{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:22:48Z","timestamp":1791145368162,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["9930016N"],"award-info":[{"award-number":["9930016N"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ejphar.2011.08.005","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T13:16:05Z","timestamp":1315055765000},"page":"105-113","source":"Crossref","is-referenced-by-count":19,"title":["Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2\/Dihydropyridine insensitive and Cav2.1\/Dihydropyridine sensitive"],"prefix":"10.1016","volume":"670","author":[{"given":"Min","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluyemi","family":"Aladejebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Hockerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2011.08.005_bb0005","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1021\/jm00159a022","article-title":"Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents","volume":"29","author":"Arrowsmith","year":"1986","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0010","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1021\/jm00051a017","article-title":"Interaction of calcium channel antagonists with calcium: structural studies on nicardipine and its Ca2+ complex","volume":"37","author":"Belciug","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0015","first-page":"110","article-title":"Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors","volume":"9","author":"Burges","year":"1987","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0020","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1021\/jm061245a","article-title":"Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations","volume":"50","author":"Cosconati","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0025","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1124\/mol.64.2.491","article-title":"Molecular determinants of Ca2+ potentiation of diltiazem block and Ca2+-dependent inactivation in the pore region of cav1.2","volume":"64","author":"Dilmac","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0030","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1126\/science.2458626","article-title":"Sequence and expression of mrnas encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel","volume":"241","author":"Ellis","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0035","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-3565(24)35127-4","article-title":"Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes","volume":"291","author":"Furukawa","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0040","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/anie.199115591","article-title":"1,4 Dihydropyridines: effects of chirality and conformation on the calcium antagonist and calicum agonist activities","volume":"30","author":"Goldman","year":"1991","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0045","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1021\/jm00096a005","article-title":"Determination of the absolute configuration of the active amlodipine enantiomer as (\u2212)-S: a correction","volume":"35","author":"Goldmann","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.37.1.361","article-title":"Molecular determinants of drug binding and action on l-type calcium channels","volume":"37","author":"Hockerman","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0055","doi-asserted-by":"crossref","first-page":"14906","DOI":"10.1073\/pnas.94.26.14906","article-title":"Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-l-type Ca2+ channel","volume":"94","author":"Hockerman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0060","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1124\/mol.58.6.1264","article-title":"Molecular determinants of diltiazem block in domains IIIS6 and IVS6 of L-type Ca2+ channels","volume":"58","author":"Hockerman","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0065","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1476-5381.1993.tb13540.x","article-title":"The action of amlodipine on voltage-operated calcium channels in vascular smooth muscle","volume":"109","author":"Hughes","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0070","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejphar.2008.11.051","article-title":"Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs","volume":"602","author":"Hui","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0075","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1124\/mol.52.4.735","article-title":"Transfer of the high affinity dihydropyridine sensitivity from l-type to non-l-type calcium channel","volume":"52","author":"Ito","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0080","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1248\/cpb.27.1426","article-title":"Synthesis of new water-soluble dihydropyridine vasodilators","volume":"27","author":"Iwanami","year":"1979","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1681.1984.tb00233.x","article-title":"Secretory and vascular effects of the optical isomers of nicardipine","volume":"11","author":"Iwatsuki","year":"1984","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1021977304001","article-title":"Overview of voltage-dependent calcium channels","volume":"30","author":"Jones","year":"1998","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0095","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1085\/jgp.93.6.1109","article-title":"Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor","volume":"93","author":"Kass","year":"1989","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0100","doi-asserted-by":"crossref","first-page":"35I","DOI":"10.1016\/0002-9149(89)90958-2","article-title":"Cellular electrophysiology of amlodipine: probing the cardiac L-type calcium channel","volume":"64","author":"Kass","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1085\/jgp.98.1.63","article-title":"Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium","volume":"98","author":"Kass","year":"1991","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0110","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/01.RES.67.2.469","article-title":"Actions of Ca2+ antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture","volume":"67","author":"Kuga","year":"1990","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0115","first-page":"153","article-title":"Isradipine interacts with the open state of the L-type calcium channel at high concentrations","volume":"6","author":"Lacinova","year":"1998","journal-title":"Receptors Channels"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0120","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0022-3565(24)38294-1","article-title":"Distinctions in the molecular determinants of charged and neutral dihydropyridine block of l-type calcium channels","volume":"289","author":"Lacinova","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0125","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/302790a0","article-title":"Mechanism of calcium channel blockade by verapamil, d600, diltiazem and nitrendipine in single dialysed heart cells","volume":"302","author":"Lee","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0130","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1124\/mol.55.1.134","article-title":"A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel","volume":"55","author":"Li","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0135","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1124\/jpet.102.046334","article-title":"Ca(v)1.3 is preferentially coupled to glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1","volume":"305","author":"Liu","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0140","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1021933504909","article-title":"Molecular basis of drug interaction with L-type Ca2+ channels","volume":"30","author":"Mitterdorfer","year":"1998","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejphar.2010.01.006","article-title":"A region of N-type Ca2+ channel critical for blockade by the dihydropyridine amlodipine","volume":"632","author":"Miyashita","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0014-5793(91)81296-K","article-title":"Cloning and tissue-specific expression of the brain calcium channel beta-subunit","volume":"291","author":"Pragnell","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0155","doi-asserted-by":"crossref","first-page":"27686","DOI":"10.1074\/jbc.272.44.27686","article-title":"Nine l-type amino acid residues confer full 1,4-dihydropyridine sensitivity to the neuronal calcium channel alpha1a subunit. Role of l-type met1188","volume":"272","author":"Sinnegger","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(91)90073-9","article-title":"Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian cns","volume":"7","author":"Snutch","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0165","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1073\/pnas.88.13.5621","article-title":"Primary structure of a calcium channel that is highly expressed in the rat cerebellum","volume":"88","author":"Starr","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ejphar.2011.08.005_bb0170","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0165-6147(98)01171-7","article-title":"Structural basis of drug binding to l Ca2+ channels","volume":"19","author":"Striessnig","year":"1998","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2007.02.049","article-title":"Adenoviral-mediated expression of dihydropyridine-insensitive L-type calcium channels in cardiac ventricular myocytes and fibroblasts","volume":"565","author":"Walsh","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.08.005_bb0180","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0306-3623(96)00367-9","article-title":"Inhibition of voltage-dependent Ca2+ channels of porcine tracheal smooth muscle by the novel Ca2+ channel antagonist RWJ-22108","volume":"28","author":"Yamakage","year":"1997","journal-title":"Gen. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911008946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911008946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T18:51:39Z","timestamp":1741546299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299911008946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0014299911008946"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2011.08.005","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}