{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:51:43Z","timestamp":1773294703854,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK59630"],"award-info":[{"award-number":["DK59630"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH073704"],"award-info":[{"award-number":["MH073704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ejphar.2010.11.010","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T05:38:16Z","timestamp":1291095496000},"page":"152-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats"],"prefix":"10.1016","volume":"652","author":[{"given":"Robert K.","family":"McNamara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Jandacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Tso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.11.010_bb0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.schres.2006.11.016","article-title":"Celecoxib as adjunctive therapy in schizophrenia: a double-blind, randomized and placebo-controlled trial","volume":"90","author":"Akhondzadeh","year":"2007","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pnpbp.2007.06.031","article-title":"The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma","volume":"32","author":"Bian","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.11.010_bb0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.plefa.2008.09.016","article-title":"The relationship between the fatty acid composition of immune cells and their function","volume":"79","author":"Calder","year":"2008","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.ejphar.2010.11.010_bb0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1586\/ern.09.144","article-title":"The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder","volume":"10","author":"Drexhage","year":"2010","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0025","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbi.2006.02.002","article-title":"Cytokines in schizophrenia and the effects of antipsychotic drugs","volume":"20","author":"Drzyzga","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nchembio.367","article-title":"Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids","volume":"6","author":"Groeger","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0035","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1194\/jlr.M700315-JLR200","article-title":"Dietary n-3 PUFA deprivation for 15weeks upregulates elongase and desaturase expression in rat liver but not brain","volume":"48","author":"Igarashi","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0040","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.schres.2007.01.019","article-title":"Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro","volume":"92","author":"Kato","year":"2007","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0045","first-page":"589","article-title":"Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6","volume":"400","author":"Khalfoun","year":"1997","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0050","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1038\/npp.2010.98","article-title":"Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for omega-3 fatty acids","volume":"35","author":"Lu","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2010.11.010_bb0055","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2217\/clp.09.62","article-title":"Modulation of polyunsaturated fatty acid biosynthesis by antipsychotic medications: implications for the pathophysiology and treatment of schizophrenia","volume":"4","author":"McNamara","year":"2009","journal-title":"Clin. Lipidol."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0060","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jpsychires.2007.05.009","article-title":"Omega-3 fatty acid deficiency augments the development of behavioral sensitization in adult mice: prevention by chronic lithium treatment","volume":"42","author":"McNamara","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0065","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2008.09.027","article-title":"Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis","volume":"107","author":"McNamara","year":"2009","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.plefa.2010.08.004","article-title":"Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover","volume":"83","author":"McNamara","year":"2010","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.ejphar.2010.11.010_bb0075","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1111\/j.1460-9568.2008.06470.x","article-title":"Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice","volume":"28","author":"Mingam","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0080","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1084\/jem.184.3.883","article-title":"Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo","volume":"184","author":"Portanova","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0085","first-page":"115","article-title":"Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins","volume":"8","author":"Serhan","year":"2005","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.ejphar.2010.11.010_bb0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pnpbp.2008.12.006","article-title":"Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice","volume":"33","author":"Sugino","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2010.11.010_bb0095","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1152\/ajpcell.00508.2009","article-title":"Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP\/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation","volume":"298","author":"Wang","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2010.11.010_bb0100","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1440-1819.2010.02094.x","article-title":"Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models","volume":"64","author":"Watanabe","year":"2010","journal-title":"Psychiatry Clin. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910011507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910011507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:13:00Z","timestamp":1757974380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910011507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":20,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0014299910011507"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.11.010","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}