{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:31:49Z","timestamp":1789720309049,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ejphar.2013.01.038","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T12:50:18Z","timestamp":1360155018000},"page":"56-61","source":"Crossref","is-referenced-by-count":11,"title":["Bimatoprost protects retinal neuronal damage via Akt pathway"],"prefix":"10.1016","volume":"702","author":[{"given":"Norihito","family":"Takano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tsuruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2013.01.038_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ejphar.2013.01.038_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/1568026053507714","article-title":"The Akt\/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation","volume":"5","author":"Barnett","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2013.01.038_bib3","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.survophthal.2008.08.012","article-title":"Commercially available prostaglandin analogs for the reduction of intraocular pressure: similarities and differences","volume":"53","author":"Bean","year":"2008","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.coph.2012.09.012","article-title":"Pharmacological management of ocular hypertension: current approaches and future prospective","volume":"13","author":"Bucolo","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib5","first-page":"413","article-title":"A historical perspective and recent advances in prostamide research and therapeutics","volume":"10","author":"Burk","year":"2007","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1016\/j.ejphar.2013.01.038_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death\u2014apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2013.01.038_bib7","first-page":"161","article-title":"Overexpression of thioredoxins 1 and 2 increases retinal ganglion cell survival after pharmacologically induced oxidative stress, optic nerve transection, and in experimental glaucoma","volume":"107","author":"Caprioli","year":"2010","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.ejphar.2013.01.038_bib8","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.clinthera.2008.04.006","article-title":"Meta-analysis of 13 randomized controlled trials comparing bimatoprost with latanoprost in patients with elevated intraocular pressure","volume":"30","author":"Cheng","year":"2008","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejphar.2013.01.038_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.mcn.2003.11.001","article-title":"Regulation of caspase activation in axotomized retinal ganglion cells","volume":"25","author":"Cheung","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2013.01.038_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/108076803762718105","article-title":"Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro","volume":"19","author":"Davies","year":"2003","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2013.01.038_bib11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/exer.2000.0975","article-title":"Latanoprost exerts neuroprotective activity in vitro and in vivo","volume":"72","author":"Drago","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2013.01.038_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2165\/00002512-200219030-00008","article-title":"Topical bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension","volume":"19","author":"Easthope","year":"2002","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ejphar.2013.01.038_bib13","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.exer.2008.02.008","article-title":"Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments","volume":"86","author":"Hernandez","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2013.01.038_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/bjo.2007.123737","article-title":"The efficacy and harm of prostaglandin analogues for IOP reduction in glaucoma patients compared to dorzolamide and brimonidine: a systematic review","volume":"92","author":"Hodge","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.exer.2008.11.012","article-title":"Latanoprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo","volume":"88","author":"Kanamori","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2013.01.038_bib16","doi-asserted-by":"crossref","first-page":"43871","DOI":"10.1074\/jbc.M105256200","article-title":"Alternate FGF2-ERK1\/2 signaling pathways in retinal photoreceptor and glial cells in vitro","volume":"276","author":"Kinkl","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.038_bib17","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00417-005-0215-0","article-title":"Neuroprotective effect of latanoprost on rat retinal ganglion cells","volume":"244","author":"Kudo","year":"2006","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ohc.2005.04.002","article-title":"Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies","volume":"18","author":"Kuehn","year":"2005","journal-title":"Ophthalmol. Clin. North Am."},{"key":"10.1016\/j.ejphar.2013.01.038_bib19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/bjp.2008.142","article-title":"Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes","volume":"154","author":"Liang","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib20","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1460-9568.2007.05718.x","article-title":"PI3K\/akt, JAK\/STAT and MEK\/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury","volume":"26","author":"Luo","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2013.01.038_bib21","doi-asserted-by":"crossref","first-page":"C671","DOI":"10.1152\/ajpcell.00549.2009","article-title":"Prostaglandin F2α stimulates PI3K\/ERK\/mTOR signaling and skeletal myotube hypertrophy","volume":"300","author":"Markworth","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0304-3940(02)00427-5","article-title":"Ergothioneine treatment protects neurons against N-methyl-d-aspartate excitotoxicity in an in vivo rat retinal model","volume":"328","author":"Moncaster","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2013.01.038_bib23","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1167\/iovs.08-1716","article-title":"Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress","volume":"49","author":"Munemasa","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2013.01.038_bib24","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.exer.2006.05.018","article-title":"Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44\/p42 mitogen-activated protein kinase","volume":"83","author":"Nakanishi","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2013.01.038_bib25","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1167\/iovs.09-3999","article-title":"ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture","volume":"51","author":"Osborne","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2013.01.038_bib26","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.biocel.2008.04.009","article-title":"The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells","volume":"40","author":"Ramos","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib27","doi-asserted-by":"crossref","first-page":"33630","DOI":"10.1074\/jbc.M105322200","article-title":"Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells","volume":"276","author":"Reusch","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2013.01.038_bib28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1242\/jcs.017194","article-title":"The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation","volume":"121","author":"Rygiel","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2013.01.038_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/108076803322660422","article-title":"Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells","volume":"19","author":"Sharif","year":"2003","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2013.01.038_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00055735-199604000-00003","article-title":"Latanoprost as a new horizon in the medical management of glaucoma","volume":"7","author":"Stjernschantz","year":"1996","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib31","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/jnr.22691","article-title":"Involvement of Bid and caspase-2 in endoplasmic reticulum stress- and oxidative stress-induced retinal ganglion cell death","volume":"89","author":"Uchibayashi","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2013.01.038_bib32","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jclinepi.2008.04.012","article-title":"A network meta-analysis combined direct and indirect comparisons between glaucoma drugs to rank effectiveness in lowering intraocular pressure","volume":"62","author":"van der Valk","year":"2009","journal-title":"J. Clin. Epidemiol."},{"issue":"Suppl. 4","key":"10.1016\/j.ejphar.2013.01.038_bib33","doi-asserted-by":"crossref","first-page":"S337","DOI":"10.1016\/S0039-6257(01)00224-7","article-title":"The pharmacology of bimatoprost (Lumigan)","volume":"45","author":"Woodward","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.ejphar.2013.01.038_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10571-011-9653-x","article-title":"Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway","volume":"31","author":"Zheng","year":"2011","journal-title":"Cell. Mol. Neurobiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913000587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299913000587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T19:32:08Z","timestamp":1539891128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299913000587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":34,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0014299913000587"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2013.01.038","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}