{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:22:38Z","timestamp":1761016958142},"reference-count":30,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.ejphar.2012.04.029","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T23:01:17Z","timestamp":1335222077000},"page":"15-23","source":"Crossref","is-referenced-by-count":10,"title":["Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation"],"prefix":"10.1016","volume":"685","author":[{"given":"Xiaona","family":"Sheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Nakada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Kashihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Shibazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Horiuchi-Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simmon","family":"Gomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2012.04.029_bb0005","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1073\/pnas.0710501105","article-title":"The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels","volume":"105","author":"Barrett","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0010","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1073\/pnas.81.20.6388","article-title":"Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state","volume":"81","author":"Bean","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0015","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/sj.bjp.0704181","article-title":"Voltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)- and (\u2212)-isradipine","volume":"133","author":"Berjukow","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0020","doi-asserted-by":"crossref","first-page":"22114","DOI":"10.1074\/jbc.M908836199","article-title":"Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation","volume":"275","author":"Berjukow","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1085\/jgp.200910209","article-title":"Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain","volume":"134","author":"Brunet","year":"2009","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0030","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0035","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1085\/jgp.98.2.265","article-title":"Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes","volume":"98","author":"Hadley","year":"1991","journal-title":"J. Gen. Physiol."},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2012.04.029_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1469-7793.1999.00031.x","article-title":"Dihydropyridine enantiomers block recombinant L-type Ca2+ channels by two different mechanisms","volume":"521","author":"Handrock","year":"1999","journal-title":"J. Physiol."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2012.04.029_bb0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1469-7793.2000.t01-1-00237.x","article-title":"Molecular determinants of inactivation in voltage-gated Ca2+ channels","volume":"528","author":"Hering","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0050","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1073\/pnas.94.4.1512","article-title":"Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel alpha1A subunit","volume":"94","author":"Herlitze","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0055","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/311538a0","article-title":"Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists","volume":"311","author":"Hess","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2012.04.029_bb0060","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.37.1.361","article-title":"Molecular determinants of drug binding and action on L-type calcium channels","volume":"37","author":"Hockerman","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0065","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.1093\/nar\/17.13.5404","article-title":"Rapid insertional mutagenesis of DNA by polymerase chain reaction (PCR)","volume":"17","author":"Kammann","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0070","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1529\/biophysj.104.041152","article-title":"Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation","volume":"87","author":"Kobrinsky","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0075","first-page":"50","article-title":"State- and isoform-dependent interaction of isradipine with the alpha1C L-type calcium channel","volume":"440","author":"Lacinova","year":"2000","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0080","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/302790a0","article-title":"Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells","volume":"302","author":"Lee","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2012.04.029_bb0085","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1124\/mol.105.020644","article-title":"Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore","volume":"70","author":"Peterson","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0090","doi-asserted-by":"crossref","first-page":"39424","DOI":"10.1074\/jbc.M607405200","article-title":"The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels","volume":"281","author":"Raybaud","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0095","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1161\/01.RES.55.3.336","article-title":"Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists","volume":"55","author":"Sanguinetti","year":"1984","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0100","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1074\/jbc.M110524200","article-title":"Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel","volume":"277","author":"Shi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0105","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1085\/jgp.99.6.863","article-title":"Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes","volume":"99","author":"Shirokov","year":"1992","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0165-6147(03)00065-8","article-title":"Ca2+ channel moving tail: link between Ca2+\u2010induced inactivation and Ca2+ signal transduction","volume":"24","author":"Soldatov","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cell.2004.09.011","article-title":"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism","volume":"119","author":"Splawski","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2012.04.029_bb0115","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1073\/pnas.0502506102","article-title":"Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations","volume":"102","author":"Splawski","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0135","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0166-2236(00)01738-0","article-title":"Structural determinants of fast inactivation of high voltage-activated Ca(2+) channels","volume":"24","author":"Stotz","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0125","doi-asserted-by":"crossref","first-page":"24575","DOI":"10.1074\/jbc.M000399200","article-title":"Fast inactivation of voltage-dependent calcium channels. A hinged-lid mechanism?","volume":"275","author":"Stotz","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2003.047068","article-title":"Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels","volume":"554","author":"Stotz","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00232-008-9113-9","article-title":"Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes","volume":"222","author":"Yamada","year":"2008","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0145","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1113\/jphysiol.2008.161737","article-title":"The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation","volume":"587","author":"Yarotskyy","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2012.04.029_bb0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/20200","article-title":"Calmodulin supports both inactivation and facilitation of L-type calcium channels","volume":"399","author":"Zuhlke","year":"1999","journal-title":"Nature"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299912003639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299912003639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T22:51:46Z","timestamp":1543013506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299912003639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":30,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0014299912003639"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2012.04.029","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}