{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:12:53Z","timestamp":1791051173111,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.ejphar.2011.12.029","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T22:01:31Z","timestamp":1325196091000},"page":"102-106","source":"Crossref","is-referenced-by-count":8,"title":["Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes"],"prefix":"10.1016","volume":"677","author":[{"given":"Luis G.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique J.","family":"Cobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Baeyens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2011.12.029_bb0005","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1046\/j.1471-4159.1995.64062544.x","article-title":"Pharmacological characterization of the voltage-dependent Ca2+ channels present in synaptosomes from rat and chicken central nervous system","volume":"64","author":"Alvarez Maubecin","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0010","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0026-895X(25)10504-X","article-title":"Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)","volume":"48","author":"Bezprozvanny","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0031-6865(99)00034-5","article-title":"Sigma receptors: recent advances and new clinical potentials","volume":"74","author":"Bowen","year":"2000","journal-title":"Pharm. Acta Helv."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0030","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0304-3940(96)12711-7","article-title":"Intrasynaptosomal free calcium levels in rat forebrain synaptosomes: modulation by sigma (\u03c3) receptor ligands","volume":"211","author":"Brent","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0025","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1046\/j.1471-4159.1997.68052201.x","article-title":"Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: modulation by the sigma ligand, 1,3-ditolylguanidine","volume":"68","author":"Brent","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2005.01.036","article-title":"Formalin-induced pain is reduced in \u03c31 receptor knockout mice","volume":"511","author":"Cend\u00e1n","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0040","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11068-007-9010-7","article-title":"Beta-amyloid enhances intracellular calcium rises mediated by repeated activation of intracellular calcium stores and nicotinic receptors in acutely dissociated rat basal forebrain neurons","volume":"35","author":"Chin","year":"2006","journal-title":"Brain Cell Biol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0045","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1111\/j.1476-5381.1995.tb15929.x","article-title":"Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones","volume":"116","author":"Church","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0050","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1471-4159.2007.04533.x","article-title":"Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells","volume":"102","author":"Cobos","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2174\/157015908787386113","article-title":"Pharmacology and therapeutic potential of sigma-1 receptor ligands","volume":"6","author":"Cobos","year":"2008","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0195","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pain.2009.05.013","article-title":"Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury","volume":"145","author":"de la Puente","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2011.12.029_bb0065","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.bjp.0703300","article-title":"Modulation of the dinucleotide receptor present in rat midbrain synaptosomes by adenosine and ATP","volume":"130","author":"D\u00edaz-Hern\u00e1ndez","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0070","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.pain.2009.03.011","article-title":"Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice","volume":"143","author":"Entrena","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2011.12.029_bb0075","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00210-002-0629-8","article-title":"Ca2+ entry via P\/Q-type Ca2+ channels and the Na+\/Ca2+ exchanger in rat and human neocortical synaptosomes","volume":"366","author":"Fink","year":"2002","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0014-2999(01)00932-3","article-title":"Changes in [3H]glibenclamide binding to mouse forebrain membranes during morphine tolerance","volume":"418","author":"Gonz\u00e1lez","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0085","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0090","doi-asserted-by":"crossref","first-page":"8072","DOI":"10.1073\/pnas.93.15.8072","article-title":"Purification, molecular cloning, and expression of the mammalian sigma-1 binding site","volume":"93","author":"Hanner","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0100","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2011.12.029_bb0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1517\/14728222.12.1.45","article-title":"An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma-1 receptor ligand","volume":"12","author":"Hayashi","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2011.12.029_bb0095","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-3565(24)39299-7","article-title":"Ca2+ signaling via \u03c31 receptors: novel regulatory mechanism affecting intracellular Ca2+ concentration","volume":"293","author":"Hayashi","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-8993(95)01103-X","article-title":"Role of calcium in sigma-mediated neuroprotection in rat primary cortical neurons","volume":"704","author":"Klette","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0115","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1046\/j.1460-9568.2003.02950.x","article-title":"Generation and phenotypic analysis of sigma receptor type I (\u03c31) knockout mice","volume":"18","author":"Langa","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0120","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.neuro.2007.01.005","article-title":"Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons","volume":"28","author":"Marino","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ejphar.2011.12.029_bb0125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0014-2999(95)00208-3","article-title":"Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism","volume":"280","author":"Matsumoto","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0130","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pharmthera.2009.07.001","article-title":"The pharmacology of sigma-1 receptors","volume":"124","author":"Maurice","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0135","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/PL00005120","article-title":"Involvement of different calcium channels in K+- and veratridine-induced increases of cytosolic calcium concentration in rat cerebral cortical synaptosomes","volume":"356","author":"Meder","year":"1997","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0140","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0022-3565(24)35014-1","article-title":"Calcium channels involved in K+- and veratridine-induced increase of cytosolic calcium concentration in human cerebral cortical synaptosomes","volume":"290","author":"Meder","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0145","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1021\/jm990135j","article-title":"Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N, N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover \u03c31 ligands","volume":"42","author":"Nakazato","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ceca.2004.06.007","article-title":"Ca2+ clearance mechanisms in neurohypophysial terminals of the rat","volume":"37","author":"Sasaki","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2011.12.029_bb0155","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0022-3565(25)20283-X","article-title":"Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand","volume":"259","author":"Su","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0160","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/physrev.1999.79.4.1089","article-title":"Measurement of intracellular calcium","volume":"79","author":"Takahashi","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0165","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/BF00233243","article-title":"Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes","volume":"351","author":"Tanaka","year":"1995","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0197-0186(92)90041-O","article-title":"Rapid kinetics of depolarization-induced changes in intrasynaptosomal calcium concentrations","volume":"20","author":"Tareilus","year":"1992","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0175","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1167\/iovs.08-1867","article-title":"Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction","volume":"49","author":"Tchedre","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0180","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1871524910909030184","article-title":"Sigma-1 receptor chaperones and diseases","volume":"9","author":"Tsai","year":"2009","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0185","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/jnr.490320215","article-title":"Advances in the use of the fluorescent probe fura-2 for the estimation of intrasynaptosomal calcium","volume":"32","author":"Yates","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2011.12.029_bb0190","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1152\/jn.2002.87.6.2867","article-title":"Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons","volume":"87","author":"Zhang","year":"2002","journal-title":"J. Neurophysiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911015639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299911015639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:05:32Z","timestamp":1742180732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299911015639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":38,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0014299911015639"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2011.12.029","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}