{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:38:22Z","timestamp":1780630702889,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Deutsche Krebshilfe and the F\u00f6rderclub Mastzellforschung e.V"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ejphar.2012.12.003","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T10:31:48Z","timestamp":1356172308000},"page":"152-158","source":"Crossref","is-referenced-by-count":16,"title":["Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells"],"prefix":"10.1016","volume":"700","author":[{"given":"Kristina","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Altarcheh","family":"Xifr\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Lisa","family":"Hartweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Spitzlei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard J.","family":"Molderings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar von","family":"K\u00fcgelgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejphar.2012.12.003_bib1","first-page":"40","article-title":"Evidence for the involvement of peripheral-type benzodiazepine receptors in the inhibitory effects of diazepam, flunitrazepam and 4\u2032-chlorodiazepam on the interleukin-8 production in human mast cells","volume":"381","author":"Altarcheh Xifr\u00f3","year":"2010","journal-title":"Naunyn-Schmiedeberg\u00b4s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1398-9995.2012.02812.x","article-title":"Increased serum baseline tryptase levels and extensive skin involvement are predictors for the severity of mast cell activation episodes in children with mastocytosis","volume":"67","author":"Alvarez-Twose","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2012.12.003_bib3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/cvr\/cvp241","article-title":"Interleukin-8 and cardiovascular disease","volume":"84","author":"Apostolakis","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2012.12.003_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/A:1006456715525","article-title":"The peripheral benzodiazepine receptors: a review","volume":"46","author":"Beurdeley-Thomas","year":"2000","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0162-3109(99)00046-6","article-title":"Inhibition of mouse mast cell proliferation and proinflammatory mediator release by benzodiazepines","volume":"43","author":"Bidri","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ejphar.2012.12.003_bib6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.bcp.2008.07.011","article-title":"A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation","volume":"76","author":"Buceta","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1124\/mol.105.015289","article-title":"Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells","volume":"69","author":"Costa","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib8","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/sj.bjp.0706251","article-title":"Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABAA receptors supports an allosteric model of modulation","volume":"145","author":"Downing","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib9","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI118245","article-title":"Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma","volume":"96","author":"Feoktistov","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2012.12.003_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/B978-0-12-385526-8.00005-9","article-title":"Role of adenosine A2B receptors in inflammation","volume":"61","author":"Feoktistov","year":"2011","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0026-895X(24)23035-2","article-title":"Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells","volume":"55","author":"Feoktistov","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.RES.0000061572.10929.2D","article-title":"Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors","volume":"92","author":"Feoktistov","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2012.12.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.110.003285","article-title":"International union of basic and clinical pharmacology. LXXXI. Nomenclature and classification of adenosine receptors\u2014an update","volume":"63","author":"Fredholm","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2012.12.003_bib14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/clpt.1992.123","article-title":"Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time","volume":"52","author":"Friedman","year":"1992","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2012.12.003_bib15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1213\/01.ane.0000166955.97368.80","article-title":"Inhibitory effects of intravenous anesthetics on mast cell function","volume":"101","author":"Fujimoto","year":"2005","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2012.12.003_bib16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0031-6997(24)01424-8","article-title":"Enigma of the peripheral benzodiazepine receptor","volume":"51","author":"Gavish","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2012.12.003_bib17","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.bcp.2008.08.029","article-title":"Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y12-receptor","volume":"76","author":"Hoffmann","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.coi.2009.09.007","article-title":"New roles for mast cells in modulating allergic reactions and immunity against pathogens","volume":"21","author":"Hofmann","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s00063-010-1093-8","article-title":"Die systemische Mastozytose\u2014Standortbestimmung einer internistischen Erkrankung. Systemic mastocytosis-definition of an internal disease","volume":"105","author":"Homann","year":"2010","journal-title":"Med. Klin."},{"key":"10.1016\/j.ejphar.2012.12.003_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrd1983","article-title":"Adenosine receptors as therapeutic targets","volume":"5","author":"Jacobson","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.ejphar.2012.12.003_bib21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0006-2952(01)00531-7","article-title":"[3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors","volume":"61","author":"Ji","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.imlet.2007.08.007","article-title":"G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation","volume":"113","author":"Kuehn","year":"2007","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ejphar.2012.12.003_bib23","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/sj.onc.1204386","article-title":"Partners in transcription: NFAT and AP-1","volume":"20","author":"Maci\u00e1n","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2012.12.003_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/cvr\/cvq371","article-title":"A2B receptors mediate the induction of early genes and inhibition of arterial smooth muscle cell proliferation via Epac","volume":"90","author":"Mayer","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2012.12.003_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0006-2952(02)01058-4","article-title":"Induction of interleukin 8 release from the HMC-1 mast cell line: synergy between stem cell factor and activators of the adenosine A2b receptor","volume":"64","author":"Meade","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2012.12.003_bib26","first-page":"43","article-title":"Investigation on the molecular mechanisms mediating the inhibitory effect of benzodiazepines on mast cells","volume":"379","author":"Meis","year":"2009","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000138346","article-title":"High-affinity benzodiazepine binding sites on rat peritoneal mast cells and RBL-1 cells: binding characteristics and effects on granule secretion","volume":"36","author":"Miller","year":"1988","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejphar.2012.12.003_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1756-8722-4-10","article-title":"Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options","volume":"22","author":"Molderings","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib29","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/00365520701245744","article-title":"Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder","volume":"42","author":"Molderings","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(24)01439-X","article-title":"International union of pharmacology. XXII. Nomenclature for chemokine receptors","volume":"52","author":"Murphy","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2012.12.003_bib31","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.4049\/jimmunol.180.11.7212","article-title":"Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells","volume":"180","author":"Ryzhov","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2217\/fon.09.128","article-title":"CXCL8 and its cognate receptors in melanoma progression and metastasis","volume":"6","author":"Singh","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0014-2999(89)90749-8","article-title":"Effects of benzodiazepines on serotonin release from rat mast cells","volume":"167","author":"Suzuki-Nishimura","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2012.12.003_bib34","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/MOP.0b013e328355b248","article-title":"Childhood mastocytosis","volume":"24","author":"Torrelo","year":"2012","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.ejphar.2012.12.003_bib35","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2012.12.003_bib36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.intimp.2009.11.009","article-title":"Suppressive effect of diazepam on IFN-gamma production by human T cells","volume":"10","author":"Wei","year":"2010","journal-title":"Int. Immunopharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299912010084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299912010084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T14:58:46Z","timestamp":1745938726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299912010084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":36,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0014299912010084"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2012.12.003","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}