{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:53:35Z","timestamp":1771473215539,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ejphar.2012.11.003","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T01:02:50Z","timestamp":1353459770000},"page":"286-291","source":"Crossref","is-referenced-by-count":59,"title":["Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test"],"prefix":"10.1016","volume":"698","author":[{"given":"Carlos B.","family":"Filho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian Del","family":"Fabbro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo G.","family":"de Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 T.R.","family":"Goes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro C.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana P.","family":"Boeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano R.","family":"Jesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2012.11.003_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","article-title":"Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apopotosis and inflammation","volume":"205","author":"Ahmad","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2012.11.003_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1208\/s12248-009-9105-4","article-title":"Peptide \u03ba-opioid receptor ligands: potential fordrug development","volume":"11","author":"Aldrich","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.ejphar.2012.11.003_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2004.03.041","article-title":"Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice","volume":"363","author":"Berrocoso","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.11.003_bib4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1017\/S1461145709000236","article-title":"Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice modelo f depression","volume":"128","author":"Berrocoso","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib5","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.2174\/138161209788168100","article-title":"Opiates as antidepressants","volume":"15","author":"Berrocoso","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2012.11.003_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00176837","article-title":"Is the forced swimming test a suitable model for revealing antidepressant activity?","volume":"94","author":"Borsini","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2012.11.003_bib8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbr.2009.01.004","article-title":"Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test","volume":"200","author":"Brocardo","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2012.11.003_bib9","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/npp.2009.183","article-title":"Antidepressant-like effects of kappa-opioid receptors antagonists in Wistar Kyoto rats","volume":"35","author":"Carr","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2012.11.003_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2011.06.014","article-title":"Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats","volume":"62","author":"Chartoff","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2012.11.003_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","article-title":"Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication","volume":"50","author":"Chen","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2012.11.003_bib12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/BF02968255","article-title":"Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin","volume":"29","author":"Cho","year":"2006","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejphar.2012.11.003_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0197-0186(00)00034-6","article-title":"Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors","volume":"38","author":"Cunha","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2012.11.003_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2005.02.039","article-title":"Synergistic interaction between hesperidin, a natural flavonoid, and diazepam","volume":"512","author":"Fern\u00e1ndez","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1074","article-title":"Chemistry and pharmacology of the Citrus bioflavonoid hesperidin","volume":"15","author":"Garg","year":"2001","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejphar.2012.11.003_bib16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1124\/jpet.111.185108","article-title":"Pharmacological characterization of 2-methyl-N-((2\u2019-pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for \u03ba-opioid receptor","volume":"339","author":"Grimwood","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2012.11.003_bib17","series-title":"Opioid analgesics, in Goodman & Gilman\u2019s: The Pharmacological Basis of Therapeutics","author":"Gutstein","year":"2006"},{"key":"10.1016\/j.ejphar.2012.11.003_bib18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1021\/jf072826r","article-title":"Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells","volume":"56","author":"Hwang","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2012.11.003_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2003.10.040","article-title":"Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors","volume":"355","author":"Kaster","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2012.11.003_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainresbull.2005.05.025","article-title":"Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test","volume":"67","author":"Kaster","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2012.11.003_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2007.08.026","article-title":"Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of adenosine in the mouse forced swimming test","volume":"576","author":"Kaster","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib22","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/sj.bjp.0705179","article-title":"Effects of U-50488H and U-50488H withdrawal on c-fos expression in the rat paraventricular nucleus. Correlation with c-fos in brainstem catecholaminergic neurons","volume":"138","author":"Laorden","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.pharmtox.40.1.389","article-title":"Molecular mechanisms and regulation of opioid receptor signaling","volume":"40","author":"Law","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.toxlet.2010.01.021","article-title":"The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kB in human hepatocellular carcinoma cells","volume":"194","author":"Lee","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2012.11.003_bib25","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.pnpbp.2008.01.012","article-title":"Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test","volume":"32","author":"Lobato","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2012.11.003_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2007.11.011","article-title":"Opoid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines","volume":"580","author":"Loscalzo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pbb.2011.05.018","article-title":"Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to \u03bc-opioid receptor and inhibits GIRK1\/2 currents","volume":"99","author":"Loscalzo","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2012.11.003_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0165-0327(99)00121-4","article-title":"Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness","volume":"58","author":"Maes","year":"2000","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2012.11.003_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1124\/jpet.102.046433","article-title":"Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats","volume":"305","author":"Mague","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2012.11.003_bib30","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/sj.bjp.0703432","article-title":"Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test","volume":"30","author":"Makino","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib32","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1523\/JNEUROSCI.23-13-05674.2003","article-title":"Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses","volume":"23","author":"McLaughlin","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2012.11.003_bib33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0165-0173(00)00033-3","article-title":"Adenosine: does it have a neuroprotective role after all?","volume":"33","author":"Mendon\u00e7a","year":"2000","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejphar.2012.11.003_bib34","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","article-title":"Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments","volume":"15","author":"Nibuya","year":"1995","journal-title":"J. Neurosci."},{"issue":"Suppl E1","key":"10.1016\/j.ejphar.2012.11.003_bib35","first-page":"4","article-title":"Relationship of neurotransmitters to the symptoms of major depressive disorder","volume":"69","author":"Nutt","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2012.11.003_bib36","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/j.1476-5381.2012.02078.x","article-title":"Kappa-opioid receptor agonist activity of the atypical antidepressant mianserin","volume":"167","author":"Olianas","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib37","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2012.11.003_bib38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2174\/187152710791012116","article-title":"Targenting opioid receptors: a new treatment for brain disorders","volume":"9","author":"Rahman","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ejphar.2012.11.003_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0301-0082(02)00155-7","article-title":"Adenosine receptors in the nervous system: pathophysiological implications","volume":"68","author":"Ribeiro","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib40","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0024-3205(01)01498-9","article-title":"Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus","volume":"70","author":"Rodrigues","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2012.11.003_bib41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1476-5381.2011.01544.x","article-title":"Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting \u03ba opioid receptor antagonism","volume":"165","author":"Ross","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.11.003_bib42","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/sj.npp.1300514","article-title":"Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise","volume":"29","author":"Russo-Neustadt","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2012.11.003_bib43","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pbb.2010.07.009","article-title":"Contributions of peripheral and central opioid receptors to antinociception in rat muscle pain models","volume":"96","author":"S\u00e1nchez","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2012.11.003_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/hup.829","article-title":"Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative\u2013antioxidative systems","volume":"22","author":"Sarandol","year":"2007","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.ejphar.2012.11.003_bib45","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1471-4159.2004.02589.x","article-title":"Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects","volume":"90","author":"Shirayama","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2012.11.003_bib46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jad.2005.12.010","article-title":"Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants","volume":"91","author":"Tsuboi","year":"2006","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2012.11.003_bib47","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/aps.2010.138","article-title":"The role of \u03ba-opioid receptor activation in mediating antinociception and addiction","volume":"31","author":"Wang","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2012.11.003_bib48","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/jf2040675","article-title":"Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from Hesperitin-administered rat serum: na ex vivo approach","volume":"60","author":"Yang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2012.11.003_bib49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2007.05.045","article-title":"Central kappa \u2013 opioid receptor-mediated antidepressant-like effects of nor-binaltorphimine: behavioral and BDNF mRNA expression studies","volume":"570","author":"Zhang","year":"2007","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991200934X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429991200934X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T21:00:55Z","timestamp":1562360455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429991200934X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":47,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S001429991200934X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2012.11.003","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}