{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:42:57Z","timestamp":1773661377434,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.ejphar.2010.09.080","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T05:45:19Z","timestamp":1287380719000},"page":"86-93","source":"Crossref","is-referenced-by-count":24,"title":["Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice"],"prefix":"10.1016","volume":"650","author":[{"given":"Kristian K.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil S.","family":"Geoghagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G.","family":"Holt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Malkowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Quan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Gerard","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiwu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather H.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-juan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.09.080_bb0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-4347(87)80438-3","article-title":"Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection","volume":"422","author":"Araki","year":"1987","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1570-9639(03)00044-X","article-title":"Reaction mechanism and regulation of cystathionine beta-synthase","volume":"1647","author":"Banerjee","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0015","doi-asserted-by":"crossref","first-page":"52082","DOI":"10.1074\/jbc.C400481200","article-title":"Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine","volume":"279","author":"Chen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0020","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00029330-200703010-00008","article-title":"Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children","volume":"120","author":"Chen","year":"2007","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0006-291X(75)80297-X","article-title":"Activation of cystathionine synthase by adenosylmethionine and adenosylethionine","volume":"66","author":"Finkelstein","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0030","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1021\/ac60030a028","article-title":"Spectrophotometric Determination of Hydrogen Sulfide","volume":"21","author":"Fogo","year":"1949","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2007.11.006","article-title":"Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli","volume":"470","author":"Frank","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1089\/adt.2009.0200","article-title":"Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications","volume":"7","author":"Holt","year":"2009","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0045","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0050","doi-asserted-by":"crossref","first-page":"10625","DOI":"10.1021\/bi010711p","article-title":"Regulation of human cystathionine beta-synthase by S-adenosyl-l-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region","volume":"40","author":"Janosik","year":"2001","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0055","first-page":"951","article-title":"Changes of the new gaseous transmitter H2S in patients with coronary heart disease","volume":"25","author":"Jiang","year":"2005","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0060","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0065","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/abbi.1998.0723","article-title":"Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences","volume":"355","author":"Kery","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen sulfide as a neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0075","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tips.2007.11.003","article-title":"Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?","volume":"29","author":"Li","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0080","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.coph.2005.10.007","article-title":"Hydrogen sulphide\u2014a novel mediator of inflammation?","volume":"6","author":"Li","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0085","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0090","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJMe068060","article-title":"Homocysteine trials\u2014clear outcomes for complex reasons","volume":"354","author":"Loscalzo","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0095","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2003.10.007","article-title":"Hydrogen sulfide: from the smell of the past to the mediator of the future?","volume":"24","author":"Moore","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yjmcc.2005.10.003","article-title":"Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes","volume":"40","author":"Pan","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0105","first-page":"146","article-title":"Endogenous hydrogen sulfide and the cardiovascular system\u2014what's the smell all about?","volume":"29","author":"Pearson","year":"2006","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0110","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/ATVBAHA.108.164830","article-title":"The homocysteine paradox","volume":"28","author":"Rodionov","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ng0598-91","article-title":"Correction of disease-causing CBS mutations in yeast","volume":"19","author":"Shan","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0120","doi-asserted-by":"crossref","first-page":"H2093","DOI":"10.1152\/ajpheart.00088.2007","article-title":"Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats","volume":"293","author":"Shi","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0125","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2060267","article-title":"Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat","volume":"206","author":"Stipanuk","year":"1982","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0130","first-page":"1145","article-title":"Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complications","volume":"35","author":"Sun","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0135","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0140","doi-asserted-by":"crossref","first-page":"25179","DOI":"10.1074\/jbc.273.39.25179","article-title":"Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity","volume":"273","author":"Taoka","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0145","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.tips.2007.09.003","article-title":"Hydrogen sulfide-releasing anti-inflammatory drugs","volume":"28","author":"Wallace","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0150","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.RES.0000129182.46440.4a","article-title":"Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice","volume":"94","author":"Wang","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0155","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/ATVBAHA.108.179333","article-title":"Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0160","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1073\/pnas.92.5.1585","article-title":"Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia","volume":"92","author":"Watanabe","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2003.11.081","article-title":"The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats","volume":"313","author":"Yan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0170","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2010.09.080_bb0175","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2010.09.080_bb0180","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/japplphysiol.00096.2006","article-title":"Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats","volume":"102","author":"Zhu","year":"2007","journal-title":"J. Appl. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910010034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910010034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T15:29:04Z","timestamp":1559748544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910010034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0014299910010034"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.09.080","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}