{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:46:11Z","timestamp":1744951571341},"reference-count":32,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ejphar.2010.11.020","type":"journal-article","created":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T04:41:07Z","timestamp":1291351267000},"page":"121-125","source":"Crossref","is-referenced-by-count":7,"title":["Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats"],"prefix":"10.1016","volume":"652","author":[{"given":"Tomohisa","family":"Iwai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Kida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinobu","family":"Goso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasaburo","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2010.11.020_bb0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF02774464","article-title":"Efficacy of anti-ulcer drugs on the recovery of gastric mucosal glycoproteins with aspirin-induced gastric damage in rat","volume":"16","author":"Azuumi","year":"1981","journal-title":"Gastroenterol. Jpn"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0010","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1016\/0006-2952(87)90562-4","article-title":"Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone","volume":"36","author":"Bilski","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10715760100300561","article-title":"Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes","volume":"35","author":"Dekigai","year":"2001","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0014-2999(82)90004-8","article-title":"Effects of geranylgeranylacetone on gastrointestinal secretion in rats","volume":"77","author":"Fujimoto","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1053\/gast.1996.v111.pm8690199","article-title":"Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa","volume":"111","author":"Hirakawa","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/bbrc.1998.8384","article-title":"Lipopolysaccharide activates endothelial nitric oxide synthase through protein tyrosine kinase","volume":"245","author":"Huang","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(94)90451-0","article-title":"Effects of acid-inhibitory antiulcer drugs on mucin biosynthesis in the rat stomach","volume":"251","author":"Ichikawa","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2220\/biomedres.23.63","article-title":"Immunohistchemical localization in rat gastrointestinal tract of a sialomucin species recognized by HCM31, a new anti-mucin monoclonal antibody","volume":"23","author":"Ikezawa","year":"2002","journal-title":"Biomed. Res."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1254\/jjp.41.117","article-title":"Increasing action of teprenone, a new antiulcer agent, on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats","volume":"41","author":"Ito","year":"1986","journal-title":"Jpn J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00535-009-0007-0","article-title":"Effects of indomethacin on the rat small intestinal mucosa: immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies","volume":"44","author":"Iwai","year":"2009","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0060","first-page":"25","article-title":"Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats","volume":"50","author":"Konaka","year":"1999","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0065","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.cgh.2007.04.031","article-title":"Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a cross-sectional capsule enteroscopy study","volume":"5","author":"Maiden","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0070","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/00365520701794121","article-title":"Prevalence of non-steroidal anti-inflammatory drug-induced enteropathy determined by double-balloon endoscopy: a Japanese multicenter study","volume":"43","author":"Matsumoto","year":"2008","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0075","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gut.2007.141481","article-title":"Secreted enteric antimicrobial activity localises to the mucus surface layer","volume":"57","author":"Meyer-Hoffert","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0080","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1023\/A:1026692920848","article-title":"Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells","volume":"44","author":"Mizushima","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0085","first-page":"799","article-title":"Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats","volume":"31","author":"Murakami","year":"1981","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1254\/jjp.32.299","article-title":"Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats","volume":"32","author":"Murakami","year":"1982","journal-title":"Jpn J. Pharmacol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0095","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/BF01296507","article-title":"Effects of antiulcer drugs on phosphatidylcholine synthesis in isolated guinea pig gastric glands","volume":"37","author":"Nishisaki","year":"1992","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0100","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/00365520510023161","article-title":"Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis","volume":"40","author":"Ohkawara","year":"2005","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0105","first-page":"229","article-title":"Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice","volume":"17","author":"Ohkawara","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF01082444","article-title":"Alternating laminated array of two types of mucin in the human gastric surface mucous layer","volume":"24","author":"Ota","year":"1992","journal-title":"Histochem. J."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0016-5085(97)70225-7","article-title":"Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation","volume":"112","author":"Reuter","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0016-5085(19)32433-3","article-title":"An intestinal disease produced experimentally by a prostaglandin deficiency","volume":"69","author":"Robert","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0125","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s005350070046","article-title":"Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase","volume":"35","author":"Rokutan","year":"2000","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0130","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1348-0421.2004.tb03625.x","article-title":"2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-beta production","volume":"48","author":"Sugiyama","year":"2004","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000064419","article-title":"Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats","volume":"66","author":"Takeuchi","year":"2002","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0140","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000199365","article-title":"Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa","volume":"35","author":"Terano","year":"1986","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0145","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1111\/j.1742-4658.2007.05731.x","article-title":"A monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen, on the carbohydrate moiety of mucin","volume":"274","author":"Tsubokawa","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0150","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.exppara.2009.08.008","article-title":"Nippostrongylus brasiliensis: increase of sialomucins reacting with anti-mucin monoclonal antibody HCM31 in rat small intestinal mucosa with primary infection and reinfection","volume":"123","author":"Tsubokawa","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejphar.2010.11.020_bb0155","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/gut.2007.125963","article-title":"Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent","volume":"57","author":"Watanabe","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000138047","article-title":"Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat","volume":"30","author":"Weissenborn","year":"1985","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2010.11.020_bb0165","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/cbf.1156","article-title":"Correlation of gastric mucosal damage with sialic acid profile in rats: effect of hydrochloric acid, pepsin and hypertonic saline","volume":"23","author":"Yusuf","year":"2005","journal-title":"Cell Biochem. Funct."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910011702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299910011702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T15:28:48Z","timestamp":1559834928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299910011702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":32,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0014299910011702"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2010.11.020","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}