{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:24:09Z","timestamp":1790015049235,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ejphar.2012.09.052","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T23:03:56Z","timestamp":1349996636000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats"],"prefix":"10.1016","volume":"697","author":[{"given":"Dezheng","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laifu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2012.09.052_bib1","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1523\/JNEUROSCI.12-06-02362.1992","article-title":"Interaction of the putative essential nutrient pyrroloquline quinone with the N-methyl-d-aspartate receptor redox modulatory site","volume":"12","author":"Aizenman","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2012.09.052_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0304-3940(94)90447-2","article-title":"Further evidence that pyrroloquinoline quinone interacts with the N-methyl-d-aspartate receptor redox site in rat cortical neurons in vitro","volume":"168","author":"Aizenman","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.09.052_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0304-3959(90)90022-6","article-title":"Further evidence for \u2018pain-relaed\u2019 behaviors in a model of unilateral peripheral mononeuropathy","volume":"41","author":"Attal","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/exnr.1998.6875","article-title":"Nk1, NMDA, 5HT1a and 5HT2 receptor binding sites in the rat lumbar spinal cord: modulation following sciatic nerve crush","volume":"154","author":"Croul","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2012.09.052_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(00)00331-6","article-title":"Possible role of inflammatory mediators in tactile hypersensitivity in rat model of mononeuropathy","volume":"88","author":"Cui","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2911(08)60129-0","article-title":"The biochemistry, physiology and genetics of PQQ and PQQ-containing enzymes","volume":"40","author":"Goodwin","year":"1998","journal-title":"Adv. Microbiol. Physiol."},{"key":"10.1016\/j.ejphar.2012.09.052_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0306-4522(95)00196-P","article-title":"Magnesium ions reduce motoneuron death following nerve injury or exposure of N-methyl-d-aspartate in the developing rat","volume":"68","author":"Greensmith","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2012.09.052_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11064-006-9058-2","article-title":"Neuropathic pain modifies antioxidant activity in rat spinal cord","volume":"31","author":"Guedes","year":"2006","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2012.09.052_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-2952(02)01453-3","article-title":"Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems","volume":"65","author":"He","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.09.052_bib12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbrc.2008.11.045","article-title":"Pyrroloquinoline quinone attenuates iNOS gene expression in the injury spinal cord","volume":"378","author":"Hirakawa","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2012.09.052_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-5728(00)00317-9","article-title":"Role of NMDA receptor signaling in the regulation of inflammatory gene expression after focal brain ischemia","volume":"109","author":"Jander","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejphar.2012.09.052_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2012.09.052_bib15","first-page":"1206","article-title":"Nociceptive and inflammatory effects of subcutaneous TNF alpha","volume":"25","author":"Junqer","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pain.2004.06.008","article-title":"Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain","volume":"111","author":"Kim","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3959(01)00392-X","article-title":"Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental monoeuropathy","volume":"95","author":"Kondo","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib18","first-page":"47","article-title":"Partial sciatic nerve transaction","volume":"vol. 99","author":"Lindenlaub","year":"2004"},{"key":"10.1016\/j.ejphar.2012.09.052_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/micr.20126","article-title":"Enhanced rat sciatic nerve regeneration through silicon tubes filled with pyrroloquinoline quinone","volume":"25","author":"Liu","year":"2005","journal-title":"Microsurg"},{"issue":"1-2","key":"10.1016\/j.ejphar.2012.09.052_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0006-8993(92)90193-D","article-title":"Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of the thermal hyperalgesia in rats with painful peripheral","volume":"598","author":"Mao","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2012.09.052_bib21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejpain.2005.08.006","article-title":"Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-l-cysteine in rats","volume":"10","author":"Naik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0024-3205(89)90044-1","article-title":"Preventive effects of pyrroloquinoline quinone on formation of cataract and decline of lenticular and hepatic glutathione of developing chick embryo after glucocorticoid treatment","volume":"45","author":"Nishigori","year":"1989","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2012.09.052_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2005.08.055","article-title":"Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons","volume":"391","author":"Park","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.09.052_bib24","first-page":"268","article-title":"Potential physiological importance of pyrroloquinoline quinone","volume":"14","author":"Rucker","year":"2009","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.ejphar.2012.09.052_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3181\/00379727-197-43219","article-title":"Intestinal absorption and tissue distribution of [14C] pyrroloquionline quinone in mice","volume":"197","author":"Smidt","year":"1991","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2012.09.052_bib26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0006-8993(97)01327-9","article-title":"Painful mononeuropathy in C57BL\/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity","volume":"784","author":"Sommer","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2012.09.052_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3959(97)00154-1","article-title":"The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve","volume":"74","author":"Sommer","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/exnr.1998.6797","article-title":"Hyperalgesia in experimental neuropathy id dependent on the TNF receptor 1","volume":"151","author":"Sommer","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2012.09.052_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(01)02743-3","article-title":"Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy","volume":"91","author":"Sommer","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2012.09.052_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1529-8027.2001.01010.x","article-title":"Etanercept reduces hyperalgesia in experimental painful neuropathy","volume":"6","author":"Sommer","year":"2001","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.ejphar.2012.09.052_bib31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1529-8027.2000.00012.x","article-title":"Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat","volume":"5","author":"Sorkin","year":"2000","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.ejphar.2012.09.052_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3940(00)01091-0","article-title":"Increased immunoreactive labeling of the spinal N-methyl-d-aspartate R1 receptor after dorsal root ganglionectomy in the rats","volume":"286","author":"Tseng","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.09.052_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pain.2004.04.008","article-title":"Peri-sciatic pro-inflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats","volume":"110","author":"Twining","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neulet.2008.03.037","article-title":"Early cytokine gene expression in mouse CNS after peripheral nerve lesion","volume":"436","author":"Uceyler","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.09.052_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1365-2990.2000.00244.x","article-title":"Changes in expression of NMDA receptor subunits in the rat lumbar spinal cord following neonatal nerve injury","volume":"26","author":"Virgo","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ejphar.2012.09.052_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0304-3959(97)00148-6","article-title":"Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneural TNF \u03b1 expression","volume":"74","author":"Wagner","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib37","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1093\/clinchem\/39.12.2522","article-title":"Optimized step in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage","volume":"39","author":"Wasowicz","year":"1993","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ejphar.2012.09.052_bib38","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2012.09.052_bib39","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: etiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2012.09.052_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3959(92)90198-K","article-title":"Spinal pharmacology of the thermal hyperalgesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists","volume":"49","author":"Yamamoto","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2012.09.052_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neures.2006.04.015","article-title":"Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain","volume":"56","author":"Yoshimura","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2012.09.052_bib42","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1046\/j.1460-9568.2002.02169.x","article-title":"The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation","volume":"16","author":"Zhang","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2012.09.052_bib43","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.brainres.2006.03.111","article-title":"Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat","volume":"1094","author":"Zhang","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2012.09.052_bib44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/1074248406288757","article-title":"Comparison of pyrroloquinoline quinine and\/or metoprolol on myocardial infarct size and mitochondrial damage in rat model of ischemia\/reperfusion injury","volume":"11","author":"Zhu","year":"2006","journal-title":"J. Cardiovasc. Pharmacol. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991200845X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991200845X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:16:56Z","timestamp":1757974616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991200845X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":44,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S001429991200845X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2012.09.052","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2012.09.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}