{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:56:15Z","timestamp":1780552575968,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK084284"],"award-info":[{"award-number":["DK084284"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK083687"],"award-info":[{"award-number":["DK083687"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ejphar.2011.08.013","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T04:30:58Z","timestamp":1315024258000},"page":"252-259","source":"Crossref","is-referenced-by-count":38,"title":["Large conductance Ca2+-activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle"],"prefix":"10.1016","volume":"670","author":[{"given":"Rupal P.","family":"Soder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgi V.","family":"Petkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2011.08.013_bb0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1474-4422(03)00622-7","article-title":"Antimuscarinics for treatment of overactive bladder","volume":"3","author":"Andersson","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0010","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1152\/physrev.00038.2003","article-title":"Urinary bladder contraction and relaxation: physiology and pathophysiology","volume":"84","author":"Andersson","year":"2004","journal-title":"Physiol Rev"},{"issue":"Suppl 2","key":"10.1016\/j.ejphar.2011.08.013_bb0015","doi-asserted-by":"crossref","first-page":"120P","DOI":"10.1016\/S0021-5198(19)59903-6","article-title":"Ion channels and control of contractile activity in urinary bladder smooth muscle","volume":"58","author":"Brading","year":"1992","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0090-4295(97)00591-8","article-title":"A myogenic basis for the overactive bladder","volume":"50","author":"Brading","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1476-5381.1990.tb12956.x","article-title":"Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: effects of atropine and alpha, beta-methylene ATP","volume":"99","author":"Brading","year":"1990","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0030","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.1074\/jbc.275.9.6453","article-title":"Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4","volume":"275","author":"Brenner","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0035","doi-asserted-by":"crossref","first-page":"F1149","DOI":"10.1152\/ajprenal.00440.2007","article-title":"Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+channel","volume":"295","author":"Brown","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0040","doi-asserted-by":"crossref","first-page":"F1416","DOI":"10.1152\/ajprenal.00595.2009","article-title":"Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein","volume":"298","author":"Chang","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0045","doi-asserted-by":"crossref","first-page":"R177","DOI":"10.1152\/ajpregu.00036.2010","article-title":"Voltage-gated K(+) channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle","volume":"299","author":"Chen","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0050","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.juro.2009.02.109","article-title":"Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle","volume":"182","author":"Chen","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0055","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/j.1476-5381.1994.tb17171.x","article-title":"Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle","volume":"113","author":"Edwards","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0060","doi-asserted-by":"crossref","first-page":"C110","DOI":"10.1152\/ajpcell.1997.273.1.C110","article-title":"Ca(2+)-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle","volume":"273","author":"Heppner","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0065","doi-asserted-by":"crossref","first-page":"R402","DOI":"10.1152\/ajpregu.00488.2004","article-title":"Negative feedback regulation of nerve-mediated contractions by KCa channels in mouse urinary bladder smooth muscle","volume":"289","author":"Herrera","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0070","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1152\/ajpregu.2000.279.1.R60","article-title":"Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels","volume":"279","author":"Herrera","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0075","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1476-5381.1996.tb15163.x","article-title":"Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle","volume":"117","author":"Holland","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0080","series-title":"Large conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function","author":"Hristov","year":"2011"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0085","doi-asserted-by":"crossref","first-page":"C1344","DOI":"10.1152\/ajpcell.00001.2008","article-title":"Stimulation of beta3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channels","volume":"295","author":"Hristov","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-2999(97)00102-7","article-title":"NS 1619 activates Ca2+-activated K+ currents in rat vas deferens","volume":"325","author":"Huang","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0095","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1476-5381.1993.tb13593.x","article-title":"Functional importance of cholinergic and purinergic neurotransmission for micturition contraction in the normal, unanaesthetized rat","volume":"109","author":"Igawa","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0100","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1365-201X.2001.00908.x","article-title":"Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle","volume":"173","author":"Imai","year":"2001","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0105","doi-asserted-by":"crossref","first-page":"R1310","DOI":"10.1152\/ajpregu.00523.2009","article-title":"Effects of bladder outlet obstruction on properties of Ca2+-activated K+ channels in rat bladder","volume":"298","author":"Kita","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0110","doi-asserted-by":"crossref","first-page":"R378","DOI":"10.1152\/ajpregu.00458.2009","article-title":"BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle","volume":"298","author":"Layne","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0115","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1111\/j.1476-5381.1995.tb16387.x","article-title":"A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture","volume":"116","author":"Macmillan","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0120","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00210-004-0920-y","article-title":"Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle","volume":"369","author":"Malysz","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0125","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1073\/pnas.100118597","article-title":"A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin","volume":"97","author":"Meera","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0130","doi-asserted-by":"crossref","first-page":"36746","DOI":"10.1074\/jbc.M405621200","article-title":"Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel","volume":"279","author":"Meredith","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0135","doi-asserted-by":"crossref","first-page":"R1049","DOI":"10.1152\/ajpregu.00236.2006","article-title":"Muscarinic regulation of neonatal rat bladder spontaneous contractions","volume":"291","author":"Ng","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0140","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1464-410X.2010.09935.x","article-title":"Effects of Potassium Channel Modulators on Myogenic Spontaneous Phasic Contractile Activity in Human Detrusor from Neurogenic Patients","volume":"108","author":"Oger","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0145","series-title":"Chapter 16 in Pharmacology: Principles and Practice","first-page":"385","article-title":"Ion channels","author":"Petkov","year":"2009"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0150","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1469-7793.2001.00443.x","article-title":"Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle","volume":"537","author":"Petkov","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0155","doi-asserted-by":"crossref","first-page":"R1427","DOI":"10.1152\/ajpregu.2001.280.5.R1427","article-title":"Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder","volume":"280","author":"Petkov","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0160","doi-asserted-by":"crossref","first-page":"C1255","DOI":"10.1152\/ajpcell.00381.2004","article-title":"Differential regulation of Ca2+-activated K+ channels by beta-adrenoceptors in guinea pig urinary bladder smooth muscle","volume":"288","author":"Petkov","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0165","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrn1992","article-title":"High-conductance potassium channels of the SLO family","volume":"7","author":"Salkoff","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0170","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0022-3565(24)37136-8","article-title":"Inhibition of guinea pig detrusor contraction by NS-1619 is associated with activation of BKCa and inhibition of calcium currents","volume":"283","author":"Sheldon","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s002320001007","article-title":"Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder","volume":"173","author":"Siemer","year":"2000","journal-title":"J Membr Biol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0180","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00345-002-0301-4","article-title":"Prevalence and burden of overactive bladder in the United States","volume":"20","author":"Stewart","year":"2003","journal-title":"World J Urol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0185","doi-asserted-by":"crossref","first-page":"F604","DOI":"10.1152\/ajprenal.00060.2005","article-title":"Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder","volume":"289","author":"Thorneloe","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0190","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/bbrc.1995.2146","article-title":"Calcium dependent K-channels in guinea pig and human urinary bladder","volume":"213","author":"Trivedi","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0195","doi-asserted-by":"crossref","first-page":"R616","DOI":"10.1152\/ajpregu.00036.2006","article-title":"Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels","volume":"292","author":"Werner","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ejphar.2011.08.013_bb0200","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/sj.bjp.0703885","article-title":"BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery","volume":"132","author":"Yamamura","year":"2001","journal-title":"Br J Pharmacol"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911009022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911009022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T18:29:29Z","timestamp":1741544969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299911009022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0014299911009022"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2011.08.013","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}