{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:41:44Z","timestamp":1778589704357,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.ejphar.2011.01.048","type":"journal-article","created":{"date-parts":[[2011,2,5]],"date-time":"2011-02-05T09:23:05Z","timestamp":1296897785000},"page":"67-75","source":"Crossref","is-referenced-by-count":19,"title":["5-HT induces enhanced phrenic nerve activity via 5-HT2A receptor\/PKC mechanism in anesthetized rats"],"prefix":"10.1016","volume":"657","author":[{"given":"Jinping","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret T.T.","family":"Wong-Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2011.01.048_bb0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0034-5687(96)00017-5","article-title":"Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent","volume":"104","author":"Bach","year":"1996","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1152\/japplphysiol.00374.2002","article-title":"Plasticity in respiratory motor control selected contribution: intermittent hypoxia induces phrenic long-term facilitation in carotid body-denervated rats","volume":"94","author":"Bavis","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0015","doi-asserted-by":"crossref","first-page":"14470","DOI":"10.1073\/pnas.212517999","article-title":"Internalization and recycling of 5-HT2A receptors activated by serotonin and protein kinase C-mediated mechanisms","volume":"99","author":"Bhattacharyya","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.ejphar.2011.01.048_bb0020","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0034-5687(95)00045-F","article-title":"Neurotransmitters in the CNS control of breathing","volume":"101","author":"Bonham","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.resp.2008.06.021","article-title":"Pharmacology of vagal afferent influences on disordered breathing during sleep","volume":"164","author":"Carley","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0027715","article-title":"Afferent vagal C-fiber innervation of the lungs and airways and its functional significance","volume":"99","author":"Coleridge","year":"1984","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0035","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.neuro.26.041002.131103","article-title":"Breathing: rhythmicity, plasticity, chemosensitivity","volume":"26","author":"Feldman","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0034-5687(00)00124-9","article-title":"Long-term facilitation of phrenic motor output","volume":"121","author":"Fuller","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0045","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(97)89173-X","article-title":"Serotonergic modulation of central respiratory activity in the neonatal mouse: an in vitro study","volume":"329","author":"Hilaire","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.resp.2010.08.017","article-title":"The role of serotonin in respiratory function and dysfunction","volume":"174","author":"Hilaire","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuron.2004.07.011","article-title":"Serotonin regulates the secretion and autocrine action of a neuropeptide to activate MAPK required for long-term facilitation in Aplysia","volume":"43","author":"Hu","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2011.01.048_bb0060","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10024-005-0067-y","article-title":"Abnormalities of the brainstem serotonergic system in the sudden infant death syndrome: a review","volume":"8","author":"Kinney","year":"2005","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0065","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/BF02256323","article-title":"Supranodose vagotomy precludes reflex respiratory responses to serotonin in cats","volume":"10","author":"Kopczy\u0144ska","year":"2003","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0070","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.lfs.2004.03.029","article-title":"5HT2 and 5HT3 receptors' contribution to modeling of post-serotonin respiratory pattern in cats","volume":"75","author":"Kopczy\u0144ska","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1113\/jphysiol.1993.sp019510","article-title":"Modulation of respiratory activity of neonatal rat phrenic motoneurons by serotonin","volume":"461","author":"Lindsay","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0080","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1523\/JNEUROSCI.21-14-05381.2001","article-title":"Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing","volume":"21","author":"Ling","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1113\/expphysiol.2006.033720","article-title":"Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?","volume":"92","author":"Mahamed","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0090","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1113\/jphysiol.2007.149047","article-title":"Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats","volume":"586","author":"Mahamed","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0034-5687(80)90025-0","article-title":"Prolonged stimulation of respiration by a new central neural mechanism","volume":"41","author":"Millhorn","year":"1980","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/japplphysiol.00523.2002","article-title":"Neuroplasticity in respiratory motor control","volume":"94","author":"Mitchell","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0105","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1152\/jappl.2001.90.6.2466","article-title":"Invited review: intermittent hypoxia and respiratory plasticity","volume":"90","author":"Mitchell","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0110","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0006-8993(90)91611-J","article-title":"Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat","volume":"535","author":"Morin","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0115","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1113\/jphysiol.1992.sp019181","article-title":"Compared effects of serotonin on cervical and hypoglossal inspiratory activities: an in vitro study","volume":"451","author":"Morin","year":"1992","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0120","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1523\/JNEUROSCI.2803-06.2007","article-title":"Episodic stimulation of \u03b11-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability","volume":"27","author":"Neverova","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0125","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s004240050543","article-title":"Modulation of respiratory rhythm by 5-HT in the brainstem-spinal cord preparation from newborn rat","volume":"435","author":"Onimaru","year":"1998","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1113\/jphysiol.2006.116020","article-title":"5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase","volume":"576","author":"Peng","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0135","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1523\/JNEUROSCI.4768-08.2009","article-title":"NADPH-oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia","volume":"29","author":"Peng","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0140","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.molmed.2003.10.010","article-title":"Serotonin receptors: guardians of stable breathing","volume":"9","author":"Richter","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0145","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0306-4522(02)00540-7","article-title":"Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of perinatal rats","volume":"115","author":"Schwarzacher","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2011.01.048_bb0150","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00221-010-2161-2","article-title":"Microinjection of methysergide into the raphe nucleus attenuated phrenic long-term facilitation in rats","volume":"202","author":"Valic","year":"2010","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00210-007-0179-1","article-title":"Cardiovascular responses produced by 5-hydroxytriptamine: a pharmacological update on the receptors\/mechanisms involved and therapeutic implications","volume":"376","author":"Villal\u03ccn","year":"2007","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0160","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1523\/JNEUROSCI.5539-07.2008","article-title":"Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia","volume":"28","author":"Wilkerson","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2011.01.048_bb0165","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0022-3565(25)11383-9","article-title":"Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rats","volume":"260","author":"Yoshioka","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911001063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911001063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T11:30:18Z","timestamp":1740915018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299911001063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":33,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0014299911001063"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2011.01.048","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}