduced plasma antioxidants in first-episode patients with schizophrenia","volume":"62","author":"Reddy","year":"2003","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0170","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1086\/507566","article-title":"Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene","volume":"79","author":"Tosic","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0175","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nbd.2008.11.018","article-title":"Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation","volume":"33","author":"Wood","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2010.09.035_bb0180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1155\/2006\/248387","article-title":"Altered glutathione redox state in schizophrenia","volume":"22","author":"Yao","year":"2006","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ejphar.2010.09.035_bb0185","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.schres.2005.10.011","article-title":"Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics","volume":"81","author":"Zhang","year":"2006","journal-title":"Schizophr. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910009209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910009209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T22:55:16Z","timestamp":1544223316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910009209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":37,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0014299910009209"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.09.035","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}