{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:40:52Z","timestamp":1788446452508,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30973925"],"award-info":[{"award-number":["30973925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.ejphar.2011.04.015","type":"journal-article","created":{"date-parts":[[2011,4,30]],"date-time":"2011-04-30T14:42:57Z","timestamp":1304174577000},"page":"438-444","source":"Crossref","is-referenced-by-count":73,"title":["Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis"],"prefix":"10.1016","volume":"660","author":[{"given":"Yingbo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanying","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingcai","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2011.04.015_bb0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00432-009-0703-4","article-title":"Changes in expression, and\/or mutations in TGF-beta receptors (TGF-beta RI and TGF-beta RII) and Smad 4 in human ovarian tumors","volume":"36","author":"Antony","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00019606-200603000-00009","article-title":"Validation of the 2-deltadeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts","volume":"15","author":"Arocho","year":"2006","journal-title":"Diagn. Mol. Pathol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0015","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/MCG.0b013e31815cff36","article-title":"Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C","volume":"42","author":"Bares","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0020","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/labinvest.3700094","article-title":"Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis","volume":"84","author":"Borkham-Kamphorst","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0016-5085(98)70380-4","article-title":"Treatment of fibrosing cholestatic hepatitis with lamivudine","volume":"115","author":"Chan","year":"1998","journal-title":"Gastroenterology"},{"issue":"880","key":"10.1016\/j.ejphar.2011.04.015_bb0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.1999.tb09507.x","article-title":"Tumor suppressor gene Smad4\/DPC4, its downstream target genes, and regulation of cell cycle","volume":"30","author":"Chiao","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0035","first-page":"583","article-title":"The anti-fibrotic effect of liver growth factor is associated with decreased intrahepatic levels of matrix metalloproteinases 2 and 9 and transforming growth factor beta 1 in bile duct-ligated rats","volume":"23","author":"D\u00edaz-Gil","year":"2008","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/08977190109001078","article-title":"Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system","volume":"19","author":"Fibbi","year":"2001","journal-title":"Growth Factors"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0045","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2036.2010.04503.x","article-title":"Silymarin use and liver disease progression in the hepatitis c antiviral long-term treatment against cirrhosis trial","volume":"33","author":"Freedman","year":"2011","journal-title":"Aliment Pharmacol Ther."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/MEG.0b013e328318ed19","article-title":"Gastrointestinal symptoms in patients with liver cirrhosis are linked to impaired quality of life and psychological distress","volume":"21","author":"Fritz","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0055","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/mol.107.039818","article-title":"Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation","volume":"73","author":"Fu","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0060","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2009.12.009","article-title":"Fibrillar collagen scoring by second harmonic microscopy: a new tool in the assessment of liver fibrosis","volume":"52","author":"Gailhouste","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0065","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1007\/s00268-010-0655-5","article-title":"Prognostic impact of underlying liver fibrosis and cirrhosis after curative resection of hepatocellular carcinoma","volume":"34","author":"Gassmann","year":"2010","journal-title":"World J. Surg."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2002-26761","article-title":"Oxidative stress, plant-derived antioxidants and liver fibrosis","volume":"68","author":"Gebhardt","year":"2002","journal-title":"Planta. Med."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0075","doi-asserted-by":"crossref","first-page":"12719","DOI":"10.1073\/pnas.96.22.12719","article-title":"In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis","volume":"96","author":"George","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0080","first-page":"173","article-title":"Mast cell density, hepatic stellate cell activation and TGF-beta1 transcripts in the aging Sprague\u2013Dawley rat during early acute liver injury","volume":"31","author":"Grizzi","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1440-1746.2006.04361.x","article-title":"Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis","volume":"22","author":"Hsu","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.phrs.2008.06.011","article-title":"Defining therapeutic targets for liver fibrosis: exploiting the biology of inflammation and repair","volume":"58","author":"Iredale","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0095","doi-asserted-by":"crossref","first-page":"22089","DOI":"10.1074\/jbc.M700998200","article-title":"Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro","volume":"282","author":"Jackson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2119\/molmed.2009.00109","article-title":"Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction","volume":"16","author":"Jackson","year":"2010","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0105","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/1479-7364-4-3-194","article-title":"Update of human and mouse matrix metalloproteinase families","volume":"4","author":"Jackson","year":"2010","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.hepres.2004.04.006","article-title":"Transforming growth factor-beta-induced stimulation of formation of collagen fiber network and anti-fibrotic effect of taurine in an in vitro model of hepatic fibrosis","volume":"30","author":"Kato","year":"2004","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0115","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<330::AID-PATH765>3.0.CO;2-7","article-title":"Extracellular matrix composition and integrin expression in early hepatocarcinogenesis in human cirrhotic liver","volume":"181","author":"Le Bail","year":"1997","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0120","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/BF02980084","article-title":"Identification of expressed sequence tags of genes expressed highly in the activated hepatic stellate cell","volume":"27","author":"Lee","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00535-008-2180-y","article-title":"Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies","volume":"43","author":"Li","year":"2008","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbrc.2009.05.084","article-title":"The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis","volume":"386","author":"Li","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1478-3231.2005.01192.x","article-title":"Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis","volume":"26","author":"Liu","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jep.2009.12.038","article-title":"Herb medicine Gan-fu-kang attenuates liver injury in a rat fibrotic model","volume":"128","author":"Lou","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0145","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s00436-010-2014-8","article-title":"Silymarin treatment reduces granuloma and hepatic fibrosis in experimental schistosomiasis","volume":"107","author":"Mata-Santos","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0150","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/hep.23421","article-title":"Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans","volume":"51","author":"Moreno","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0155","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1016\/j.transproceed.2005.10.104","article-title":"Cyclosporine suppresses cell growth and collagen production in hepatic stellate cells","volume":"37","author":"Nakamuta","year":"2005","journal-title":"Transplant Proc."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0160","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1126\/science.1137603","article-title":"Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR","volume":"315","author":"Passino","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.alcohol.2004.06.008","article-title":"Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium","volume":"34","author":"Purohit","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/0970-9290.29870","article-title":"Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis","volume":"17","author":"Rajendran","year":"2006","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0175","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1136\/gut.2003.027516","article-title":"Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis","volume":"53","author":"Sato","year":"2004","journal-title":"Gut."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0180","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3727\/000000003108747064","article-title":"Establishment of an immortalized human hepatic stellate cell line to develop antifibrotic therapies","volume":"12","author":"Shibata","year":"2003","journal-title":"Cell Transplant"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0185","first-page":"61","article-title":"S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats","volume":"55","author":"Shinkawa","year":"2009","journal-title":"Osaka City Med. J."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0190","first-page":"2272","article-title":"Inhibitory effect of blocking TGF-beta\/Smad signal on injury-induced fibrosis of corneal endothelium","volume":"14","author":"Sumioka","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0195","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jep.2010.05.038","article-title":"Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1\/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells","volume":"130","author":"Tien","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0200","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1053\/jhep.2003.50196","article-title":"Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis","volume":"37","author":"Ueberham","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2011.04.015_bb0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(02)03276-3","article-title":"p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1)","volume":"528","author":"Varela-Rey","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0210","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1074\/jbc.274.8.4570","article-title":"Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members","volume":"274","author":"Velasco","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0215","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1023\/A:1026630129025","article-title":"Plasma levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and TIMP-2) as noninvasive markers of liver disease in chronic hepatitis C: comparison using ROC analysis","volume":"44","author":"Walsh","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0220","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neulet.2005.05.069","article-title":"Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action","volume":"386","author":"Wei","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0225","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/A:1020822610085","article-title":"Potential role of regucalcin as a specific biochemical marker of chronic liver injury with carbon tetrachloride administration in rats","volume":"241","author":"Yamaguchi","year":"2002","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.ejphar.2011.04.015_bb0230","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","article-title":"Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors","volume":"124","author":"Yang","year":"2003","journal-title":"Gastroenterology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911004055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911004055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T14:53:47Z","timestamp":1592492027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299911004055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":46,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0014299911004055"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2011.04.015","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}