{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:36:26Z","timestamp":1790901386986,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.ejphar.2011.03.033","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T14:14:07Z","timestamp":1302272047000},"page":"244-251","source":"Crossref","is-referenced-by-count":34,"title":["A novel agonist of PPAR-\u03b3 based on barbituric acid alleviates the development of non-alcoholic fatty liver disease by regulating adipocytokine expression and preventing insulin resistance"],"prefix":"10.1016","volume":"659","author":[{"given":"Hao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2011.03.033_bb0005","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/pgmj.2005.042200","article-title":"Treatment of non-alcoholic fatty liver disease","volume":"82","author":"Adams","year":"2006","journal-title":"Postgraduate medical journal"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0010","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"The New England journal of medicine"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0015","doi-asserted-by":"crossref","first-page":"5468","DOI":"10.1073\/pnas.81.17.5468","article-title":"Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein","volume":"81","author":"Bernlohr","year":"1984","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0020","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/jhep.2002.30692","article-title":"NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome","volume":"35","author":"Chitturi","year":"2002","journal-title":"Hepatology (Baltimore MD)"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2036.2006.02751.x","article-title":"Review article: drug therapy for non-alcoholic fatty liver disease","volume":"23","author":"Comar","year":"2006","journal-title":"Alimentary pharmacology & therapeutics"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0030","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0035","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1478-3231.2007.01497.x","article-title":"The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats","volume":"27","author":"Deng","year":"2007","journal-title":"Liver Int"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0040","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1259\/0007-1285-65-777-774","article-title":"Fatty infiltration of the liver: analysis of prevalence, radiological and clinical features and influence on patient management","volume":"65","author":"el-Hassan","year":"1992","journal-title":"The British journal of radiology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0045","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1440-1746.2003.02989.x","article-title":"Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?","volume":"18","author":"Farrell","year":"2003","journal-title":"Journal of gastroenterology and hepatology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0050","first-page":"271","article-title":"Mechanisms of action of thiazolidinediones","volume":"27","author":"Girard","year":"2001","journal-title":"Diabetes & metabolism"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0055","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2337\/diabetes.50.5.1126","article-title":"Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys","volume":"50","author":"Hotta","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0060","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.3748\/wjg.14.2888","article-title":"Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease","volume":"14","author":"Huang","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0065","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1073\/pnas.93.12.5793","article-title":"Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes","volume":"93","author":"Kallen","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0070","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/ajcn\/79.3.502","article-title":"Model of nonalcoholic steatohepatitis","volume":"79","author":"Lieber","year":"2004","journal-title":"The American journal of clinical nutrition"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0378-1119(96)00730-5","article-title":"Analysis of an expression profile of genes in the human adipose tissue","volume":"190","author":"Maeda","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0080","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.2337\/diabetes.50.9.2094","article-title":"PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein","volume":"50","author":"Maeda","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0085","doi-asserted-by":"crossref","first-page":"671","DOI":"10.7326\/0003-4819-130-8-199904200-00014","article-title":"The role of leptin in human obesity and disease: a review of current evidence","volume":"130","author":"Mantzoros","year":"1999","journal-title":"Annals of internal medicine"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/01.mol.0000174153.53683.f2","article-title":"Nonalcoholic fatty liver disease and the metabolic syndrome","volume":"16","author":"Marchesini","year":"2005","journal-title":"Current opinion in lipidology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0095","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1054\/mehy.1997.0682","article-title":"High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes","volume":"52","author":"McCarty","year":"1999","journal-title":"Medical hypotheses"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0105","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/sj.ijo.0800770","article-title":"Adipose tissue as an endocrine and paracrine organ","volume":"22","author":"Mohamed-Ali","year":"1998","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0110","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1053\/jhep.2003.50420","article-title":"Improved nonalcoholic steatohepatitis after 48weeks of treatment with the PPAR-gamma ligand rosiglitazone","volume":"38","author":"Neuschwander-Tetri","year":"2003","journal-title":"Hepatology (Baltimore Md)"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0115","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1440-1746.2004.03362.x","article-title":"Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men","volume":"19","author":"Park","year":"2004","journal-title":"Journal of gastroenterology and hepatology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0120","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.gastro.2008.03.078","article-title":"Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial","volume":"135","author":"Ratziu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0125","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3748\/wjg.v11.i37.5874","article-title":"Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?","volume":"11","author":"Sargin","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0130","first-page":"G894","article-title":"Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis","volume":"293","author":"Song","year":"2007","journal-title":"American journal of physiology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0135","doi-asserted-by":"crossref","first-page":"E969","DOI":"10.1152\/ajpendo.00497.2007","article-title":"A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels","volume":"294","author":"Stefanovic-Racic","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0140","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1016\/j.bmcl.2008.08.028","article-title":"New PPARgamma ligands based on barbituric acid: virtual screening, synthesis and receptor binding studies","volume":"18","author":"Sundriyal","year":"2008","journal-title":"Bioorganic & medicinal chemistry letters"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0145","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1124\/jpet.107.135822","article-title":"NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet","volume":"325","author":"Tanaka","year":"2008","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0150","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1111\/j.1572-0241.2000.03297.x","article-title":"Serum leptin levels in patients with nonalcoholic steatohepatitis","volume":"95","author":"Uygun","year":"2000","journal-title":"The American journal of gastroenterology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0155","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/01.mcg.0000152747.79773.2f","article-title":"Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study","volume":"39","author":"Vuppalanchi","year":"2005","journal-title":"Journal of clinical gastroenterology"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0160","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/oby.2005.93","article-title":"Differential expression of the peripheral benzodiazepine receptor and gremlin during adipogenesis","volume":"13","author":"Wade","year":"2005","journal-title":"Obesity research"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0165","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s007740300026","article-title":"Decrease in serum leptin by troglitazone is associated with preventing bone loss in type 2 diabetic patients","volume":"21","author":"Watanabe","year":"2003","journal-title":"Journal of bone and mineral metabolism"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0170","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1074\/jbc.M807120200","article-title":"Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways","volume":"284","author":"Watanabe","year":"2009","journal-title":"The Journal of biological chemistry"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI200317797","article-title":"The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice","volume":"112","author":"Xu","year":"2003","journal-title":"The Journal of clinical investigation"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0180","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nature medicine"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0185","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","article-title":"Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase","volume":"8","author":"Yamauchi","year":"2002","journal-title":"Nature medicine"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0190","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1053\/meta.2002.34715","article-title":"Effects of berberine on glucose metabolism in vitro","volume":"51","author":"Yin","year":"2002","journal-title":"Metabolism: clinical and experimental"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0195","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s11596-007-0308-6","article-title":"Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes","volume":"27","author":"Yin","year":"2007","journal-title":"Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0200","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJMra041001","article-title":"Thiazolidinediones","volume":"351","author":"Yki-Jarvinen","year":"2004","journal-title":"The New England journal of medicine"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0205","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.2337\/diabetes.51.10.2968","article-title":"The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects","volume":"51","author":"Yu","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2011.03.033_bb0210","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.lfs.2006.03.021","article-title":"High-fat emulsion-induced rat model of nonalcoholic steatohepatitis","volume":"79","author":"Zou","year":"2006","journal-title":"Life sciences"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911003451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911003451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T17:36:27Z","timestamp":1560101787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299911003451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":42,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0014299911003451"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2011.03.033","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}