{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:07:37Z","timestamp":1762297657781},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.ejphar.2010.10.080","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T10:38:16Z","timestamp":1291113496000},"page":"181-186","source":"Crossref","is-referenced-by-count":17,"title":["N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats"],"prefix":"10.1016","volume":"654","author":[{"given":"Priya","family":"Sathish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayalakshmi","family":"Paramasivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivekanandan","family":"Palani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthikeyan","family":"Sivanesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.10.080_bb0005","first-page":"8171","article-title":"Inhibition of angiogenesis driven Kaposi's, sarcoma tumor growth in nude mice by oral N-acetylcysteine","volume":"61","author":"Albini","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0010","unstructured":"ATSDR (Agency for Toxic Substances and Disease Registry), 1989. US Public Health, Service. In Collaboration with US Environmental Protection Agency (EPA). Toxicological Profile for N-nitrosodimethylamine. 1\u2013119."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0015","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ptr.1933","article-title":"The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant, properties","volume":"20","author":"Bhattacharjee","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0025","first-page":"257","article-title":"Sodium potassium activated adenosine triphosphatase and cation, transport","volume":"vol. 1","author":"Bonting","year":"1970"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0030","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1006\/abbi.1993.1074","article-title":"The pecking order of free radicals and antioxidants: lipid, peroxidation, \u03b1-tocopherol, and ascorbate","volume":"300","author":"Buettner","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0035","series-title":"Free Radical Damage and its Control","first-page":"25","article-title":"Some chemical and biochemical constrains of oxidative stress in, living cells","author":"Chaudiere","year":"1994"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/phrs.2000.0772","article-title":"Effect of aminoguanidine and desferrioxamine on some biochemical changes associated with streptozotocin induced hyperglycemia in rats","volume":"43","author":"El-Khatib","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0050","first-page":"58","article-title":"The effect of N-acetylcysteine on brain tissue of rats fed with high cholesterol diet","volume":"33","author":"Eskiocak","year":"2008","journal-title":"Turk. J. Biochem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0055","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.fct.2007.09.095","article-title":"Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2 mediated induction of heme oxygenase-1","volume":"46","author":"Farombi","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.lfs.2008.11.012","article-title":"Kolaviron inhibits dimethylnitrosamine induced liver injury by suppressing COX-2 and iNOS expression via NF-\u03baB and AP-1","volume":"84","author":"Farombi","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0065","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1590\/S0004-28032008000200013","article-title":"Role of N-acetylcysteine on fibrosis and oxidative stress in cirrhotic rats","volume":"45","author":"Filho","year":"2008","journal-title":"Arq. Gastroenteral."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0070","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)84756-1","article-title":"The colorimetric determination of phosphorous","volume":"66","author":"Fiske","year":"1925","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0075","first-page":"G451","article-title":"Sodium coupled nonelectric transport across epithelia: emerging concepts and directions","volume":"241","author":"Freel","year":"1981","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0080","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1016\/S0168-8278(10)60513-2","article-title":"N-acetylcysteine reverses cirrhosis induced by CCl4 in the rat","volume":"52","author":"Galicia","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0009-8981(03)00285-7","article-title":"Ascorbic acid concentrations in dimethylnitrosamine induced hepatic fibrosis in rats","volume":"335","author":"George","year":"2003","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(00)00352-8","article-title":"Dimethylnitrosamine induced liver injury in rats: the early deposition of collagen","volume":"156","author":"George","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0095","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00606554","article-title":"A controlled trial of intermittent oral acetylcysteine in the long term treatment of chronic bronchitis","volume":"9","author":"Grassi","year":"1976","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0100","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jlcr.2580340213","article-title":"Synthesis of 8-[18O] hydroxyl-2\u2032-deoxyguanosine","volume":"34","author":"Hermanns","year":"1994","journal-title":"J. Labelled Compd. Rad."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0110","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1523-1755.2003.00783.x","article-title":"N-acetylcysteine ameliorates renal microcirculation: studies in rats","volume":"63","author":"Heyman","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0005-2736(83)90480-7","article-title":"Purification and characterization of two forms of a low affinity Ca2+ ATPase from erythrocyte membranes","volume":"728","author":"Hjerten","year":"1983","journal-title":"Biochem. Biophys. Acta."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1440-1746.2006.04361.x","article-title":"Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis","volume":"22","author":"Hsu","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0125","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1515\/CCLM.2005.140","article-title":"Counteracting adriamycin induced oxidative stress by administration of N-acetylcysteine and vitamin-E","volume":"43","author":"Kalaiselvi","year":"2005","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1081\/DMR-120000652","article-title":"Induction of xenobiotic enzymes by the MAPkinase pathway and the antioxidant or electrophile response element (ARE\/EpRE)","volume":"33","author":"Kong","year":"2001","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0135","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1172\/JCI110853","article-title":"Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo","volume":"71","author":"Lauterburg","year":"1983","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0140","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.4049\/jimmunol.173.5.3467","article-title":"Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals","volume":"173","author":"Li","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0155","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0021-9258(19)83745-6","article-title":"Hepatic glutathione reductase. I. Purification and general kinetic properties","volume":"237","author":"Mize","year":"1962","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0160","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jtemb.2006.02.002","article-title":"Co-administration of zinc and N-acetylcysteine prevents arsenic induced tissue oxidative stress in male rats","volume":"20","author":"Modi","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0165","series-title":"Harpers Illustrated Biochemistry","author":"Murray","year":"2003"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0170","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.phymed.2006.02.005","article-title":"Protective effect of silymarin on oxidative stress in rat brain","volume":"14","author":"Nencini","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0175","first-page":"1725","article-title":"Physicochemical alterations in the conformation of rat liver chromatin induced by carcinogens in vivo","volume":"36","author":"Nicolini","year":"1976","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0180","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.burns.2004.05.006","article-title":"N-acetylcysteine on oxidative stress in intestine and bacterial translocation after thermal injury","volume":"30","author":"Ocal","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0185","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0190","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0005-2736(82)90050-5","article-title":"A comparative study of plasma membrane Mg2+ATPase activities in normal, regenerating and malignant cells","volume":"684","author":"Ohnishi","year":"1982","journal-title":"Biochem. Biophys. Acta."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0195","first-page":"1","article-title":"Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids","volume":"62","author":"Omaye","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0200","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3748\/wjg.v9.i1.125","article-title":"N-acetylcysteine attenuates alcohol induced oxidative stress in the rat","volume":"9","author":"Ozaras","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0205","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0041-008X(89)90327-X","article-title":"Inhibition by ethanol of rat liver plasma membrane Na+\/K+ ATPase: protective effect of s-adenosyl-l-methionine, l-methionine, and N-acetylcysteine","volume":"97","author":"Pascale","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0210","first-page":"451","article-title":"A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine","volume":"134","author":"Raza","year":"2003","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetate and glutamic pyruvic transaminases","volume":"58","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0220","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.freeradbiomed.2005.04.011","article-title":"Effects of N-acetylcysteine on ethanol induced hepatotoxicity in rats fed via total enteral nutrition","volume":"39","author":"Ronis","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0225","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0230","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0235","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jpba.2010.03.015","article-title":"Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats","volume":"53","author":"Sun","year":"2010","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0240","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1046\/j.1440-1681.2001.03481.x","article-title":"Pirfenidone inhibits dimethylnitrosamine induced hepatic fibrosis in rats","volume":"28","author":"Tada","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0245","first-page":"222","article-title":"Hormones, vitamins, drugs and poisons","volume":"vol-II","author":"Varley","year":"1976"},{"key":"10.1016\/j.ejphar.2010.10.080_bb0250","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/taap.2001.9234","article-title":"Increased oxidative stress in dimethylnitrosamine induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-\u03b1","volume":"175","author":"Vendemiale","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0255","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jep.2009.10.001","article-title":"Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats","volume":"127","author":"Wang","year":"2010","journal-title":"J. Ethanopharmacol."},{"key":"10.1016\/j.ejphar.2010.10.080_bb0260","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1382-6689(03)00045-0","article-title":"Protective effect of N-acetylcysteine against carbon tetrachloride and trichloroethylene induced poisoning in rats","volume":"14","author":"Wong","year":"2003","journal-title":"Environ. Toxicol. Pharmcol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910011313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910011313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T10:44:21Z","timestamp":1636886661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910011313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0014299910011313"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.10.080","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}