{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:59:13Z","timestamp":1792112353008,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.ejphar.2012.03.003","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T23:16:27Z","timestamp":1331939787000},"page":"161-165","source":"Crossref","is-referenced-by-count":17,"title":["Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward"],"prefix":"10.1016","volume":"683","author":[{"given":"Erik B.","family":"Oleson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.","family":"Espa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Harp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2012.03.003_bb0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00213-009-1555-y","article-title":"Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys","volume":"205","author":"Banks","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0010","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0166-2236(03)00233-9","article-title":"Parsing reward","volume":"26","author":"Berridge","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1126\/science.166.3907.899","article-title":"Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action","volume":"166","author":"Coyle","year":"1969","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0020","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0025","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/PL00005274","article-title":"Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade","volume":"358","author":"Dringenberg","year":"1998","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0030","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.2042-7158.1970.tb08420.x","article-title":"Effect of some antiparkinsonian drugs on catecholamine neurons","volume":"22","author":"Farnebo","year":"1970","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1000","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2009.11.003","article-title":"The role of antihistaminic effects in the misuse of quetiapine: a case report and review of the literature","volume":"34","author":"Fischer","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0035","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0306-4522(03)00005-8","article-title":"A role for presynaptic mechanisms in the actions of nomifensine and haloperidol","volume":"118","author":"Garris","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0040","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.addbeh.2004.06.018","article-title":"Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence","volume":"29","author":"Grabowski","year":"2004","journal-title":"Addict. Behav."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0149-7634(01)00038-0","article-title":"Mechanisms and abuse liability of the anti-histamine dimenhydrinate","volume":"26","author":"Halpert","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0050","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/rcm.2335","article-title":"Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography\/mass spectrometry","volume":"20","author":"Hasegawa","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1749-6632.2009.05145.x","article-title":"Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies","volume":"1187","author":"Herin","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2222.1999.0290s3133.x","article-title":"Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects","volume":"3","author":"Hindmarch","year":"1999","journal-title":"Clin. Exp. Allergy."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0060","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1124\/jpet.108.145813","article-title":"Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors","volume":"329","author":"Hiranita","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(24)29344-7","article-title":"The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates","volume":"298","author":"Howell","year":"2001","journal-title":"J Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1523\/JNEUROSCI.13-01-00266.1993","article-title":"Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals","volume":"13","author":"Kalivas","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3565(24)37956-X","article-title":"Novel 3-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine","volume":"288","author":"Katz","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0070","doi-asserted-by":"crossref","first-page":"S622","DOI":"10.1067\/mai.2000.106153","article-title":"The effects of antihistamines on cognition and performance","volume":"105","author":"Kay","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3940(02)00050-2","article-title":"Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro","volume":"320","author":"Korotkova","year":"2002","journal-title":"Neuroscience letters."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0075","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1016\/j.bmcl.2005.08.028","article-title":"The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines","volume":"15","author":"Lapa","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0080","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ejphar.2004.11.017","article-title":"Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties","volume":"506","author":"Lapa","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-2999(98)00253-2","article-title":"Inhibition of neuronal dopamine uptake by some antiallergic drugs","volume":"350","author":"Matsunaga","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.drugalcdep.2008.10.016","article-title":"Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial","volume":"101","author":"Mooney","year":"2009","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0006-8993(86)90598-6","article-title":"Dopaminergic substrates of cocaine-induced place conditioning","volume":"399","author":"Morency","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0022-3565(24)36440-7","article-title":"The reinforcing and discriminative stimulus effects of the novel cocaine analog 2-propanoyl-3-(4-tolyl)-tropane in rhesus monkeys","volume":"280","author":"Nader","year":"1997","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/0929867305666220314215936","article-title":"Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter","volume":"5","author":"Newman","year":"1998","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0105","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1476-5381.1991.tb12418.x","article-title":"Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene","volume":"104","author":"Nicholson","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00735892","article-title":"Cocaine-induced place conditioning: importance of route of administration and other procedural variables","volume":"94","author":"Nomikos","year":"1988","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-510X(00)00441-X","article-title":"Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients","volume":"182","author":"Ohno","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0120","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neulet.2009.10.025","article-title":"Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice","volume":"467","author":"Oleson","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00213-002-1137-8","article-title":"Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development","volume":"163","author":"Platt","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/030006057700500106","article-title":"Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis","volume":"5","author":"Puhakka","year":"1977","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0135","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0014-2999(79)90250-4","article-title":"In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs","volume":"60","author":"Quach","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0210","doi-asserted-by":"crossref","first-page":"PL17","DOI":"10.1016\/0024-3205(90)90466-5","article-title":"High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development","volume":"46","author":"Rothman","year":"1990","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bcp.2007.08.007","article-title":"Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction","volume":"75","author":"Rothman","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(03)00301-X","article-title":"Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of unrestrained rats","volume":"343","author":"Sabeti","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0150","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/09595230801927372","article-title":"The principles of agonist pharmacotherapy for psychostimulant dependence","volume":"27","author":"Shearer","year":"2008","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0155","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1056\/NEJMra033121","article-title":"Advances in H1-antihistamines","volume":"351","author":"Simons","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2165\/00003495-199957010-00004","article-title":"Second-generation antihistamines: a comparative review","volume":"57","author":"Slater","year":"1999","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0165","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1254\/jjp.81.332","article-title":"Evaluation of the histamine H1-antagonist-induced place preference in rats","volume":"81","author":"Suzuki","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0170","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1471-4159.2008.05361.x","article-title":"Cocaine-like neurochemical effects of antihistaminic medications","volume":"106","author":"Tanda","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2012.03.003_bb1035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1054-3589(08)57007-4","article-title":"Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors","volume":"57","author":"Tanda","year":"2009","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0024-3205(84)90585-X","article-title":"Tripelennamine: enhancement of brain-stimulation reward","volume":"34","author":"Unterwald","year":"1984","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0180","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.pbb.2008.09.013","article-title":"Super-additive interaction of the reinforcing effects of cocaine and H1-antihistamines in rhesus monkeys","volume":"91","author":"Wang","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0185","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0014-2999(81)90280-6","article-title":"Effects of chlorpheniramine, pyrilamine and astemizole on intracranial self-stimulation in rats","volume":"72","author":"Wauquier","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0190","doi-asserted-by":"crossref","first-page":"D901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: a knowledgebase for drugs, drug actions and drug targets","volume":"36","author":"Wishart","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2012.03.003_bb0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0270(01)00459-9","article-title":"Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry","volume":"112","author":"Wu","year":"2001","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0200","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2011.03.017","article-title":"Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection","volume":"182","author":"Yorgason","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2012.03.003_bb0205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0306-4522(99)00309-7","article-title":"Differential sensitivity of the caudal and rostral nucleus accumbens to the rewarding effects of a H1-histaminergic receptor blocker as measured with place-preference and self-stimulation behavior","volume":"94","author":"Zimmermann","year":"1999","journal-title":"Neuroscience"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299912002439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299912002439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:16:19Z","timestamp":1742728579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299912002439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":49,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0014299912002439"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2012.03.003","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}