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Microbiol."},{"key":"10.1016\/j.ejphar.2011.07.013_bb0650","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1750-3639.2000.tb00248.x","article-title":"Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation","volume":"10","author":"Stanimirovic","year":"2000","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ejphar.2011.07.013_bb0655","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1177\/039463200902200401","article-title":"Autism spectrum disorders and mastocytosis","volume":"22","author":"Theoharides","year":"2009","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.07.013_bb0660","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tips.2004.09.007","article-title":"Mast cells as targets of corticotropin-releasing factor and related peptides","volume":"25","author":"Theoharides","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2011.07.013_bb0665","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/sj.mp.4001077","article-title":"Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism","volume":"7","author":"Torrente","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejphar.2011.07.013_bb0670","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.2003.tb00648.x","article-title":"Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2","volume":"35","author":"Vadeboncoeur","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.ejphar.2011.07.013_bb0675","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nri824","article-title":"The future of antigen-specific immunotherapy of allergy","volume":"2","author":"Valenta","year":"2002","journal-title":"Nat. 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